(WFRF:(Goodall Alison H.)) pers:(Uitterlinden Andre G.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 26844naa a2206577 4500 | |
| 001 | oai:lup.lub.lu.se:d86b0162-3e09-4c95-b2a6-dc3f755cdec8 | |
| 003 | SwePub | |
| 008 | 160401s2015 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-100949 | |
| 009 | oai:prod.swepub.kib.ki.se:130690386 | |
| 009 | oai:DiVA.org:uu-244272 | |
| 009 | oai:gup.ub.gu.se/213541 | |
| 009 | oai:DiVA.org:du-21320 | |
| 024 | 7 | a https://lup.lub.lu.se/record/51439232 URI |
| 024 | 7 | a https://doi.org/10.1038/nature141772 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1009492 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306903862 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2442722 URI |
| 024 | 7 | a https://gup.ub.gu.se/publication/2135412 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-213202 URI |
| 040 | a (SwePub)lud (SwePub)umud (SwePub)kid (SwePub)uud (SwePub)gud (SwePub)du | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Locke, Adam E4 aut |
| 245 | 1 0 | a Genetic studies of body mass index yield new insights for obesity biology. |
| 264 | c 2015-02-11 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2015 |
| 500 | a De fem sista författarna delar sistaförfattarskapet. | |
| 520 | a Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Polymorphism | |
| 653 | a Obesity: metabolism | |
| 653 | a Obesity: genetics | |
| 653 | a Insulin: secretion | |
| 653 | a Insulin: metabolism | |
| 653 | a Glutamic Acid: metabolism | |
| 653 | a Genetic Predisposition to Disease: genetics | |
| 653 | a Europe: ethnology | |
| 653 | a Energy Metabolism: genetics | |
| 653 | a Continental Population Groups: genetics | |
| 653 | a Adipogenesis: genetics | |
| 653 | a Adiposity: genetics | |
| 653 | a Single Nucleotide: genetics | |
| 653 | a Quantitative Trait Loci: genetics | |
| 653 | a Synapses: metabolism | |
| 653 | a body mass; copy number variation; disease course; energy metabolism; gene expression; gene frequency; gene linkage disequilibrium; genetic association; genetic variability; heredity; human; insulin release; nonhuman; obesity; phenotype; priority journal; quantitative trait locus; receiver operating characteristic | |
| 653 | a Hälsa och välfärd | |
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| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Yang, Jian4 aut |
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| 700 | 1 | a Fall, Toveu Uppsala universitet,Karolinska Institutet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)tovfa878 |
| 700 | 1 | a Ferreira, Teresa4 aut |
| 700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
| 700 | 1 | a Kutalik, Zoltán4 aut |
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| 700 | 1 | a Kristiansson, Katiu Karolinska Institutet4 aut |
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| 700 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003 |
| 700 | 1 | a Stančáková, Alena4 aut |
| 700 | 1 | a Strawbridge, Rona Ju Karolinska Institutet4 aut |
| 700 | 1 | a Ju Sung, Yun4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
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| 700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
| 700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
| 700 | 1 | a Go, Alan S4 aut |
| 700 | 1 | a Golay, Alain4 aut |
| 700 | 1 | a Goodall, Alison Hu Karolinska Institutet4 aut |
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| 700 | 1 | a Gorski, Mathias4 aut |
| 700 | 1 | a Grabe, Hans-Jörgen4 aut |
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| 700 | 1 | a Gräßler, Jürgen4 aut |
| 700 | 1 | a Grönberg, Henriku Karolinska Institutet4 aut |
| 700 | 1 | a Groves, Christopher J4 aut |
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| 700 | 1 | a Haessler, Jeffrey4 aut |
| 700 | 1 | a Hall, Per4 aut |
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| 700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001 |
| 700 | 1 | a Hartman, Catharina A4 aut |
| 700 | 1 | a Hassinen, Maija4 aut |
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| 700 | 1 | a Johansson, Åsau Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)asjoh108 |
| 700 | 1 | a Jolley, Jenniferu Karolinska Institutet4 aut |
| 700 | 1 | a Juliusdottir, Thorhildur4 aut |
| 700 | 1 | a Kinnunen, Leena4 aut |
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| 700 | 1 | a Lind, Larsu Karolinska Institutet4 aut |
| 700 | 1 | a Lindström, Jaana4 aut |
| 700 | 1 | a Sin Lo, Ken4 aut |
