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Neuroprotective eff...
Neuroprotective effects of N-acetylcysteine amide on experimental focal penetrating brain injury in rats
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- Gunther, M. (author)
- Karolinska Institutet
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- Davidsson, Johan, 1967 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Plantman, S (author)
- Karolinska Institutet
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- Norgren, S. (author)
- Karolinska Institutet
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- Mathiesen, T. (author)
- Karolinska Institutet
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- Risling, M (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Journal of Clinical Neuroscience. - : Elsevier BV. - 0967-5868 .- 1532-2653. ; 22:9, s. 1477-1483
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http://dx.doi.org/10...
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Abstract
Subject headings
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- We examined the effects of N-acetylcysteine amide (NACA) in the secondary inflammatory response following a novel method of focal penetrating traumatic brain injury (TBI) in rats. N-acetylcysteine (NAC) has limited but well-documented neuroprotective effects after experimental central nervous system ischemia and TBI, but its bioavailability is very low. We tested NACA, a modified form of NAC with higher membrane and blood-brain barrier permeability. Focal penetrating TBI was produced in male Sprague-Dawley rats randomly selected for NACA treatment (n = 5) and no treatment (n = 5). In addition, four animals were submitted to sham surgery. After 2 hours or 24 hours the brains were removed, fresh frozen, cut in 14 mu m coronal sections and subjected to immunohistochemistry, immunofluorescence, Fluoro-Jade and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analyses. All treated animals were given 300 mg/kg NACA intraperitoneally (IP) 2 minutes post trauma. The 24 hour survival group was given an additional bolus of 300 mg/kg IF after 4 hours. NACA treatment decreased neuronal degeneration by Fluoro-Jade at 24 hours with a mean change of 35.0% (p
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Neurosciences & Neurology
- oxidative stress
- thiol antioxidant
- protects
- contusion
- bioenergetics
- activation
- N-acetylcysteine amide
- Neuroprotection
- glutathione
- Traumatic brain injury
- traumatic brain
- superoxide
- Inflammation
- Sprague-Dawley
- neurodegeneration
Publication and Content Type
- art (subject category)
- ref (subject category)
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