Search: (WFRF:(Amundadottir Laufey)) pers:(Cotterchio Michelle) >
Genome-wide associa...
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.
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Amundadottir, Laufey (author)
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Kraft, Peter (author)
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Stolzenberg-Solomon, Rachael Z (author)
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show more...
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Fuchs, Charles S (author)
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Petersen, Gloria M (author)
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Arslan, Alan A (author)
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Bueno-de-Mesquita, H Bas (author)
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Gross, Myron (author)
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Helzlsouer, Kathy (author)
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Jacobs, Eric J (author)
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Lacroix, Andrea (author)
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Zheng, Wei (author)
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Albanes, Demetrius (author)
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Bamlet, William (author)
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Berg, Christine D (author)
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Berrino, Franco (author)
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Bingham, Sheila (author)
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Buring, Julie E (author)
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Bracci, Paige M (author)
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Canzian, Federico (author)
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Clavel-Chapelon, Françoise (author)
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Clipp, Sandra (author)
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Cotterchio, Michelle (author)
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de Andrade, Mariza (author)
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Duell, Eric J (author)
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Fox Jr, John W (author)
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Gallinger, Steven (author)
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Gaziano, J Michael (author)
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Giovannucci, Edward L (author)
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Goggins, Michael (author)
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González, Carlos A (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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Hankinson, Susan E (author)
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Hassan, Manal (author)
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Holly, Elizabeth A (author)
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Hunter, David J (author)
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Hutchinson, Amy (author)
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Jackson, Rebecca (author)
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Jacobs, Kevin B (author)
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Jenab, Mazda (author)
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Kaaks, Rudolf (author)
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Klein, Alison P (author)
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Kooperberg, Charles (author)
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Kurtz, Robert C (author)
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Li, Donghui (author)
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Lynch, Shannon M (author)
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Mandelson, Margaret (author)
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McWilliams, Robert R (author)
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Mendelsohn, Julie B (author)
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Michaud, Dominique S (author)
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Olson, Sara H (author)
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Overvad, Kim (author)
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Patel, Alpa V (author)
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Peeters, Petra H M (author)
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Rajkovic, Aleksandar (author)
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Riboli, Elio (author)
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Risch, Harvey A (author)
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Shu, Xiao-Ou (author)
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Thomas, Gilles (author)
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Tobias, Geoffrey S (author)
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Trichopoulos, Dimitrios (author)
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Van Den Eeden, Stephen K (author)
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Virtamo, Jarmo (author)
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Wactawski-Wende, Jean (author)
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Wolpin, Brian M (author)
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Yu, Herbert (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Chanock, Stephen J (author)
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Hartge, Patricia (author)
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Hoover, Robert N (author)
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(creator_code:org_t)
- 2009-08-02
- 2009
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41, s. 986-990
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Amundadottir, La ...
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Kraft, Peter
-
Stolzenberg-Solo ...
-
Fuchs, Charles S
-
Petersen, Gloria ...
-
Arslan, Alan A
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show more...
-
Bueno-de-Mesquit ...
-
Gross, Myron
-
Helzlsouer, Kath ...
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Jacobs, Eric J
-
Lacroix, Andrea
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Zheng, Wei
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Albanes, Demetri ...
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Bamlet, William
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Berg, Christine ...
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Berrino, Franco
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Bingham, Sheila
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Buring, Julie E
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Bracci, Paige M
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Canzian, Federic ...
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Clavel-Chapelon, ...
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Clipp, Sandra
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Cotterchio, Mich ...
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de Andrade, Mari ...
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Duell, Eric J
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Fox Jr, John W
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Gallinger, Steve ...
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Gaziano, J Micha ...
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Giovannucci, Edw ...
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Goggins, Michael
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González, Carlos ...
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Hallmans, Göran
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Hankinson, Susan ...
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Hassan, Manal
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Holly, Elizabeth ...
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Hunter, David J
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Hutchinson, Amy
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Jackson, Rebecca
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Jacobs, Kevin B
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Jenab, Mazda
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Kaaks, Rudolf
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Klein, Alison P
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Kooperberg, Char ...
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Kurtz, Robert C
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Li, Donghui
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Lynch, Shannon M
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Mandelson, Marga ...
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McWilliams, Robe ...
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Mendelsohn, Juli ...
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Michaud, Dominiq ...
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Olson, Sara H
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Overvad, Kim
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Patel, Alpa V
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Peeters, Petra H ...
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Rajkovic, Aleksa ...
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Riboli, Elio
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Risch, Harvey A
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Shu, Xiao-Ou
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Thomas, Gilles
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Tobias, Geoffrey ...
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Trichopoulos, Di ...
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Van Den Eeden, S ...
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Virtamo, Jarmo
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Wactawski-Wende, ...
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Wolpin, Brian M
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Yu, Herbert
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Yu, Kai
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Zeleniuch-Jacquo ...
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Chanock, Stephen ...
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Hartge, Patricia
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Hoover, Robert N
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show less...
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University