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Extensive uptake of...
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
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- Lindström, Veronica (författare)
- Uppsala universitet,Geriatrik,Molecular geriatrics
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- Gustafsson, Gabriel (författare)
- Uppsala universitet,Geriatrik,Molecular Geriatrics
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- Sanders, Laurie H (författare)
- Univ Pittsburgh, Pittsburgh Inst Neurodegenerat Dis, Dept Neurol, Pittsburgh, PA 15260 USA
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- Howlett, Evan H (författare)
- Univ Pittsburgh, Pittsburgh Inst Neurodegenerat Dis, Dept Neurol, Pittsburgh, PA 15260 USA
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- Sigvardson, Jessica (författare)
- BioArctic AB, Warfvinges Vag 35, S-11251 Stockholm, Sweden
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- Kasrayan, Alex (författare)
- BioArctic AB, Warfvinges Vag 35, S-11251 Stockholm, Sweden
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- Ingelsson, Martin (författare)
- Uppsala universitet,Geriatrik,Molecular geriatrics
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- Bergström, Joakim (författare)
- Uppsala universitet,Geriatrik,Molecular geriatrics
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- Erlandsson, Anna, 1962- (författare)
- Uppsala universitet,Geriatrik,Molecular geriatrics
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431 .- 1095-9327. ; 82, s. 143-156
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The presence of Lewy bodies, mainly consisting of aggregated α-synuclein, is a pathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The α-synuclein inclusions are predominantly found in neurons, but also appear frequently in astrocytes. However, the pathological significance of α-synuclein inclusions in astrocytes and the capacity of glial cells to clear toxic α-synuclein species remain unknown. In the present study we investigated uptake, degradation and toxic effects of oligomeric α-synuclein in a co-culture system of primary neurons, astrocytes and oligodendrocytes. Alpha-synuclein oligomers were found to co-localize with the glial cells and the astrocytes were found to internalize particularly large amounts of the protein. Following ingestion, the astrocytes started to degrade the oligomers via the lysosomal pathway but, due to incomplete digestion, large intracellular deposits remained. Moreover, the astrocytes displayed mitochondrial abnormalities. Taken together, our data indicate that astrocytes play an important role in the clearance of toxic α-synuclein species from the extracellular space. However, when their degrading capacity is overburdened, α-synuclein deposits can persist and result in detrimental cellular processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Nyckelord
- Astrocytes
- Glia
- Mitochondria
- Oligodendrocytes
- Parkinson's disease
- α-Synuclein oligomers
- Medical Science
- Medicinsk vetenskap
- Biology with specialization in Molecular Cell Biology
- Biologi med inriktning mot molekylär cellbiologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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