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  • Ferraro, Gino B.Massachusetts General Hospital (author)

Fatty acid synthesis is required for breast cancer brain metastasis

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-04-01
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:f3d62067-1c77-400c-a257-e5b1f521709c
  • https://research.chalmers.se/publication/523324URI
  • https://doi.org/10.1038/s43018-021-00183-yDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Brain metastases are refractory to therapies that control systemic disease in patients with human epidermal growth factor receptor 2-positive breast cancer and the brain microenvironment contributes to this therapy resistance. Nutrient availability can vary across tissues, therefore metabolic adaptations required for brain metastatic breast cancer growth may introduce liabilities that can be exploited for therapy. Here we assessed how metabolism differs between breast tumors in brain versus extracranial sites and found that fatty acid synthesis is elevated in breast tumors growing in the brain. We determine that this phenotype is an adaptation to decreased lipid availability in the brain relative to other tissues, resulting in site-specific dependency on fatty acid synthesis for breast tumors growing at this site. Genetic or pharmacological inhibition of fatty acid synthase reduces human epidermal growth factor receptor 2-positive breast tumor growth in the brain, demonstrating that differences in nutrient availability across metastatic sites can result in targetable metabolic dependencies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ali, AhmedMassachusetts Institute of Technology (MIT) (author)
  • Luengo, AlbaMassachusetts Institute of Technology (MIT) (author)
  • Kodack, David P.Novartis Institutes for BioMedical Research,Massachusetts General Hospital (author)
  • Deik, AmyMassachusetts Institute of Technology (MIT) (author)
  • Abbott, Keene L.Massachusetts Institute of Technology (MIT) (author)
  • Bezwada, DivyaMassachusetts General Hospital (author)
  • Blanc, LandryRutgers University,Institut de Chimie et de Biologie des Membranes et des Nano-Objets (CBMN) (author)
  • Prideaux, BrendanThe University of Texas at Austin, USA,Rutgers University (author)
  • Jin, XinMassachusetts Institute of Technology (MIT) (author)
  • Possada, Jessica M.Brigham and Women's Hospital,Massachusetts General Hospital (author)
  • Chen, JiangMassachusetts General Hospital (author)
  • Chin, Christopher R.Massachusetts Institute of Technology (MIT) (author)
  • Amoozgar, ZohrehMassachusetts General Hospital (author)
  • Ferreira, Raphael,1990Chalmers tekniska högskola,Chalmers University of Technology,Massachusetts Institute of Technology (MIT)(Swepub:cth)rapfer (author)
  • Chen, Ivy X.Massachusetts General Hospital (author)
  • Naxerova, KamilaHarvard Medical School,Massachusetts General Hospital (author)
  • Ng, ChristopherMassachusetts Institute of Technology (MIT) (author)
  • Westermark, Anna M.Massachusetts Institute of Technology (MIT) (author)
  • Duquette, MarkMassachusetts General Hospital (author)
  • Roberge, SylvieMassachusetts General Hospital (author)
  • Lindeman, Neal I.Brigham and Women's Hospital (author)
  • Lyssiotis, Costas A.University of Michigan,Harvard Medical School (author)
  • Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
  • Housman, David E.Massachusetts Institute of Technology (MIT) (author)
  • Duda, Dan G.Massachusetts General Hospital (author)
  • Brachtel, ElenaHarvard Medical School (author)
  • Golub, Todd R.Massachusetts Institute of Technology (MIT) (author)
  • Cantley, Lewis C.Harvard Medical School (author)
  • Asara, John M.Harvard Medical School (author)
  • Davidson, Shawn M.Massachusetts Institute of Technology (MIT),Princeton University (author)
  • Fukumura, DaiMassachusetts General Hospital (author)
  • Dartois, Véronique A.Rutgers University,Hackensack Meridian Health (author)
  • Clish, Clary B.Massachusetts Institute of Technology (MIT) (author)
  • Jain, Rakesh K.Massachusetts General Hospital (author)
  • Vander Heiden, Matthew G.Massachusetts Institute of Technology (MIT),Dana-Farber Cancer Institute (author)
  • Massachusetts General HospitalMassachusetts Institute of Technology (MIT) (creator_code:org_t)

Related titles

  • In:Nature Cancer: Springer Science and Business Media LLC2:4, s. 414-4282662-1347

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