Sökning: (WFRF:(Cologne J.)) pers:(Fuhrman B. J.) > Steroid hormone mea...
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000 | 05078naa a2200901 4500 | |
001 | oai:lup.lub.lu.se:15b38a34-114a-492a-a053-3c96fffaf2cf | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/77906412 URI |
024 | 7 | a https://doi.org/10.1016/j.steroids.2014.09.0012 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Key, T. J.4 aut |
245 | 1 0 | a Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies |
264 | 1 | b Elsevier BV,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Breast cancer | |
653 | a Estradiol | |
653 | a Body mass index | |
653 | a Extraction immunoassay | |
653 | a Direct immunoassay | |
653 | a Mass spectrometry | |
700 | 1 | a Appleby, P. N.4 aut |
700 | 1 | a Reeves, G. K.4 aut |
700 | 1 | a Travis, R. C.4 aut |
700 | 1 | a Brinton, L. A.4 aut |
700 | 1 | a Dallal, C. M.4 aut |
700 | 1 | a Helzlsouer, K. J.4 aut |
700 | 1 | a Hoffman-Bolton, J.4 aut |
700 | 1 | a Visvanathan, K.4 aut |
700 | 1 | a Dorgan, J. F.4 aut |
700 | 1 | a Falk, R. T.4 aut |
700 | 1 | a Gapstur, S. M.4 aut |
700 | 1 | a Gaudet, M. M.4 aut |
700 | 1 | a Kaaks, R.4 aut |
700 | 1 | a Riboli, E.4 aut |
700 | 1 | a Rinaldi, S.4 aut |
700 | 1 | a Key, T.4 aut |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Hallmans, G.4 aut |
700 | 1 | a Giles, G. G.4 aut |
700 | 1 | a Le Marchand, L.4 aut |
700 | 1 | a Kolonel, L. N.4 aut |
700 | 1 | a Henderson, B. E.4 aut |
700 | 1 | a Tworoger, S. S.4 aut |
700 | 1 | a Hankinson, S. E.4 aut |
700 | 1 | a Zeleniuch-Jacquotte, A.4 aut |
700 | 1 | a Koenig, K.4 aut |
700 | 1 | a Krogh, V.4 aut |
700 | 1 | a Sieri, S.4 aut |
700 | 1 | a Muti, P.4 aut |
700 | 1 | a Ziegler, R. G.4 aut |
700 | 1 | a Schairer, C.4 aut |
700 | 1 | a Fuhrman, B. J.4 aut |
700 | 1 | a Barrett-Connor, E.4 aut |
700 | 1 | a Laughlin, G. A.4 aut |
700 | 1 | a Grant, E. J.4 aut |
700 | 1 | a Cologne, J.4 aut |
700 | 1 | a Ohishi, W.4 aut |
700 | 1 | a Hida, A.4 aut |
700 | 1 | a Cauley, J. A.4 aut |
700 | 1 | a Fourkala, E.-O.4 aut |
700 | 1 | a Rohan, T. E.4 aut |
700 | 1 | a Strickler, H. D.4 aut |
700 | 1 | a Gunter, M. J.4 aut |
710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Steroidsd : Elsevier BVg 99, s. 49-55q 99<49-55x 0039-128X |
856 | 4 | u https://portal.research.lu.se/files/3144987/8725608.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.steroids.2014.09.001x freey FULLTEXT |
856 | 4 | u https://doi.org/10.1016/j.steroids.2014.09.001 |
856 | 4 8 | u https://lup.lub.lu.se/record/7790641 |
856 | 4 8 | u https://doi.org/10.1016/j.steroids.2014.09.001 |
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