Chemical release from single PMMA microparticles monitored by CARS microscopy

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Enejder, Annika,1969Chalmers tekniska högskola,Chalmers University of Technology (författare)

Chemical release from single PMMA microparticles monitored by CARS microscopy

Artikel/kapitelEngelska2011

Förlag, utgivningsår, omfång ...

SPIE,2011

Nummerbeteckningar

LIBRIS-ID:oai:research.chalmers.se:f94203ea-5872-43e0-9e06-6e9ce1c3fa93
ISBN:9780819484406
https://doi.org/10.1117/12.874537DOI
https://research.chalmers.se/publication/141367URI

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Språk:engelska
Sammanfattning på:engelska

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Ämneskategori:kon swepub-publicationtype
Ämneskategori:vet swepub-contenttype

Anmärkningar

Microparticles loaded with antigens, proteins, DNA, fungicides, and other functional agents emerge as ideal vehicles for vaccine, drug delivery, genetic therapy, surface- and crop protection. The microscopic size of the particles and their collective large specific surface area enables highly active and localized release of the functional substance. In order to develop designs with release profiles optimized for the specific application, it is desirable to map the distribution of the active substance within the particle and how parameters such as size, material and morphology affect release rates at single particle level. Current imaging techniques are limited in resolution, sensitivity, image acquisition time, or sample treatment, excluding dynamic studies of active agents in microparticles. Here, we demonstrate that the combination of CARS and THG microscopy can successfully be used, by mapping the spatial distribution and release rates of the fungicide and food preservative IPBC from different designs of PMMA microparticles at single-particle level. By fitting a radial diffusion model to the experimental data, single particle diffusion coefficients can be determined. We show that release rates are highly dependent on the size and morphology of the particles. Hence, CARS and THG microscopy provides adequate sensitivity and spatial resolution for quantitative studies on how single-particle properties affect the diffusion of active agents at microscopic level. This will aid the design of innovative microencapsulating systems for controlled release.

Ämnesord och genrebeteckningar

NATURVETENSKAP Kemi hsv//swe
NATURAL SCIENCES Chemical Sciences hsv//eng
Controlled release
Microparticles
Iodine carbamate
Diffusion coefficient
Non-linear microscopy
Coherent anti-stokes raman scattering
Third harmonic generation

Biuppslag (personer, institutioner, konferenser, titlar ...)

Svedberg, Fredrik,1973Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)fredriks (författare)
Nordstierna, Lars,1976Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nlars (författare)
Nydén, Magnus,1970Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)mnyden (författare)
Chalmers tekniska högskola (creator_code:org_t)

Sammanhörande titlar

Ingår i:Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Multiphoton Microscopy in the Biomedical Sciences XI; San Francisco, CA; 23-25 January 2011: SPIE79031605-74229780819484406

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Av författaren/redakt...: Enejder, Annika, ...; Svedberg, Fredri ...; Nordstierna, Lar ...; Nydén, Magnus, 1 ...

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NATURVETENSKAP: NATURVETENSKAP; och Kemi

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Av lärosätet: Chalmers tekniska högskola

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