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Cervical excisional...
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Wiik, J.Göteborgs universitet,University of Gothenburg
(author)
Cervical excisional treatment, HPV infection and risk of preterm delivery - a Swedish population-based study
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-10-07
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© 2020. Thieme. All rights reserved.2020
Numbers
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LIBRIS-ID:oai:research.chalmers.se:f4980378-c2aa-4a64-a8e1-96f01488c971
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https://research.chalmers.se/publication/519971URI
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https://doi.org/10.1055/s-0040-1717180DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Objective Excisional treatment for cervical intraepithelial neoplasia (CIN) is associated with preterm delivery (PTD). It has been shown that even untreated CIN is associated with PTD. We aimed to explore the magnitude of the associations of CIN with PTD and adverse obstetrical outcome. Methods Retrospective register-based study comprising all women with singleton deliveries in Sweden 1999-2016. Data were retrieved from the Medical Birth Registry and the Swedish National Cervical Screening Registry. Women with normal cytology all life (n = 340,290) were compared to a) women with sign of HPV-infection close to pregnancy (abnormal cytology (n = 11,936) or positive HPV-test (n = 2,587)), b) women treated for CIN before delivery (n = 25,123) and c) women with CIN/carcinoma diagnosed after delivery (n = 34,251) by logistic regression adjusted for socioeconomic and health-related confounders. Results PTD was increased in all groups compared to women with normal cytology all life (4.7 %), with greatest risk for the treated group (9,0 %, OR 1.80 (1.71-1.89)), but also for women with HPV-infection close to pregnancy (5,9 %, OR 1.19 (1.10-1.29)) and CIN/carcinoma after delivery (6,1 %, OR 1.10 (1.04-1.16)). Paired analysis in 5,547 women with deliveries both before and after treatment showed increased risk of PTD after treatment (OR 1.27 (1.07-1.50)). The treated group had increased risk also for preterm prelabour rupture of the membranes (pPROM, OR 2.25 (2.08-2.44)) and chorioamnionitis (2.44 (2.05-2.90)). HPV-infection close to pregnancy was associated with pPROM (OR 1.22 (1.06-1.40)). Conclusions Women with HPV infection close to pregnancy have a small increased risk for PTD and pPROM while excisional treatment increases risks further.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Nilsson, Staffan,1956Chalmers tekniska högskola,Chalmers University of Technology,Göteborgs universitet,University of Gothenburg(Swepub:cth)staffan
(author)
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Kaerrberg, C.Göteborgs universitet,University of Gothenburg
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Strander, B.Göteborgs universitet,University of Gothenburg
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Jacobsson, B.Göteborgs universitet,University of Gothenburg
(author)
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Sengpiel, VGöteborgs universitet,University of Gothenburg
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Göteborgs universitetChalmers tekniska högskola
(creator_code:org_t)
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In:Geburtshilfe und Frauenheilkunde: © 2020. Thieme. All rights reserved.80:101438-88040016-5751
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