Search: (WFRF:(Berg Christine D)) pers:(Stevens Victoria L) > (2020-2023) > Design and methodol...
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000 | 11938naa a2201045 4500 | |
001 | oai:DiVA.org:umu-201376 | |
003 | SwePub | |
008 | 221130s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2013762 URI |
024 | 7 | a https://doi.org/10.1016/j.annepidem.2022.10.0142 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Robbins, Hilary A.u Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
245 | 1 0 | a Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program |
264 | 1 | b Elsevier,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a The Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) program is an NCI-funded initiative with an objective to develop tools to optimize low-dose CT (LDCT) lung cancer screening. Here, we describe the rationale and design for the Risk Biomarker and Nodule Malignancy projects within INTEGRAL. The overarching goal of these projects is to systematically investigate circulating protein markers to include on a panel for use (i) pre-LDCT, to identify people likely to benefit from screening, and (ii) post-LDCT, to differentiate benign versus malignant nodules. To identify informative proteins, the Risk Biomarker project measured 1161 proteins in a nested-case control study within 2 prospective cohorts (n = 252 lung cancer cases and 252 controls) and replicated associations for a subset of proteins in 4 cohorts (n = 479 cases and 479 controls). Eligible participants had a current or former history of smoking and cases were diagnosed up to 3 years following blood draw. The Nodule Malignancy project measured 1078 proteins among participants with a heavy smoking history within four LDCT screening studies (n = 425 cases diagnosed up to 5 years following blood draw, 430 benign-nodule controls, and 398 nodule-free controls). The INTEGRAL panel will enable absolute quantification of 21 proteins. We will evaluate its performance in the Risk Biomarker project using a case-cohort study including 14 cohorts (n = 1696 cases and 2926 subcohort representatives), and in the Nodule Malignancy project within five LDCT screening studies (n = 675 cases, 680 benign-nodule controls, and 648 nodule-free controls). Future progress to advance lung cancer early detection biomarkers will require carefully designed validation, translational, and comparative studies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a biomarker discovery and validation | |
653 | a biomarkers | |
653 | a early detection | |
653 | a Lung cancer screening | |
653 | a nodule malignancy | |
653 | a risk prediction | |
653 | a study design | |
700 | 1 | a Alcala, Karineu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Moez, Elham Khodayariu Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada4 aut |
700 | 1 | a Guida, Florenceu Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Thomas, Serau Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada4 aut |
700 | 1 | a Zahed, Hanau Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Warkentin, Matthew T.u Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada4 aut |
700 | 1 | a Smith-Byrne, Karlu Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Brhane, Yonathanu Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada4 aut |
700 | 1 | a Muller, Davidu Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom4 aut |
700 | 1 | a Feng, Xiaoshuangu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Aldrich, Melinda C.u Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut |
700 | 1 | a Arslan, Alan A.u Departments of Obstetrics and Gynecology and Population Health, New York University Grossman School of Medicine, NY, New York, United States4 aut |
700 | 1 | a Bassett, Julieu Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia4 aut |
700 | 1 | a Berg, Christine D.u Retired, MD, Bethesda4 aut |
700 | 1 | a Cai, Qiuyinu Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut |
700 | 1 | a Chen, Chuu Program in Epidemiology and the Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Davies, Michael P.A.u Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut |
700 | 1 | a Diergaarde, Brendau Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Centre, PA, Pittsburgh, United States4 aut |
700 | 1 | a Field, John K.u Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut |
700 | 1 | a Freedman, Neal D.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Huang, Wen-Yiu Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Jones, Michaelu Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom4 aut |
700 | 1 | a Koh, Woon-Puayu Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore4 aut |
700 | 1 | a Lam, Stephenu Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada4 aut |
700 | 1 | a Lan, Qingu Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Langhammer, Arnulfu HUNT Research Center, Department of Public Health and Nursing, NTNU Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway4 aut |
700 | 1 | a Liao, Linda M.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Liu, Geoffreyu Computational Biology and Medicine Program, Princess Margaret Cancer Center, Toronto, Canada4 aut |
700 | 1 | a Malekzadeh, Rezau Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran4 aut |
700 | 1 | a Milne, Roger L.u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Australia; School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia4 aut |
700 | 1 | a Montuenga, Luis M.u Center of Applied Medical Research (CIMA) and Schools of Sciences and Medicine, University of Navarra, Pamplona, Spain; IDISNA, Pamplona, Spain; CIBERONC, Madrid, Spain4 aut |
700 | 1 | a Rohan, Thomasu Department of Epidemiology & Population Health, Albert Einstein College of Medicine, NY, Bronx, United States4 aut |
700 | 1 | a Sesso, Howard D.u Brigham and Women's Hospital, Harvard Medical School, MA, Boston4 aut |
700 | 1 | a Severi, Gianlucau Inserm, Université Paris-Saclay, Villejuif, France4 aut |
700 | 1 | a Sheikh, Mahdiu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Sinha, Rashmiu Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a Shu, Xiao-Ouu Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut |
700 | 1 | a Stevens, Victoria L.u Rollins School of Public Health, Emory University, GA, Atlanta4 aut |
700 | 1 | a Tammemägi, Martin C.u Department of Health Sciences, Brock University, ON, St. Cathaarines, Canada; Prevention and Cancer Control, Ontario Health, ON, Toronto, Canada4 aut |
700 | 1 | a Tinker, Lesley F.u Women's Health Initiative Clinical Coordinating Center, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore4 aut |
700 | 1 | a Wang, Yingu American Cancer Society, GA, Atlanta4 aut |
700 | 1 | a Wang, Renweiu UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States4 aut |
700 | 1 | a Weinstein, Stephanie J.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville4 aut |
700 | 1 | a White, Emilyu Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Wilson, Davidu Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States4 aut |
700 | 1 | a Yuan, Jian-Minu UPMC Hillman Cancer Centre, PA, Pittsburgh, United States; Department of Epidemiology, Graduate Schoolf of Public Health, University of Pittsburgh, PA, Pittsburgh, United States4 aut |
700 | 1 | a Zhang, Xuehongu Brigham and Women's Hospital, Harvard Medical School, MA, Boston4 aut |
700 | 1 | a Zheng, Weiu Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut |
700 | 1 | a Amos, Christopher I.u Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States4 aut |
700 | 1 | a Brennan, Paulu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Johansson, Mattiasu Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Hung, Rayjean J.u Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada4 aut |
710 | 2 | a Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, Franceb Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada4 org |
773 | 0 | t Annals of Epidemiologyd : Elsevierg 77, s. 1-12q 77<1-12x 1047-2797x 1873-2585 |
856 | 4 | u https://doi.org/10.1016/j.annepidem.2022.10.014y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1714686/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201376 |
856 | 4 8 | u https://doi.org/10.1016/j.annepidem.2022.10.014 |
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