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Sökning: (WFRF:(D'Alessandro Umberto)) > (2017) > Haemoglobin changes...

  • Zwang, Julien (författare)

Haemoglobin changes and risk of anaemia following treatment for uncomplicated falciparum malaria in sub-Saharan Africa

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-06-23
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-359806
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359806URI
  • https://doi.org/10.1186/s12879-017-2530-6DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136112007URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Anaemia is common in malaria. It is important to quantitate the risk of anaemia and to distinguish factors related to the natural history of disease from potential drug toxicity. Methods: Individual-patient data analysis based on nine randomized controlled trials of treatments of uncomplicated falciparum malaria from 13 sub-Saharan African countries. Risk factors for reduced haemoglobin (Hb) concentrations and anaemia on presentation and after treatment were analysed using mixed effect models. Results: Eight thousand eight hundred ninety-seven patients (77.0% < 5 years-old) followed-up through 28 days treated with artemisinin combination therapy (ACT, 90%, n = 7968) or non-ACT. At baseline, under 5' s had the highest risk of anaemia (77.6% vs. 32.8%) and higher parasitaemia (43,938 mu l) than older subjects (2784 mu l). Baseline anaemia increased the risk of parasitological recurrence. Hb began to fall after treatment start. In under 5' s the estimated nadir was similar to 35 h (range 29-48), with a drop of -12.8% from baseline (from 9.8 g/dl to 8.7 g/dl, p = 0.001); in under 15's, the mean Hb decline between day 0-3 was -4.7% (from 9.4 to 9.0 g/dl, p = 0.001). The degree of Hb loss was greater in patients with high pre-treatment Hb and parasitaemia and with slower parasite reduction rates, and was unrelated to age. Subsequently, Hb increased linearly (+0.6%/day) until day 28, to reach + 13.8% compared to baseline. Severe anaemia (< 5 g/dl, 2 per 1000 patients) was transient and all patients recovered after day 14, except one case of very severe anaemia associated with parasite recurrence at day 28. There was no systematic difference in Hb concentrations between treatments and no case of delayed anaemia. Conclusion: On presentation with acute malaria young children with high parasitaemia have the highest risk of anaemia. The majority of patients experience a drop in Hb while on treatment as early as day 1-2, followed by a linear increase through follow-up. The degree of the early Hb dip is determined by pre-treatment parasitaemia and parasite clearance rates. Hb trends and rick of anaemia are independent of treatment.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • D'Alessandro, UmbertoMRC Unit, Banjul, Gambia;London Sch Hyg & Trop Med, London, England;Inst Trop Med, Antwerp, Belgium (författare)
  • Ndiaye, Jean-LouisCheikh Anta Diop Univ, Dept Parasitol, Fac Med, Dakar, Senegal (författare)
  • Djimde, Abdoulaye A.Univ Sci Tech & Technol Bamako, Fac Pharm, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali (författare)
  • Dorsey, GrantUniv Calif San Francisco, Dept Med, San Francisco, CA USA (författare)
  • Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition,Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden(Swepub:uu)andma331 (författare)
  • Karema, CorineSwiss Trop & Publ Hlth Inst, Basel, Switzerland;Univ Basel, Basel, Switzerland (författare)
  • Olliaro, Piero L.Special Programme Res & Training Trop Dis WHO TDR, 20 Ave Appia, CH-1211 Geneva, Switzerland;Univ Oxford, Churchill Hosp, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford OX3 7LJ, England;Univ Basel, Basel, Switzerland (författare)
  • MRC Unit, Banjul, Gambia;London Sch Hyg & Trop Med, London, England;Inst Trop Med, Antwerp, BelgiumCheikh Anta Diop Univ, Dept Parasitol, Fac Med, Dakar, Senegal (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Infectious Diseases: Springer Science and Business Media LLC171471-2334

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