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Laboratory screenin...
Laboratory screening test with inhalant and food allergens in atopic Brazilian children and adolescents : a performance
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- Rozalem Reali, Ana Carolina (author)
- Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
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- Pierotti, Felipe Faria (author)
- Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
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- Aranda, Carolina Sanchez (author)
- Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
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- Cocco, Renata Rodrigues (author)
- Albert Einstein Israeli Fac Hlth Sci, Pediat Dept, Sao Paulo, SP, Brazil.
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- Cavalcanti Sarinho, Emanuel S. (author)
- Univ Fed Pernambuco, Pediat Dept, Recife, PE, Brazil.
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- Sano, Flavio (author)
- Nipo Brazilian Hosp, Pediat Dept, Sao Paulo, SP, Brazil.
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- Porto Neto, Arnaldo (author)
- Fed Univ Fronteira Sul, Pediat Dept, Passo Fundo, RS, Brazil.
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- Rosario, Nelson A. (author)
- Univ Fed Parana, Pediat Dept, Curitiba, Parana, Brazil.
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- Chong Neto, Herberto J. (author)
- Univ Fed Parana, Pediat Dept, Curitiba, Parana, Brazil.
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- Goudouris, Ekaterini Simoes (author)
- Univ Fed Rio de Janeiro, Pediat Dept, Rio De Janeiro, RJ, Brazil.
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- Moraes, Lilian Sanches (author)
- Univ Fed Mato Grosso, Pediat Dept, Cuiaba, Mato Grosso, Brazil.
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- Wandalsen, Neusa Falbo (author)
- ABCs Fdn, Fac Med, Pediat Dept, Santo Andre, SP, Brazil.
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- Pastorino, Antonio Carlos (author)
- Univ Sao Paulo, Pediat Dept, Sao Paulo, SP, Brazil.
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- Franco, Jackeline Motta (author)
- Univ Fed Sergipe, Pediat Dept, Aracaju, Sergipe, Brazil.
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- Chavarria, Maria Leticia (author)
- Univ Fed Goias, Pediat Dept, Goiania, Go, Brazil.
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- Borres, Magnus P, 1956- (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fisher Scientific
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- Sole, Dirceu (author)
- Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil.
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Univ Fed Sao Paulo, Pediat Dept, Escola Paulista Med, Sao Paulo, SP, Brazil Albert Einstein Israeli Fac Hlth Sci, Pediat Dept, Sao Paulo, SP, Brazil. (creator_code:org_t)
- 2021-09-01
- 2021
- English.
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In: Allergologia et Immunopathologia. - : CODON PUBLICATIONS. - 0301-0546 .- 1578-1267. ; 49:5, s. 42-48
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Abstract
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- The Phadiatop Infant (R)) is a panel developed to assess allergic sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines inhalant and food allergens. The test has not been evaluated outside Europe. This is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate PhInf as an allergic disease screening method in Brazilian children. Children as controls and patients (aged 6 months-18 years) were grouped according to their primary disease and age group. PhInf and specific serum IgE (sIgE) screening was performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix of grasses and pollens, eggs, cow's milk, peanuts, and shrimp. Values >= 0.35 kU (A)/L (or PAU/L) were considered positive. A total of 470 children and adolescents, which included 385 patients and 85 controls, participated in the study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had positive PhInf test (n = 341), with a higher proportion of those having food allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity of PhInf test in this population was high and had an excellent correlation with the allergens comprising the panel. It is a useful method for screening children suspected of having allergic diseases in a non-European country.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- child
- hypersensitivity
- immunoglobulin E
- allergens
- Phadiatop infant
Publication and Content Type
- ref (subject category)
- art (subject category)
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Rozalem Reali, A ...
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Pierotti, Felipe ...
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Aranda, Carolina ...
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Cocco, Renata Ro ...
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Cavalcanti Sarin ...
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Sano, Flavio
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Porto Neto, Arna ...
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Rosario, Nelson ...
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Chong Neto, Herb ...
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Goudouris, Ekate ...
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Moraes, Lilian S ...
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Wandalsen, Neusa ...
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Pastorino, Anton ...
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Franco, Jackelin ...
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Chavarria, Maria ...
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Borres, Magnus P ...
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Sole, Dirceu
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Allergologia et ...
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Uppsala University