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Influence of Substi...
Influence of Substitution Pattern on Solution Behavior of Hydroxypropyl Methylcellulose
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- Viridén, Anna, 1977 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Wittgren, Bengt (författare)
- AstraZeneca AB
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- Andersson, Thomas (författare)
- AstraZeneca AB
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- Abrahmsén-Alami, Susanna (författare)
- AstraZeneca AB
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- Larsson, Anette, 1966 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- American Chemical Society (ACS), 2009
- 2009
- Engelska.
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Ingår i: Biomacromolecules. - : American Chemical Society (ACS). - 1525-7797 .- 1526-4602. ; 10:3, s. 522-529
- Relaterad länk:
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http://dx.doi.org/10...
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https://research.cha...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Industrially produced hydroxypropyl Me cellulose (HPMC) is a chem. heterogeneous material, and it is thus difficult to predict parameters related to function on the basis of the polymer's av. chem. values. In this study, the soln. behavior of 7 HPMC batches was correlated to the mol. wt., degree of substitution, and substituent pattern. The initial onset of phase sepn., so-called clouding, generally followed an increased av. mol. wt. and degree of substitution. However, the slope of the clouding curve was affected by the substitution pattern, where the heterogeneously substituted batches had very shallow slopes. Further investigations showed that the appearance of a shallow slope of the clouding curve was a result of the formation of reversible polymer structures, formed as a result of the heterogeneous substituent pattern. These structures grew in size with temp. and concn. and resulted in an increase in the viscosity of the solns. at higher temps.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- Viscosity (substitution pattern effect on soln. behavior of hydroxypropyl Me cellulose)
- Phase separation
- substitution soln behavior hydroxypropyl methyl cellulose
- Molecular weight distribution
- Cloud point
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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