| 700 | 1 | a Lobbens, Stéphane4 aut |
| 700 | 1 | a Lorbeer, Roberto4 aut |
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| 700 | 1 | a Mach, François4 aut |
| 700 | 1 | a Magnusson, Patrik K Eu Karolinska Institutet4 aut |
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| 700 | 1 | a McLachlan, Stela4 aut |
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| 700 | 1 | a Renström, Fridau Umeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:lu)med-frm |
| 700 | 1 | a Rettig, Rainer4 aut |
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| 700 | 1 | a Ripke, Stephan4 aut |
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| 700 | 1 | a Steinthorsdottir, Valgerdur4 aut |
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| 700 | 1 | a Sundström, Johanu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)johasund |
| 700 | 1 | a Swertz, Morris A4 aut |
| 700 | 1 | a Swift, Amy J4 aut |
| 700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva |
| 700 | 1 | a Tan, Sian-Tsung4 aut |
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| 700 | 1 | a Vandenput, Liesbeth,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xvanli |
| 700 | 1 | a Verhulst, Frank C4 aut |
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| 700 | 1 | a Vonk, Judith M4 aut |
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| 700 | 1 | a Goddard, Michael E4 aut |
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| 700 | 1 | a Erdmann, Jeanette4 aut |
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| 700 | 1 | a Ford, Ian4 aut |
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| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Hall, Alistair S4 aut |
| 700 | 1 | a Harris, Tamara B4 aut |
| 700 | 1 | a Hattersley, Andrew T4 aut |
| 700 | 1 | a Hicks, Andrew A4 aut |
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| 700 | 1 | a Hofman, Albert4 aut |
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| 700 | 1 | a Hovingh, G Kees4 aut |
| 700 | 1 | a Humphries, Steve E4 aut |
| 700 | 1 | a Hunt, Steven C4 aut |
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| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Jacobs, Kevin B4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Jöckel, Karl-Heinz4 aut |
| 700 | 1 | a Johansen, Berit4 aut |
| 700 | 1 | a Jousilahti, Pekka4 aut |
| 700 | 1 | a Jukema, J Wouter4 aut |
| 700 | 1 | a Jula, Antti M4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Kastelein, John J P4 aut |
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| 700 | 1 | a Knekt, Paul4 aut |
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| 700 | 1 | a Kovacs, Peter4 aut |
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| 700 | 1 | a Lehtimäki, Terho4 aut |
| 700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
| 700 | 1 | a Männistö, Satu4 aut |
| 700 | 1 | a Marette, André4 aut |
| 700 | 1 | a Matise, Tara C4 aut |
| 700 | 1 | a McKenzie, Colin A4 aut |
| 700 | 1 | a McKnight, Barbara4 aut |
| 700 | 1 | a Moll, Frans L4 aut |
| 700 | 1 | a Morris, Andrew D4 aut |
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| 700 | 1 | a Murray, Jeffrey C4 aut |
| 700 | 1 | a Nelis, Mari4 aut |
| 700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
| 700 | 1 | a Oldehinkel, Albertine J4 aut |
| 700 | 1 | a Ong, Ken K4 aut |
| 700 | 1 | a Madden, Pamela A F4 aut |
| 700 | 1 | a Pasterkamp, Gerard4 aut |
| 700 | 1 | a Peden, John F4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Postma, Dirkje S4 aut |
| 700 | 1 | a Pramstaller, Peter P4 aut |
| 700 | 1 | a Price, Jackie F4 aut |
| 700 | 1 | a Qi, Lu4 aut |
| 700 | 1 | a Raitakari, Olli T4 aut |
| 700 | 1 | a Rankinen, Tuomo4 aut |
| 700 | 1 | a Rao, D C4 aut |
| 700 | 1 | a Rice, Treva K4 aut |
| 700 | 1 | a Ridker, Paul M4 aut |
| 700 | 1 | a Rioux, John D4 aut |
| 700 | 1 | a Ritchie, Marylyn D4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Samani, Nilesh J4 aut |
| 700 | 1 | a Saramies, Jouko4 aut |
| 700 | 1 | a Sarzynski, Mark A4 aut |
| 700 | 1 | a Schunkert, Heribert4 aut |
| 700 | 1 | a Schwarz, Peter E H4 aut |
| 700 | 1 | a Sever, Peter4 aut |
| 700 | 1 | a Shuldiner, Alan R4 aut |
| 700 | 1 | a Sinisalo, Juha4 aut |
| 700 | 1 | a Stolk, Ronald P4 aut |
| 700 | 1 | a Strauch, Konstantin4 aut |
| 700 | 1 | a Tönjes, Anke4 aut |
| 700 | 1 | a Trégouët, David-Alexandre4 aut |
| 700 | 1 | a Tremblay, Angelo4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a Virtamo, Jarmo4 aut |
| 700 | 1 | a Vohl, Marie-Claude4 aut |
