L773:1096 7176 OR L773:1096 7184
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- Chen, Yun,1978Chalmers tekniska högskola,Chalmers University of Technology (author)
Establishing a platform cell factory through engineering of yeast acetyl-CoA metabolism
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- Elsevier BV,2013
Numbers
- LIBRIS-ID:oai:research.chalmers.se:fec1a53c-5979-4b24-9b64-f30689d46799
- https://doi.org/10.1016/j.ymben.2012.11.002DOI
- https://research.chalmers.se/publication/174007URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Production of fuels and chemicals by industrial biotechnology requires efficient, safe and flexible cell factory platforms that can be used for production of a wide range of compounds. Here we developed a platform yeast cell factory for efficient provision of acetyl-CoA that serves as precursor metabolite for a wide range of industrially interesting products. We demonstrate that the platform cell factory can be used to improve the production of alpha-santalene, a plant sesquiterpene that can be used as a perfume by four-fold. This strain would be a useful tool to produce a wide range of acetyl-CoA-derived products.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- Acetyl-CoA
- Saccharomyces cerevisiae
- saccharomyces-cerevisiae
- pyruvate-decarboxylase
- expression
- Cell factory
- growth-rate
- precursor
- synthetase
- alpha-Santalene
- sequence
- glucose
- transcription
- fermentation
Added entries (persons, corporate bodies, meetings, titles ...)
- Daviet, L. (author)
- Schalk, M. (author)
- Siewers, Verena,1976Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)siewers (author)
- Nielsen, Jens B,1962Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)nielsenj (author)
- Chalmers tekniska högskola (creator_code:org_t)
Related titles
- In:Metabolic Engineering: Elsevier BV15:1, s. 48-541096-71761096-7184
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- Chalmers University of Technology
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