Computed tomography evaluation of intra-articular mineralization in feline stifle joints

• COMPUTEDTOMOGRAPHYEVALUATIONOFINTRA-ARTICULARMINERALIZATIONINFELINESTIFLEJOINTSA.Corin,C.Ley,A.Leijon,C.J.Ley.FromtheDepartmentofClinicalSciences(Corin,Ley)andDepartmentofBiomedicalSciencesandVeterinaryPublicHealth,SwedishUniversityofAgriculturalSciences,UppsalaSE-75007,Sweden(Ley,Leijon).Introduction/Purpose:Intra-articularmineralization(IAM)isacommonradiographicfndingincatstifle.TheetiologyofIAMremainsunknown,althoughseveralstudieshaveshownacorrela-tionwithosteoarthritis(OA).Theaimsofthisstudywereto(a)investigatecorrela-ionsbetweenIAMandtheparametersage,sex,catsize,andsesamoidvolumes;(b)investigatepossiblecorrelationsbetweenIAMandOAcartilagelesions;(c)comparethesizeofIAMincomputedtomography(CT)imagesandradiographsofthesamestifle.Methods:Rightstifljointsfrom28cats(16MN,9FN,3F),age1-23years(mean9.9),weight2.1-7.3kg(mean3.9)thatdiedforreasonsunrelatedtothestudywereexaminedpostmortemwithCTandradiography,followedbymacroscopicandmicroscopicevaluationofjointtissues.Femurvolume,IAMvolume,andsesamoidmineralizedtissuevolumesweremeasuredinCTimages.Intra-articularmineralizationareawasmeasuredinmediolateralprojectionradiographsandcategorizedaccordingtoapublishedstudy.1Allmeasurementsweredonebyoneauthor(C.J.L.).ThearticularcartilagewasgradedforpresenceofOAlesionsbytwoauthors(C.L.,A.L.)usingconsensusandwithlightmicroscopyhistology.OsteoarthritisgradeswerecomparedwiththepresenceandvolumeofIAMinCTimages.Regressionanalysis,t-tests,andFisherexacttestswereusedandvaluesofP<0.05wereconsideredsignificantResults:In13of28jointsIAMweredetectedandallexceptonewerelocatedwithinthemedialmeniscus.Whenmeasuredinradiographs11of13IAMweresmall(<2.25mm2),twowereintermediate,andnoIAMwerelarge(>6.25mm2).Osteoarthritiswasdetectedin26jointsandofthese13hadminimalOA,11hadmildOA,andtwohadmoderateOA.NosignificancorrelationwasfoundbetweenIAMandgradeofOAcartilagelesions,femurvolume,lateralfabellavolume,poplitealsesamoidvolume,patellavolume,sex,orageofthecats.Themedialfabellawasmineralizedin16cats,eightofwhichhadIAM.ThemedialfabellawassignificantllargerincatswithIAM.AreaofIAMinradiographshadsignificancorrelationswithCTvolumemeasurements.Discussion/Conclusions:Intra-articularmineralizationswerenotaconsistentfindininstifljointswithminimal,mild,andmoderateOAcartilagelesions.SmallmineralizationsinthefelinemedialmeniscusmaydevelopforreasonsotherthanOAandsmallIAMareunlikelytobeareliableindicationoffelinestiflOA.ThereasonforcatswithIAMhavinglargermineralizedmedialfabellaisnotclear.ItseemsreasonabletousemeasurementsfrommediolateralprojectionradiographstoestimateIAMsizeinfelinestifljoints.References:1.VossK,etal.JFelineMedSurg2015;Epubaheadofprint.

Ämnesord

LANTBRUKSVETENSKAPER  -- Veterinärmedicin -- Patobiologi (hsv//swe)

AGRICULTURAL SCIENCES  -- Veterinary Science -- Pathobiology (hsv//eng)

LANTBRUKSVETENSKAPER  -- Veterinärmedicin -- Klinisk vetenskap (hsv//swe)

AGRICULTURAL SCIENCES  -- Veterinary Science -- Clinical Science (hsv//eng)

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