Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism

• Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of alpha-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.

Ämnesord

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Acetyl-CoA

Saccharomyces cerevisiae

saccharomyces-cerevisiae

pyruvate-decarboxylase

expression

Cell factory

growth-rate

precursor

synthetase

alpha-Santalene

sequence

glucose

transcription

fermentation

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)