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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003924naa a2200493 4500
001oai:DiVA.org:uu-246348
003SwePub
008150305s2015 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2463482 URI
0247 a https://doi.org/10.1002/ccd.255452 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bourantas, Christos V.4 aut
2451 0a Prognostic Implications of Severe Coronary Calcification in Patients Undergoing Coronary Artery Bypass Surgery :b An Analysis of the SYNTAX Study
264 c 2014-05-27
264 1b Wiley,c 2015
338 a print2 rdacarrier
520 a ObjectivesTo investigate the prognostic implications of the presence of severe lesion calcification in patients undergoing coronary artery bypass graft (CABG) operation. BackgroundThere is robust evidence that lesion calcification is a predictor of worse prognosis in patients undergoing percutaneous coronary intervention; however, there is limited data about the prognostic implication of lesion calcium in patients treated with CABG. MethodsWe retrospectively analyzed data from 1,545 patients who underwent CABG and were recruited in the SYNTAX study and CABG registry. Two experts reviewed the angiographic data and classified patients in two groups: those with severely calcified coronary arteries and those without severe lesion calcification. Clinical outcomes at 5-year follow-up were collected and compared in the two groups. ResultsOne out of three patients exhibited severe lesion calcification (n=588). Patients with calcified coronaries had an increased mortality at 5-year follow-up (17.1% vs. 9.9%, P<0.001) and a higher event rate of death-myocardial infarction (MI) compared with those without (19.4% vs. 13.2%, P=0.003), but there was no statistical significant difference between the two groups for major adverse cardiovascular events (MACE, 26.8% vs. 21.8%, P=0.057). In multivariate Cox regression analysis severe lesion calcification was an independent predictor of an increased all-cause mortality (hazard ratio: 1.39, 95% confidence interval: 1.02-1.89; P=0.037) but it was not an independent predictor of the combined end-points death-MI or MACE. ConclusionsSevere lesion calcification is associated with an increased mortality in patients undergoing CABG, but it is not an independent predictor of death-MI or MACE. This paradox can be attributed to the fact that CABG allows perfusion of the healthy coronaries bypassing the diseased arteries and thus it minimizes the risk of coronary events due to progressive atherosclerosis. (c) 2014 Wiley Periodicals, Inc.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a clinical outcomes
653 a revascularization
653 a coronary artery disease
7001 a Zhang, Yao-Jun4 aut
7001 a Garg, Scot4 aut
7001 a Mack, Michael4 aut
7001 a Dawkins, Keith D.4 aut
7001 a Kappetein, Arie Pieter4 aut
7001 a Mohr, Friedrich W.4 aut
7001 a Colombo, Antonio4 aut
7001 a Holmes, David R.4 aut
7001 a Ståhle, Elisabethu Uppsala universitet,Thoraxkirurgi4 aut0 (Swepub:uu)elsta102
7001 a Feldman, Ted4 aut
7001 a Morice, Marie-Claude4 aut
7001 a de Vries, Ton4 aut
7001 a Morel, Marie-Angele4 aut
7001 a Serruys, Patrick W.4 aut
7102 a Uppsala universitetb Thoraxkirurgi4 org
7730 t Catheterization and cardiovascular interventionsd : Wileyg 85:2, s. 199-206q 85:2<199-206x 1522-1946x 1522-726X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246348
8564 8u https://doi.org/10.1002/ccd.25545

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