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Plasma metabolites ...
Plasma metabolites associated with biomarker evidence of neurodegeneration in cognitively normal older adults
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Chatterjee, P. (author)
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Cheong, Y. J. (author)
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Bhatnagar, A. (author)
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Goozee, K. (author)
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Wu, Y. Q. (author)
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McKay, M. (author)
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Martins, I. J. (author)
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Lim, W. L. F. (author)
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Pedrini, S. (author)
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Tegg, M. (author)
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Villemagne, V. L. (author)
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Asih, P. R. (author)
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Dave, P. (author)
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Shah, T. M. (author)
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Dias, C. B. (author)
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Fuller, S. J. (author)
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Hillebrandt, H. (author)
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Gupta, S. (author)
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Hone, E. (author)
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Taddei, K. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Sohrabi, H. R. (author)
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Martins, R. N. (author)
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(creator_code:org_t)
- 2020-08
- 2021
- English.
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In: Journal of Neurochemistry. - : Wiley. - 0022-3042 .- 1471-4159. ; 159:2, s. 389-402
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https://doi.org/10.1...
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Abstract
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- Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no cure. Identifying biochemical changes associated with neurodegeneration prior to symptom onset, will provide insight into the biological mechanisms associated with neurodegenerative processes, that may also aid in identifying potential drug targets. The current study therefore investigated associations between plasma neurofilament light chain (NF-L), a marker of neurodegeneration, with plasma metabolites that are products of various cellular processes. Plasma NF-L, measured by ultrasensitive Single molecule array (Simoa) technology (Quanterix) and plasma metabolites, measured by mass-spectrometry (AbsoluteIDQ (R) p400HR kit, BIOCRATES), were assessed in the Kerr Anglican Retirement Village Initiative in Ageing Health (KARVIAH) cohort comprising 100 cognitively normal older adults. Metabolites belonging to biogenic amine (creatinine, symmetric dimethylarginine, asymmetric dimethylarginine; ADMA, kynurenine, trans-4-hydroxyproline), amino acid (citrulline, proline, arginine, asparagine, phenylalanine, threonine) and acylcarnitine classes were observed to have positive correlations with plasma NF-L, suggesting a link between neurodegeneration and biological pathways associated with neurotransmitter regulation, nitric oxide homoeostasis, inflammation and mitochondrial function. Additionally, after stratifying participants based on low/high brain amyloid-beta load (A beta +/-) assessed by positron emission tomography, while creatinine, SDMA and citrulline correlated with NF-L in both A beta- and A beta+ groups, ADMA, proline, arginine, asparagine, phenylalanine and acylcarnitine species correlated with NF-L only in the A beta+ group after adjusting for confounding variables, suggesting that the association of these metabolites with neurodegeneration may be relevant to AD-related neuropathology. Metabolites identified to be associated with plasma NF-L may have the potential to serve as prognostic markers for neurodegenerative diseases, however, further studies are required to validate the current findings in an independent cohort, both cross-sectionally and longitudinally.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- biomarkers
- metabolomics
- neurodegeneration
- neurofilament light
- preclinical Alzheimer's disease
- acetyl-l-carnitine
- serum neurofilament light
- chronic kidney-disease
- alzheimers-disease
- cerebrospinal-fluid
- nitric-oxide
- symmetric
- dimethylarginine
- differential-diagnosis
- energy-metabolism
- renal-function
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Chatterjee, P.
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Cheong, Y. J.
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Bhatnagar, A.
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Goozee, K.
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Wu, Y. Q.
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McKay, M.
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show more...
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Martins, I. J.
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Lim, W. L. F.
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Pedrini, S.
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Tegg, M.
-
Villemagne, V. L ...
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Asih, P. R.
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Dave, P.
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Shah, T. M.
-
Dias, C. B.
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Fuller, S. J.
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Hillebrandt, H.
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Gupta, S.
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Hone, E.
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Taddei, K.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Sohrabi, H. R.
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Martins, R. N.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Journal of Neuro ...
- By the university
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University of Gothenburg