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  • Olafsdottir, TorunnGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology (author)

Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-12-13
  • Springer Science and Business Media LLC,2016
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:research.chalmers.se:fdbf8c0c-7362-4976-9861-72108dac640c
  • https://research.chalmers.se/publication/246853URI
  • https://doi.org/10.1038/srep39097DOI
  • https://gup.ub.gu.se/publication/249379URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • A better understanding of the mechanisms of action of human adjuvants could inform a rational development of next generation vaccines for human use. Here, we exploited a genome wide transcriptomics analysis combined with a systems biology approach to determine the molecular signatures induced by four clinically tested vaccine adjuvants, namely CAF01, IC31, GLA-SE and Alum in mice. We report signature molecules, pathways, gene modules and networks, which are shared by or otherwise exclusive to these clinical-grade adjuvants in whole blood and draining lymph nodes of mice. Intriguingly, co-expression analysis revealed blood gene modules highly enriched for molecules with documented roles in T follicular helper (TFH) and germinal center (GC) responses. We could show that all adjuvants enhanced, although with different magnitude and kinetics, TFH and GC B cell responses in draining lymph nodes. These results represent, to our knowledge, the first comparative systems analysis of clinically tested vaccine adjuvants that may provide new insights into the mechanisms of action of human adjuvants.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lindqvist, Madelene,1982Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xlindm (author)
  • Nookaew, Intawat,1977Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)intawat (author)
  • Andersen, P.Statens Serum Institut (author)
  • Maertzdorf, J.Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG) (author)
  • Persson, Josefine,1980Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xpersj (author)
  • Christensen, D.Statens Serum Institut (author)
  • Zhang, YuanGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xzhany (author)
  • Anderson, JennaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xajenl (author)
  • Khoomrung, Sakda,1978Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sakda (author)
  • Sen, Partho,1983Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)sarathi (author)
  • Agger, E. M.Statens Serum Institut (author)
  • Coler, R.Infectious Disease Research Institute (author)
  • Carter, D.Infectious Disease Research Institute (author)
  • Harandi, Ali M,1968Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology(Swepub:gu)xharal (author)
  • Rappuoli, R. (author)
  • Kaufmann, S. H. E.Max Planck Gesellschaft zur Förderung der Wissenschaften e.V. (MPG),Max Planck Society for the Advancement of Science (MPG) (author)
  • Reed, S. G.Infectious Disease Research Institute (author)
  • Harandi, A. M.Göteborgs universitet,University of Gothenburg (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för mikrobiologi och immunologi (creator_code:org_t)

Related titles

  • In:Scientific Reports: Springer Science and Business Media LLC62045-23222045-2322

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