Search: (WFRF:(D'Amato Mauro)) pers:(Silverberg Mark S) pers:(Parkes Miles)
> (2010) >
Genome-wide meta-an...
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- Article/chapterEnglish2010
Publisher, publication year, extent ...
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2010-11-21
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Springer Science and Business Media LLC,2010
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-27404
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27404URI
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https://doi.org/10.1038/ng.717DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:121622686URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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McGovern, Dermot P B
(author)
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Barrett, Jeffrey C
(author)
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Wang, Kai
(author)
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Radford-Smith, Graham L
(author)
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Ahmad, Tariq
(author)
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Lees, Charlie W
(author)
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Balschun, Tobias
(author)
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Lee, James
(author)
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Roberts, Rebecca
(author)
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Anderson, Carl A
(author)
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Bis, Joshua C
(author)
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Bumpstead, Suzanne
(author)
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Ellinghaus, David
(author)
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Festen, Eleonora M
(author)
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Georges, Michel
(author)
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Green, Todd
(author)
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Haritunians, Talin
(author)
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Jostins, Luke
(author)
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Latiano, Anna
(author)
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Mathew, Christopher G
(author)
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Montgomery, Grant W
(author)
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Prescott, Natalie J
(author)
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Raychaudhuri, Soumya
(author)
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Rotter, Jerome I
(author)
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Schumm, Philip
(author)
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Sharma, Yashoda
(author)
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Simms, Lisa A
(author)
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Taylor, Kent D
(author)
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Whiteman, David
(author)
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Wijmenga, Cisca
(author)
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Baldassano, Robert N
(author)
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Barclay, Murray
(author)
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Bayless, Theodore M
(author)
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Brand, Stephan
(author)
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Büning, Carsten
(author)
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Cohen, Albert
(author)
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Colombel, Jean-Frederick
(author)
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Cottone, Mario
(author)
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Stronati, Laura
(author)
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Denson, Ted
(author)
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De Vos, Martine
(author)
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D'Inca, Renata
(author)
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Dubinsky, MarlaKarolinska Institutet
(author)
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Edwards, Cathryn
(author)
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Florin, Tim
(author)
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Franchimont, Denis
(author)
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Gearry, Richard
(author)
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Glas, Jürgen
(author)
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Van Gossum, Andre
(author)
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Guthery, Stephen L
(author)
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Halfvarson, Jonas,1970-Örebro universitet,Hälsoakademin(Swepub:oru)jshn
(author)
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Verspaget, Hein W
(author)
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Hugot, Jean-Pierre
(author)
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Karban, Amir
(author)
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Laukens, Debby
(author)
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Lawrance, Ian
(author)
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Lemann, Marc
(author)
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Levine, Arie
(author)
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Libioulle, Cecile
(author)
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Louis, Edouard
(author)
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Mowat, Craig
(author)
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Newman, William
(author)
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Panés, Julián
(author)
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Phillips, Anne
(author)
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Proctor, Deborah D
(author)
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Regueiro, Miguel
(author)
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Russell, Richard
(author)
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Rutgeerts, Paul
(author)
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Sanderson, Jeremy
(author)
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Sans, Miquel
(author)
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Seibold, Frank
(author)
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Steinhart, A Hillary
(author)
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Stokkers, Pieter C F
(author)
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Torkvist, LeifKarolinska Institutet
(author)
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Kullak-Ublick, Gerd
(author)
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Wilson, David
(author)
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Walters, Thomas
(author)
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Targan, Stephan R
(author)
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Brant, Steven R
(author)
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Rioux, John D
(author)
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D'Amato, Mauro
(author)
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Weersma, Rinse K
(author)
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Kugathasan, Subra
(author)
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Griffiths, Anne M
(author)
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Mansfield, John C
(author)
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Vermeire, Severine
(author)
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Duerr, Richard H
(author)
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Silverberg, Mark S
(author)
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Satsangi, Jack
(author)
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Schreiber, Stefan
(author)
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Cho, Judy H
(author)
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Annese, Vito
(author)
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Hakonarson, Hakon
(author)
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Daly, Mark J
(author)
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Parkes, Miles
(author)
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Karolinska InstitutetHälsoakademin
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC42:12, s. 1118-11251061-40361546-1718
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Franke, Andre
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McGovern, Dermot ...
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Barrett, Jeffrey ...
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Wang, Kai
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Radford-Smith, G ...
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Ahmad, Tariq
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Lees, Charlie W
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Lee, James
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Mathew, Christop ...
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Montgomery, Gran ...
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Dubinsky, Marla
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Nature Genetics
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Örebro University
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Karolinska Institutet