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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005078naa a2200901 4500
001oai:lup.lub.lu.se:15b38a34-114a-492a-a053-3c96fffaf2cf
003SwePub
008160401s2015 | |||||||||||000 ||eng|
024a https://lup.lub.lu.se/record/77906412 URI
024a https://doi.org/10.1016/j.steroids.2014.09.0012 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Key, T. J.4 aut
2451 0a Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies
264 1b Elsevier BV,c 2015
338 a electronic2 rdacarrier
520 a Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Breast cancer
653 a Estradiol
653 a Body mass index
653 a Extraction immunoassay
653 a Direct immunoassay
653 a Mass spectrometry
700a Appleby, P. N.4 aut
700a Reeves, G. K.4 aut
700a Travis, R. C.4 aut
700a Brinton, L. A.4 aut
700a Dallal, C. M.4 aut
700a Helzlsouer, K. J.4 aut
700a Hoffman-Bolton, J.4 aut
700a Visvanathan, K.4 aut
700a Dorgan, J. F.4 aut
700a Falk, R. T.4 aut
700a Gapstur, S. M.4 aut
700a Gaudet, M. M.4 aut
700a Kaaks, R.4 aut
700a Riboli, E.4 aut
700a Rinaldi, S.4 aut
700a Key, T.4 aut
700a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700a Hallmans, G.4 aut
700a Giles, G. G.4 aut
700a Le Marchand, L.4 aut
700a Kolonel, L. N.4 aut
700a Henderson, B. E.4 aut
700a Tworoger, S. S.4 aut
700a Hankinson, S. E.4 aut
700a Zeleniuch-Jacquotte, A.4 aut
700a Koenig, K.4 aut
700a Krogh, V.4 aut
700a Sieri, S.4 aut
700a Muti, P.4 aut
700a Ziegler, R. G.4 aut
700a Schairer, C.4 aut
700a Fuhrman, B. J.4 aut
700a Barrett-Connor, E.4 aut
700a Laughlin, G. A.4 aut
700a Grant, E. J.4 aut
700a Cologne, J.4 aut
700a Ohishi, W.4 aut
700a Hida, A.4 aut
700a Cauley, J. A.4 aut
700a Fourkala, E.-O.4 aut
700a Rohan, T. E.4 aut
700a Strickler, H. D.4 aut
700a Gunter, M. J.4 aut
710a Kirurgib Forskargrupper vid Lunds universitet4 org
773t Steroidsd : Elsevier BVg 99, s. 49-55q 99<49-55x 0039-128X
856u https://portal.research.lu.se/files/3144987/8725608.pdfx primaryx freey FULLTEXT
856u http://dx.doi.org/10.1016/j.steroids.2014.09.001x freey FULLTEXT
856u https://doi.org/10.1016/j.steroids.2014.09.001
8564 8u https://lup.lub.lu.se/record/7790641
8564 8u https://doi.org/10.1016/j.steroids.2014.09.001

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