P-glycoprotein in intestines, liver, kidney and lymphocytes in horse

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Tydén Jonas) > (2006-2009) > P-glycoprotein in i...

Tyden, EvaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health (författare)

P-glycoprotein in intestines, liver, kidney and lymphocytes in horse

Artikel/kapitelEngelska2009

Förlag, utgivningsår, omfång ...

Wiley,2009
Wiley: 12 months,2024

Nummerbeteckningar

LIBRIS-ID:oai:slubar.slu.se:32818
https://res.slu.se/id/publ/32818URI
https://doi.org/10.1111/j.1365-2885.2008.01017.xDOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

P-glycoprotein (P-gp) is an important drug transporter, which is expressed in a variety of cells, such as the intestinal enterocytes, the hepatocytes, the renal tubular cells and the intestinal and peripheral blood lymphocytes. We have studied the localization and the gene and protein expression of P-gp in these cells in horse. In addition we have compared the protein sequence of P-gp in horse with the protein sequences of P-gp in several other species. Real time RT-PCR and Western blot showed gene and protein expression of horse P-gp in all parts of the intestines, but there was no strict correlation between these parameters. Immunohistochemistry showed localization of P-gp in the apical cell membranes of the enterocytes and, in addition, staining was observed in the intestinal intraepithelial and lamina propria lymphocytes. Peripheral blood lymphocytes also stained for P-gp, and gene and protein expression of P-gp were observed in these cells. There was a high gene and protein expression of P-gp in the liver, with P-gp-immunoreactivity in the bile canalicular membranes of the hepatocytes. Gene and protein expression of P-gp were found in the kidney with localization of the protein in different parts of the nephrons. Protein sequence alignment showed that horse P-gp has two amino acid insertions at the N-terminal region of the protein, which are not present in several other species examined. One of these is a 99 amino acid long sequence inserted at amino acid positions 23-121 from the N-terminal. The other is a six amino acid long sequence present at the amino acid positions 140-145 from the N-terminal. The results of the present study indicate that P-gp has an important function for oral bioavailability, distribution and excretion of substrate compounds in horse.

Ämnesord och genrebeteckningar

LANTBRUKSVETENSKAPER Husdjursvetenskap hsv//swe
AGRICULTURAL SCIENCES Animal and Dairy Sience hsv//eng
LANTBRUKSVETENSKAPER Veterinärmedicin hsv//swe
AGRICULTURAL SCIENCES Veterinary Science hsv//eng

Biuppslag (personer, institutioner, konferenser, titlar ...)

Tallkvist, JonasSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health(Swepub:slu)49777 (författare)
Tjälve, HansSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health(Swepub:slu)50222 (författare)
Larsson, PiaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health(Swepub:slu)49779 (författare)
Sveriges lantbruksuniversitetInst för biomedicin och veterinär folkhälsovetenskap (creator_code:org_t)
Sveriges lantbruksuniversitet

Sammanhörande titlar

Ingår i:Journal of Veterinary Pharmacology and Therapeutics: Wiley32, s. 167-1760140-77831365-2885

Internetlänk

Hitta via bibliotek

Journal of Veterinary Pharmacology and Therapeutics (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Tyden, Eva; Tallkvist, Jonas; Tjälve, Hans; Larsson, Pia

Om ämnet

LANTBRUKSVETENSKAPER: LANTBRUKSVETENSK ...; och Husdjursvetenska ...

LANTBRUKSVETENSKAPER: LANTBRUKSVETENSK ...; och Veterinärmedicin

Artiklar i publikationen: Journal of Veter ...

Av lärosätet: Sveriges Lantbruksuniversitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se