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Study of 300,486 in...
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
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Davies, G. (author)
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Lam, M. (author)
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Harris, S. E. (author)
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show more...
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Trampush, J. W. (author)
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Luciano, M. (author)
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Hill, W. D. (author)
-
Hagenaars, S. P. (author)
-
Ritchie, S. J. (author)
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Marioni, R. E. (author)
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Fawns-Ritchie, C. (author)
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Liewald, D. C. M. (author)
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Okely, J. A. (author)
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Ahola-Olli, A. V. (author)
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Barnes, C. L. K. (author)
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Bertram, L. (author)
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Bis, J. C. (author)
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Burdick, K. E. (author)
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Christoforou, A. (author)
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Derosse, P. (author)
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Djurovic, S. (author)
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Espeseth, T. (author)
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Giakoumaki, S. (author)
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Giddaluru, S. (author)
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Gustavson, D. E. (author)
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Hayward, C. (author)
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Hofer, E. (author)
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Ikram, M. A. (author)
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- Karlsson, R. (author)
- Karolinska Institutet
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Knowles, E. (author)
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Lahti, J. (author)
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Leber, M. (author)
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Li, S. (author)
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Mather, K. A. (author)
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Melle, I. (author)
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Morris, D. (author)
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Oldmeadow, C. (author)
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Palviainen, T. (author)
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Payton, A. (author)
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Pazoki, R. (author)
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Petrovic, K. (author)
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Reynolds, C. A. (author)
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Sargurupremraj, M. (author)
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Scholz, M. (author)
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Smith, J. A. (author)
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Smith, A. V. (author)
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Terzikhan, N. (author)
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Thalamuthu, A. (author)
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Trompet, S. (author)
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Van Der Lee, S. J. (author)
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Ware, E. B. (author)
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Windham, B. G. (author)
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Wright, M. J. (author)
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Yang, J. (author)
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Yu, J. (author)
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Ames, D. (author)
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Amin, N. (author)
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Amouyel, P. (author)
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Andreassen, O. A. (author)
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Armstrong, N. J. (author)
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Assareh, A. A. (author)
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Attia, J. R. (author)
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Attix, D. (author)
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Avramopoulos, D. (author)
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Bennett, D. A. (author)
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Böhmer, A. C. (author)
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Boyle, P. A. (author)
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Brodaty, H. (author)
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Campbell, H. (author)
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Cannon, T. D. (author)
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Cirulli, E. T. (author)
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Congdon, E. (author)
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Conley, E. D. (author)
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Corley, J. (author)
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Cox, S. R. (author)
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Dale, A. M. (author)
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Dehghan, A. (author)
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Dick, D. (author)
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Dickinson, D. (author)
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Eriksson, J. G. (author)
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Evangelou, E. (author)
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Faul, J. D. (author)
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Ford, I. (author)
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Freimer, N. A. (author)
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Gao, H. (author)
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Giegling, I. (author)
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Gillespie, N. A. (author)
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Gordon, S. D. (author)
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Gottesman, R. F. (author)
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Griswold, M. E. (author)
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Gudnason, V. (author)
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Harris, T. B. (author)
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Hartmann, A. M. (author)
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Hatzimanolis, A. (author)
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Heiss, G. (author)
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Holliday, E. G. (author)
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Joshi, P. K. (author)
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Kähönen, M. (author)
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Kardia, S. L. R. (author)
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- Karlsson, Ida K. (author)
- Karolinska Institutet
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Kleineidam, L. (author)
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Knopman, D. S. (author)
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Kochan, N. A. (author)
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Konte, B. (author)
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Kwok, J. B. (author)
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Le Hellard, S. (author)
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Lee, T. (author)
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Lehtimäki, T. (author)
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Li, S. -C (author)
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Liu, T. (author)
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Koini, M. (author)
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London, E. (author)
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Longstreth, W.T., Jr. (author)
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Lopez, O. L. (author)
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Loukola, A. (author)
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Luck, T. (author)
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Lundervold, A. J. (author)
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- Lundquist, Anders, 1978- (author)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Statistik
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- Lyytikäinen, L. -P (author)
- Karolinska Institutet
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Martin, N. G. (author)
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Montgomery, G. W. (author)
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Murray, A. D. (author)
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Need, A. C. (author)
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Noordam, R. (author)
