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Similar bleeding ph...
Similar bleeding phenotype in young children with haemophilia A or B : A cohort study
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- Clausen, Niels (author)
- Aarhus University Hospital
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- Petrini, P. (author)
- Karolinska University Hospital
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- Claeyssens-Donadel, S. (author)
- Toulouse University Hospital
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- Gouw, S. C. (author)
- Emma Children’s Hospital
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- Liesner, R. (author)
- Great Ormond Street Hospital
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- Altisent, C. (author)
- Vall d'Hebron University Hospital
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- Auerswald, G. (author)
- Klinikum Bremen-Mitte
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- Carcao, M. (author)
- University of Toronto
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- Chalmers, E. (author)
- Royal Hospital for Sick Children, Glasgow
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- Chambost, H. (author)
- Aix-Marseille University
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Cid, A. (author)
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Fischer, K. (author)
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van Geet, Ch (author)
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Peerlinck, K. (author)
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Kenet, G. (author)
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Kobelt, R. (author)
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Kreuz, W. (author)
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Escuriola, C. (author)
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Goethe, J. W. (author)
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Kurnik, K. (author)
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- Ljung, R. (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Paediatric Haematology Research Unit,Lund University Research Groups,Skåne University Hospital
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Mäkipernaa, A. (author)
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Molinari, A. (author)
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Muntean, W. (author)
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Nolan, B. (author)
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Oldenburg, J. (author)
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Pérez Garrido, R. (author)
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Platokouki, H. (author)
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Rafowicz, A. (author)
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Rivard, G. (author)
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Santagostino, E. (author)
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Mancuso, M. E. (author)
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Williams, M. (author)
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van der Bom, J. G. (author)
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van den Berg, H. M. (author)
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(creator_code:org_t)
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- 2014-06-03
- 2014
- English 9 s.
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In: Haemophilia. - : Wiley. - 1351-8216. ; 20:6, s. 747-755
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The bleeding phenotype has been suggested to differ between haemophilia A and B. More knowledge on the bleeding phenotype at initiation of treatment is important to optimize patient care. The aim of this study was to investigate the severity of the bleeding phenotype and the variation in bleeding in children with severe or moderate haemophilia A and B. Consecutive, previously untreated patients with severe or moderate haemophilia A and B (factor VIII or IX activity <0.01 or 0.01-0.05 IU mL-1 respectively) born between January 1st 2000 and January 1st 2010 were included. Primary outcome was severity of bleeding tendency. Secondary outcome was variation in bleeding pattern. A total of 582 patients with severe haemophilia A and 76 with severe haemophilia B did not differ in age at first exposure to clotting factor (0.81 vs. 0.88 years, P = 0.20), age at first bleed (0.82 vs. 0.88 years, P = 0.36), and age at first joint bleed (1.18 vs. 1.20 years, P = 0.59). Patients with moderate haemophilia were older compared to patients with severe haemophilia. In patients with moderate haemophilia there were no clear differences between haemophilia A and B. Severity and variation in bleeding phenotype are similar during the early stage of treatment in patients with severe and moderate haemophilia A and B respectively. The findings imply that children with haemophilia B should be observed and treated as vigilantly as those with haemophilia A.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Bleeding phenotype
- Children
- Haemophilia A
- Haemophilia B
- Haemorrhage
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Clausen, Niels
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Petrini, P.
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Claeyssens-Donad ...
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Gouw, S. C.
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Liesner, R.
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Altisent, C.
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show more...
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Auerswald, G.
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Carcao, M.
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Chalmers, E.
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Chambost, H.
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Cid, A.
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Fischer, K.
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van Geet, Ch
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Peerlinck, K.
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Kenet, G.
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Kobelt, R.
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Kreuz, W.
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Escuriola, C.
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Goethe, J. W.
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Kurnik, K.
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Ljung, R.
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Mäkipernaa, A.
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Molinari, A.
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Muntean, W.
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Nolan, B.
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Oldenburg, J.
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Pérez Garrido, R ...
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Platokouki, H.
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Rafowicz, A.
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Rivard, G.
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Santagostino, E.
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Mancuso, M. E.
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Williams, M.
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van der Bom, J. ...
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van den Berg, H. ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Haemophilia
- By the university
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Lund University