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Sökning: (WFRF:(Brouwer Rachel M)) > (2018) > Fatty acid biomarke...

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FältnamnIndikatorerMetadata
00010204naa a2200913 4500
001oai:DiVA.org:uu-369767
003SwePub
008181217s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3697672 URI
0247 a https://doi.org/10.1371/journal.pmed.10026702 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Imamura, Fumiakiu Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England4 aut
2451 0a Fatty acid biomarkers of dairy fat consumption and incidence of type 2 diabetes :b A pooled analysis of prospective cohort studies
264 c 2018-10-10
264 1b Public Library of Science (PLoS),c 2018
338 a electronic2 rdacarrier
520 a Background We aimed to investigate prospective associations of circulating or adipose tissue odd-chain fatty acids 15: 0 and 17: 0 and trans-palmitoleic acid, t16:1n-7, as potential biomarkers of dairy fat intake, with incident type 2 diabetes (T2D). Methods and findings Sixteen prospective cohorts from 12 countries (7 from the United States, 7 from Europe, 1 from Australia, 1 from Taiwan) performed new harmonised individual-level analysis for the prospective associations according to a standardised plan. In total, 63,682 participants with a broad range of baseline ages and BMIs and 15,180 incident cases of T2D over the average of 9 years of follow-up were evaluated. Study-specific results were pooled using inverse-variance-weighted meta-analysis. Prespecified interactions by age, sex, BMI, and race/ethnicity were explored in each cohort and were meta-analysed. Potential heterogeneity by cohort-specific characteristics (regions, lipid compartments used for fatty acid assays) was assessed with metaregression. After adjustment for potential confounders, including measures of adiposity (BMI, waist circumference) and lipogenesis (levels of palmitate, tri-glycerides), higher levels of 15:0, 17:0, and t16:1n-7 were associated with lower incidence of T2D. In the most adjusted model, the hazard ratio (95% CI) for incident T2D per cohort-specific 10th to 90th percentile range of 15:0 was 0.80 (0.73-0.87); of 17:0, 0.65 (0.59-0.72); of t16:1n7, 0.82 (0.70-0.96); and of their sum, 0.71 (0.63-0.79). In exploratory analyses, similar associations for 15:0, 17:0, and the sum of all three fatty acids were present in both genders but stronger in women than in men ((pinteraction) < 0.001). Whereas studying associations with biomarkers has several advantages, as limitations, the biomarkers do not distinguish between different food sources of dairy fat (e.g., cheese, yogurt, milk), and residual confounding by unmeasured or imprecisely measured confounders may exist. Conclusions In a large meta-analysis that pooled the findings from 16 prospective cohort studies, higher levels of 15:0, 17:0, and t16:1n-7 were associated with a lower risk of T2D.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Fretts, Amandau Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA4 aut
7001 a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)matma701
7001 a Korat, Andres V. Ardissonu Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA4 aut
7001 a Yang, Wei-Sinu Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan4 aut
7001 a Lankinen, Mariau Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut
7001 a Qureshi, Waqasu Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Bowman Gray Ctr,Sect Cardiovasc Med, Winston Salem, NC 27103 USA4 aut
7001 a Helmer, Catherineu Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France4 aut
7001 a Chen, Tzu-Anu USDA ARS, Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX USA4 aut
7001 a Wong, Kerryu Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia4 aut
7001 a Bassett, Julie K.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia4 aut
7001 a Murphy, Rachelu Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Ctr Excellence Canc Prevent, Vancouver, BC, Canada4 aut
7001 a Tintle, Nathanu Dordt Coll, Dept Math & Stat, Sioux Ctr, IA USA4 aut
7001 a Yu, Chaoyu Ianu Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA4 aut
7001 a Brouwer, Ingeborg A.u Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Fac Earth & Life Sci, Dept Hlth Sci, Amsterdam, Netherlands4 aut
7001 a Chien, Kuo-Liongu Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan4 aut
7001 a Frazier-Wood, Alexis C.u USDA ARS, Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, Houston, TX USA4 aut
7001 a del Gobbo, Liana C.u Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA USA4 aut
7001 a Djousse, Lucu Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA USA4 aut
7001 a Geleijnse, Johanna M.u Wageningen Univ, Div Human Nutr, Wageningen, Netherlands4 aut
7001 a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia4 aut
7001 a de Goede, Janetteu Wageningen Univ, Div Human Nutr, Wageningen, Netherlands4 aut
7001 a Gudnason, Vilmunduru Iceland Heart Assoc Res Inst, Kopavogur, Iceland4 aut
7001 a Harris, William S.u Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA;OmegaQuant Analyt LLC, Sioux Falls, SD USA4 aut
7001 a Hodge, Allisonu Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia4 aut
7001 a Hu, Franku Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA4 aut
7001 a Koulman, Albertu Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England;Univ Cambridge, Addenbrookes Hosp, Natl Inst Hlth Res Biomed Res Ctr Core Nutr Bioma, Cambridge, England;Univ Cambridge, Addenbrookes Hosp, Natl Inst Hlth Res Biomed Res Ctr Core Metabol &, Cambridge, England;MRC, Elsie Widdowson Lab, Cambridge, England;Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland4 aut
7001 a Laakso, Markkuu Kuopio Univ Hosp, Dept Med, Kuopio, Finland4 aut
7001 a Lind, Larsu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)larslind
7001 a Lin, Hung-Juu Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan4 aut
7001 a McKnight, Barbarau Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA4 aut
7001 a Rajaobelina, Kalinau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism,Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden4 aut0 (Swepub:uu)ulfriser
7001 a Robinson, Jennifer G.u Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA USA;Univ Iowa, Dept Med, Coll Publ Hlth, Iowa City, IA 52242 USA4 aut
7001 a Samieri, Ceciliau Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France4 aut
7001 a Siscovick, David S.u New York Acad Med, New York, NY USA4 aut
7001 a Soedamah-Muthu, Sabita S.u Tilburg Univ, Ctr Res Psychol Somat Dis, Dept Med & Clin Psychol, Tilburg, Netherlands4 aut
7001 a Sotoodehnia, Nonau Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA4 aut
7001 a Sun, Qiu Harvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA4 aut
7001 a Tsai, Michael Y.u Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA4 aut
7001 a Uusitupa, Mattiu Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland4 aut
7001 a Wagenknecht, Lynne E.u Wake Forest Sch Med, Publ Hlth Sci, Winston Salem, NC USA4 aut
7001 a Wareham, Nick J.u Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England4 aut
7001 a Wu, Jason H. Y.u Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia;Univ New South Wales, Fac Med, Sydney, NSW, Australia4 aut
7001 a Micha, Renatau Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA4 aut
7001 a Forouhi, Nita G.u Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, England4 aut
7001 a Lemaitre, Rozenn N.u Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA4 aut
7001 a Mozaffarian, Dariushu Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA4 aut
7102 a Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, Cambridge, Englandb Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA4 org
7730 t PLoS Medicined : Public Library of Science (PLoS)g 15:10q 15:10x 1549-1277x 1549-1676
8564 u https://doi.org/10.1371/journal.pmed.1002670y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1271431/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002670&type=printable
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369767
8564 8u https://doi.org/10.1371/journal.pmed.1002670

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