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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Ollier, W. (author)
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- Papenberg, G. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Max Planck Institute for Human Development, Germany
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Pattie, A. (author)
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Polasek, O. (author)
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Poldrack, R. A. (author)
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Psaty, B. M. (author)
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Reppermund, S. (author)
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Riedel-Heller, S. G. (author)
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Rose, R. J. (author)
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Rotter, J. I. (author)
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Roussos, P. (author)
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Rovio, S. P. (author)
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Saba, Y. (author)
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Sabb, F. W. (author)
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Sachdev, P. S. (author)
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Satizabal, C. L. (author)
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Schmid, M. (author)
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Scott, R. J. (author)
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Scult, M. A. (author)
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Simino, J. (author)
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Slagboom, P. E. (author)
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Smyrnis, N. (author)
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Soumaré, A. (author)
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Stefanis, N. C. (author)
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Stott, D. J. (author)
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Straub, R. E. (author)
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Sundet, K. (author)
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Taylor, A. M. (author)
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Taylor, K. D. (author)
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Tzoulaki, I. (author)
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Tzourio, C. (author)
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Uitterlinden, A. (author)
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Vitart, V. (author)
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Voineskos, A. N. (author)
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Kaprio, J. (author)
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Wagner, M. (author)
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Wagner, H. (author)
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Weinhold, L. (author)
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Wen, K. H. (author)
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Widen, E. (author)
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Yang, Q. (author)
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Zhao, W. (author)
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Adams, H. H. H. (author)
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Arking, D. E. (author)
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Bilder, R. M. (author)
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Bitsios, P. (author)
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Boerwinkle, E. (author)
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Chiba-Falek, O. (author)
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Corvin, A. (author)
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De Jager, P. L. (author)
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Debette, S. (author)
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Donohoe, G. (author)
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Elliott, P. (author)
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Fitzpatrick, A. L. (author)
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Gill, M. (author)
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Glahn, D. C. (author)
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- Hägg, S. (author)
- Karolinska Institutet
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Hansell, N. K. (author)
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Hariri, A. R. (author)
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Ikram, M. K. (author)
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Jukema, J. W. (author)
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Vuoksimaa, E. (author)
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Keller, M. C. (author)
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Kremen, W. S. (author)
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Launer, L. (author)
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Lindenberger, U. (author)
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Palotie, A. (author)
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Pedersen, N. L. (author)
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Pendleton, N. (author)
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Porteous, D. J. (author)
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Räikkönen, K. (author)
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Raitakari, O. T. (author)
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Ramirez, A. (author)
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Reinvang, I. (author)
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Rudan, I. (author)
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Rujescu, D. (author)
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Schmidt, R. (author)
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Schmidt, H. (author)
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Schofield, P. W. (author)
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Schofield, P. R. (author)
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Starr, J. M. (author)
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Steen, V. M. (author)
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Trollor, J. N. (author)
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Turner, S. T. (author)
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Van Duijn, C. M. (author)
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Villringer, A. (author)
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Weinberger, D. R. (author)
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Weir, D. R. (author)
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Wilson, J. F. (author)
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Malhotra, A. (author)
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McIntosh, A. M. (author)
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Gale, C. R. (author)
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Seshadri, S. (author)
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Mosley, T.H., Jr. (author)
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Bressler, J. (author)
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Lencz, T. (author)
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Deary, I. J. (author)
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show less...
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(creator_code:org_t)
- 2018-05-29
- 2018
- English.
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1
- Related links:
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https://doi.org/10.1...
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https://www.nature.c...
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https://umu.diva-por... (primary) (Raw object)
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https://umu.diva-por...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- brain
- cognition
- data set
- genetic analysis
- genome
- identification method
- nervous system disorder
- adolescent
- adult
- aged
- angina pectoris
- Article
- brain cortex
- controlled study
- gene expression
- gene locus
- genetic correlation
- grip strength
- heart infarction
- human
- hypertension
- longevity
- lung cancer
- major clinical study
- major depression
- osteoarthritis
- response time
- vision
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Davies, G.
-
Lam, M.
-
Harris, S. E.
-
Trampush, J. W.
-
Luciano, M.
-
Hill, W. D.
-
show more...
-
Hagenaars, S. P.
-
Ritchie, S. J.
-
Marioni, R. E.
-
Fawns-Ritchie, C ...
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Liewald, D. C. M ...
-
Okely, J. A.
-
Ahola-Olli, A. V ...
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Barnes, C. L. K.
-
Bertram, L.
-
Bis, J. C.
-
Burdick, K. E.
-
Christoforou, A.
-
Derosse, P.
-
Djurovic, S.
-
Espeseth, T.
-
Giakoumaki, S.
-
Giddaluru, S.
-
Gustavson, D. E.
-
Hayward, C.
-
Hofer, E.
-
Ikram, M. A.
-
Karlsson, R.
-
Knowles, E.
-
Lahti, J.
-
Leber, M.
-
Li, S.
-
Mather, K. A.
-
Melle, I.
-
Morris, D.
-
Oldmeadow, C.
-
Palviainen, T.
-
Payton, A.
-
Pazoki, R.
-
Petrovic, K.
-
Reynolds, C. A.
-
Sargurupremraj, ...
-
Scholz, M.
-
Smith, J. A.
-
Smith, A. V.
-
Terzikhan, N.
-
Thalamuthu, A.
-
Trompet, S.
-
Van Der Lee, S. ...
-
Ware, E. B.
-
Windham, B. G.
-
Wright, M. J.
-
Yang, J.
-
Yu, J.
-
Ames, D.
-
Amin, N.
