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Using nanofluidic c...
Using nanofluidic channels to probe dynamics of RAD51-Filaments
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- Fornander, Louise, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Alizadehheidari, Mohammadreza, 1987 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Werner, E. (author)
- Göteborgs universitet,University of Gothenburg
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- Çekir, A. (author)
- Göteborgs universitet,University of Gothenburg
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- Fritzsche, Joachim, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Araya, J. (author)
- Northeastern University
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- Nevin, P. (author)
- Northeastern University
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- Beuning, P. J. (author)
- Northeastern University
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- Mehlig, Bernhard, 1964 (author)
- Göteborgs universitet,University of Gothenburg
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- Modesti, M. (author)
- Aix-Marseille Université,Aix Marseille University
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- Frykholm, Karolin, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Persson, F. (author)
- Uppsala universitet,Uppsala University
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- Westerlund, Fredrik, 1978 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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(creator_code:org_t)
- ISBN 9780979806476
- 2015
- 2015
- English.
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In: 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. - 9780979806476 ; , s. 1826-1828
- Related links:
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https://research.cha...
Abstract
Subject headings
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- Using nanochannels, passivated with a lipid bilayer to avoid sticking of proteins, we study Rad51 filaments bound to single- and double stranded DNA. We demonstrate how we can discern different properties of the filaments by studying them at different degrees of confinement. Unlike the bacterial homologue RecA, that forms homogeneous filaments along DNA, Rad51 forms heterogeneous filaments containing both rigid kinks as well as flexible regions. Varying the counterion, the DNA substrate as well as the initial protein concentration, we try to understand the factors governing the structure of the filaments.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- DNA-protein interactions
- Lipid passivation
- Nanofluidics
- Rad51
Publication and Content Type
- kon (subject category)
- ref (subject category)
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Fornander, Louis ...
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Alizadehheidari, ...
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Werner, E.
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Çekir, A.
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Fritzsche, Joach ...
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Araya, J.
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show more...
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Nevin, P.
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Beuning, P. J.
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Mehlig, Bernhard ...
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Modesti, M.
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Frykholm, Karoli ...
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Persson, F.
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Westerlund, Fred ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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18th Internation ...
- By the university
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Chalmers University of Technology