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Sökning: (WFRF:(Bauzá Thorbrügge Marco)) > (2024) > Adiponectin stimula...

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FältnamnIndikatorerMetadata
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003SwePub
008231214s2024 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:154496510
009oai:gup.ub.gu.se/332282
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-234702 URI
0247 a https://doi.org/10.1016/j.metabol.2023.1557162 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1544965102 URI
0247 a https://gup.ub.gu.se/publication/3322822 URI
040 a (SwePub)hisd (SwePub)kid (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bauzá-Thorbrügge, Marcou Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xbauzm
2451 0a Adiponectin stimulates Sca1+CD34−-adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue
264 1b Elsevier,c 2024
338 a electronic2 rdacarrier
500 a CC BY 4.0 DEED© 2023 The AuthorsCorrespondence Address: I. Wernstedt Asterholm; Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Medicinaregatan 11, PO Box 432, SE-405 30, Sweden; email: IWA@neuro.gu.se; CODEN: METAA
520 a Background: The adipocyte hormone adiponectin improves insulin sensitivity and there is an inverse correlation between adiponectin levels and type-2 diabetes risk. Previous research shows that adiponectin remodels the adipose tissue into a more efficient metabolic sink. For instance, mice that overexpress adiponectin show increased capacity for hyperplastic adipose tissue expansion as evident from smaller and metabolically more active white adipocytes. In contrast, the brown adipose tissue (BAT) of these mice looks “whiter” possibly indicating reduced metabolic activity. Here, we aimed to further establish the effect of adiponectin on adipose tissue expansion and adipocyte mitochondrial function as well as to unravel mechanistic aspects in this area. Methods: Brown and white adipose tissues from adiponectin overexpressing (APN tg) mice and littermate wildtype controls, housed at room and cold temperature, were studied by histological, gene/protein expression and flow cytometry analyses. Metabolic and mitochondrial functions were studied by radiotracers and Seahorse-based technology. In addition, mitochondrial function was assessed in cultured adiponectin deficient adipocytes from APN knockout and heterozygote mice. Results: APN tg BAT displayed increased proliferation prenatally leading to enlarged BAT. Postnatally, APN tg BAT turned whiter than control BAT, confirming previous reports. Furthermore, elevated adiponectin augmented the sympathetic innervation/activation within adipose tissue. APN tg BAT displayed reduced metabolic activity and reduced mitochondrial oxygen consumption rate (OCR). In contrast, APN tg inguinal white adipose tissue (IWAT) displayed enhanced metabolic activity. These metabolic differences between genotypes were apparent also in cultured adipocytes differentiated from BAT and IWAT stroma vascular fraction, and the OCR was reduced in both brown and white APN heterozygote adipocytes. In both APN tg BAT and IWAT, the mesenchymal stem cell-related genes were upregulated along with an increased abundance of Lineage−Sca1+CD34− “beige-like” adipocyte precursor cells. In vitro, the adiponectin receptor agonist Adiporon increased the expression of the proliferation marker Pcna and decreased the expression of Cd34 in Sca1+ mesenchymal stem cells. Conclusions: We propose that the seemingly opposite effect of adiponectin on BAT and IWAT is mediated by a common mechanism; while reduced adiponectin levels are linked to lower adipocyte OCR, elevated adiponectin levels stimulate expansion of adipocyte precursor cells that produce adipocytes with intrinsically higher metabolic rate than classical white but lower metabolic rate than classical brown adipocytes. Moreover, adiponectin can modify the adipocytes' metabolic activity directly and by enhancing the sympathetic innervation within a fat depot. 
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
653 a Adipocyte
653 a Adipocyte precursor cell
653 a Adiponectin
653 a Brown adipose tissue
653 a Mitochondria
653 a White adipose tissue
653 a Translationell medicin TRIM
653 a Translational Medicine TRIM
7001 a Vujičić, Milicau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xvujim
7001 a Chanclón, Belénu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut
7001 a Palsdottir, Vilborg,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xpalvi
7001 a Pillon, Nicolas J.u Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden4 aut
7001 a Benrick, Anna,d 1979-u Gothenburg University,Göteborgs universitet,Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Unit for Metabolic Physiology, Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden,Translationell medicin TRIM, Translational Medicine TRIM,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xbannl
7001 a Wernstedt Asterholm, Ingridu Unit for Metabolic Physiology, Department of Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden4 aut0 (Swepub:gu)xwerni
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi4 org
7730 t Metabolismd : Elsevierg 151q 151x 0026-0495x 1532-8600
8564 u https://doi.org/10.1016/j.metabol.2023.155716y Fulltext
8564 u https://his.diva-portal.org/smash/get/diva2:1819512/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23470
8564 8u https://doi.org/10.1016/j.metabol.2023.155716
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:154496510
8564 8u https://gup.ub.gu.se/publication/332282

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