| 700 | 1 | a Völker, Uwe4 aut |
| 700 | 1 | a Waeber, Gérard4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Witteman, Jacqueline C4 aut |
| 700 | 1 | a Zillikens, M Carola4 aut |
| 700 | 1 | a Adair, Linda S4 aut |
| 700 | 1 | a Amouyel, Philippe4 aut |
| 700 | 1 | a Asselbergs, Folkert W4 aut |
| 700 | 1 | a Assimes, Themistocles L4 aut |
| 700 | 1 | a Bochud, Murielle4 aut |
| 700 | 1 | a Boehm, Bernhard O4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Bornstein, Stefan R4 aut |
| 700 | 1 | a Bottinger, Erwin P4 aut |
| 700 | 1 | a Bouchard, Claude4 aut |
| 700 | 1 | a Cauchi, Stéphane4 aut |
| 700 | 1 | a Chambers, John C4 aut |
| 700 | 1 | a Chanock, Stephen J4 aut |
| 700 | 1 | a Cooper, Richard S4 aut |
| 700 | 1 | a de Bakker, Paul I W4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin4 aut0 (Swepub:umu)pafr0003 |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Haiman, Christopher A4 aut |
| 700 | 1 | a Hamsten, Anders4 aut |
| 700 | 1 | a Hui, Jennie4 aut |
| 700 | 1 | a Hunter, David J4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Kaplan, Robert C4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Martin, Nicholas G4 aut |
| 700 | 1 | a März, Winfried4 aut |
| 700 | 1 | a Melbye, Mads4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Moebus, Susanne4 aut |
| 700 | 1 | a Munroe, Patricia B4 aut |
| 700 | 1 | a Njølstad, Inger4 aut |
| 700 | 1 | a Oostra, Ben A4 aut |
| 700 | 1 | a Palmer, Colin N A4 aut |
| 700 | 1 | a Pedersen, Nancy L4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Pérusse, Louis4 aut |
| 700 | 1 | a Peters, Ulrike4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Quertermous, Thomas4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Saaristo, Timo E4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Sattar, Naveed4 aut |
| 700 | 1 | a Schadt, Eric E4 aut |
| 700 | 1 | a Schlessinger, David4 aut |
| 700 | 1 | a Slagboom, P Eline4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Spector, Tim D4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Stumvoll, Michael4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uitterlinden, André G4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a van der Harst, Pim4 aut |
| 700 | 1 | a Walker, Mark4 aut |
| 700 | 1 | a Wallaschofski, Henri4 aut |
| 700 | 1 | a Wareham, Nicholas J4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Weir, David R4 aut |
| 700 | 1 | a Wichmann, H-Erich4 aut |
| 700 | 1 | a Wilson, James F4 aut |
| 700 | 1 | a Zanen, Pieter4 aut |
| 700 | 1 | a Borecki, Ingrid B4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Fox, Caroline S4 aut |
| 700 | 1 | a Heid, Iris M4 aut |
| 700 | 1 | a O'Connell, Jeffrey R4 aut |
| 700 | 1 | a Strachan, David P4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a van Duijn, Cornelia M4 aut |
| 700 | 1 | a Abecasis, Gonçalo R4 aut |
| 700 | 1 | a Franke, Lude4 aut |
| 700 | 1 | a Frayling, Timothy M4 aut |
| 700 | 1 | a McCarthy, Mark I4 aut |
| 700 | 1 | a Visscher, Peter M4 aut |
| 700 | 1 | a Scherag, André4 aut |
| 700 | 1 | a Willer, Cristen J4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Mohlke, Karen L4 aut |
| 700 | 1 | a Lindgren, Cecilia M4 aut |
| 700 | 1 | a Beckmann, Jacques S4 aut |
| 700 | 1 | a Barroso, Inês4 aut |
| 700 | 1 | a North, Kari E4 aut |
| 700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Hirschhorn, Joel N4 aut |
| 700 | 1 | a Loos, Ruth J F4 aut |
| 700 | 1 | a Speliotes, Elizabeth K4 aut |
| 700 | 1 | a Graessler, Jurgen4 aut |
| 710 | 2 | a Karolinska Institutetb Kardiovaskulär epidemiologi4 org |
| 773 | 0 | t Natured : Springer Science and Business Media LLCg 518:7538, s. 197-401q 518:7538<197-401x 0028-0836x 1476-4687 |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25673413?dopt=Abstracty FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1038/nature14177y FULLTEXT |
| 856 | 4 | u https://europepmc.org/articles/pmc4382211?pdf=render |
| 856 | 4 | u https://du.diva-portal.org/smash/get/diva2:916691/FULLTEXT01.pdfx primaryx Raw objecty fulltext:preprint |
| 856 | 4 8 | u https://lup.lub.lu.se/record/5143923 |
| 856 | 4 8 | u https://doi.org/10.1038/nature14177 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-100949 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:130690386 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244272 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/213541 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-21320 |
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