-
Amouyel, P.
-
Andreassen, O. A ...
-
Armstrong, N. J.
-
Assareh, A. A.
-
Attia, J. R.
-
Attix, D.
-
Avramopoulos, D.
-
Bennett, D. A.
-
Böhmer, A. C.
-
Boyle, P. A.
-
Brodaty, H.
-
Campbell, H.
-
Cannon, T. D.
-
Cirulli, E. T.
-
Congdon, E.
-
Conley, E. D.
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Corley, J.
-
Cox, S. R.
-
Dale, A. M.
-
Dehghan, A.
-
Dick, D.
-
Dickinson, D.
-
Eriksson, J. G.
-
Evangelou, E.
-
Faul, J. D.
-
Ford, I.
-
Freimer, N. A.
-
Gao, H.
-
Giegling, I.
-
Gillespie, N. A.
-
Gordon, S. D.
-
Gottesman, R. F.
-
Griswold, M. E.
-
Gudnason, V.
-
Harris, T. B.
-
Hartmann, A. M.
-
Hatzimanolis, A.
-
Heiss, G.
-
Holliday, E. G.
-
Joshi, P. K.
-
Kähönen, M.
-
Kardia, S. L. R.
-
Karlsson, Ida K.
-
Kleineidam, L.
-
Knopman, D. S.
-
Kochan, N. A.
-
Konte, B.
-
Kwok, J. B.
-
Le Hellard, S.
-
Lee, T.
-
Lehtimäki, T.
-
Li, S. -C
-
Liu, T.
-
Koini, M.
-
London, E.
-
Longstreth, W.T. ...
-
Lopez, O. L.
-
Loukola, A.
-
Luck, T.
-
Lundervold, A. J ...
-
Lundquist, Ander ...
-
Lyytikäinen, L. ...
-
Martin, N. G.
-
Montgomery, G. W ...
-
Murray, A. D.
-
Need, A. C.
-
Noordam, R.
-
Nyberg, Lars, 19 ...
-
Ollier, W.
-
Papenberg, G.
-
Pattie, A.
-
Polasek, O.
-
Poldrack, R. A.
-
Psaty, B. M.
-
Reppermund, S.
-
Riedel-Heller, S ...
-
Rose, R. J.
-
Rotter, J. I.
-
Roussos, P.
-
Rovio, S. P.
-
Saba, Y.
-
Sabb, F. W.
-
Sachdev, P. S.
-
Satizabal, C. L.
-
Schmid, M.
-
Scott, R. J.
-
Scult, M. A.
-
Simino, J.
-
Slagboom, P. E.
-
Smyrnis, N.
-
Soumaré, A.
-
Stefanis, N. C.
-
Stott, D. J.
-
Straub, R. E.
-
Sundet, K.
-
Taylor, A. M.
-
Taylor, K. D.
-
Tzoulaki, I.
-
Tzourio, C.
-
Uitterlinden, A.
-
Vitart, V.
-
Voineskos, A. N.
-
Kaprio, J.
-
Wagner, M.
-
Wagner, H.
-
Weinhold, L.
-
Wen, K. H.
-
Widen, E.
-
Yang, Q.
-
Zhao, W.
-
Adams, H. H. H.
-
Arking, D. E.
-
Bilder, R. M.
-
Bitsios, P.
-
Boerwinkle, E.
-
Chiba-Falek, O.
-
Corvin, A.
-
De Jager, P. L.
-
Debette, S.
-
Donohoe, G.
-
Elliott, P.
-
Fitzpatrick, A. ...
-
Gill, M.
-
Glahn, D. C.
-
Hägg, S.
-
Hansell, N. K.
-
Hariri, A. R.
-
Ikram, M. K.
-
Jukema, J. W.
-
Vuoksimaa, E.
-
Keller, M. C.
-
Kremen, W. S.
-
Launer, L.
-
Lindenberger, U.
-
Palotie, A.
-
Pedersen, N. L.
-
Pendleton, N.
-
Porteous, D. J.
-
Räikkönen, K.
-
Raitakari, O. T.
-
Ramirez, A.
-
Reinvang, I.
-
Rudan, I.
-
Rujescu, D.
-
Schmidt, R.
-
Schmidt, H.
-
Schofield, P. W.
-
Schofield, P. R.
-
Starr, J. M.
-
Steen, V. M.
-
Trollor, J. N.
-
Turner, S. T.
-
Van Duijn, C. M.
-
Villringer, A.
-
Weinberger, D. R ...
-
Weir, D. R.
-
Wilson, J. F.
-
Malhotra, A.
-
McIntosh, A. M.
-
Gale, C. R.
-
Seshadri, S.
-
Mosley, T.H., Jr ...
-
Bressler, J.
-
Lencz, T.
-
Deary, I. J.
-
show less...
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- MEDICAL AND HEALTH SCIENCES
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- By the university
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Jönköping University
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Umeå University
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Stockholm University
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Karolinska Institutet