Sökning: (WFRF:(Hallmans Göran)) pers:(Mangino Massimo) > (2011) > Physical activity a...
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000 | 10072naa a2201825 4500 | |
001 | oai:gup.ub.gu.se/152191 | |
003 | SwePub | |
008 | 240528s2011 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:c38f2e29-1e58-4f8a-958b-3444b1ecb511 | |
009 | oai:DiVA.org:umu-51101 | |
009 | oai:prod.swepub.kib.ki.se:123902905 | |
024 | 7 | a https://gup.ub.gu.se/publication/1521912 URI |
024 | 7 | a https://doi.org/10.1371/journal.pmed.10011162 DOI |
024 | 7 | a https://lup.lub.lu.se/record/23481742 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-511012 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1239029052 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)umud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Kilpeläinen, Tuomas O4 aut |
245 | 1 0 | a Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. |
264 | c 2011-11-01 | |
264 | 1 | b Public Library of Science (PLoS),c 2011 |
520 | a BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) =0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio =1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio =1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
700 | 1 | a Qi, Lu4 aut |
700 | 1 | a Brage, Soren4 aut |
700 | 1 | a Sharp, Stephen J4 aut |
700 | 1 | a Sonestedt, Emilyu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine4 aut0 (Swepub:lu)medf-eso |
700 | 1 | a Demerath, Ellen4 aut |
700 | 1 | a Ahmad, Tariq4 aut |
700 | 1 | a Mora, Samia4 aut |
700 | 1 | a Kaakinen, Marika4 aut |
700 | 1 | a Sandholt, Camilla Helene4 aut |
700 | 1 | a Holzapfel, Christina4 aut |
700 | 1 | a Autenrieth, Christine S4 aut |
700 | 1 | a Hyppönen, Elina4 aut |
700 | 1 | a Cauchi, Stéphane4 aut |
700 | 1 | a He, Meian4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Kumari, Meena4 aut |
700 | 1 | a Stančáková, Alena4 aut |
700 | 1 | a Meidtner, Karina4 aut |
700 | 1 | a Balkau, Beverley4 aut |
700 | 1 | a Tan, Jonathan T4 aut |
700 | 1 | a Mangino, Massimo4 aut |
700 | 1 | a Timpson, Nicholas J4 aut |
700 | 1 | a Song, Yiqing4 aut |
700 | 1 | a Zillikens, M Carola4 aut |
700 | 1 | a Jablonski, Kathleen A4 aut |
700 | 1 | a Garcia, Melissa E4 aut |
700 | 1 | a Johansson, Stefan4 aut |
700 | 1 | a Bragg-Gresham, Jennifer L4 aut |
700 | 1 | a Wu, Ying4 aut |
700 | 1 | a van Vliet-Ostaptchouk, Jana V4 aut |
700 | 1 | a Onland-Moret, N Charlotte4 aut |
700 | 1 | a Zimmermann, Esther4 aut |
700 | 1 | a Rivera, Natalia V4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Stringham, Heather M4 aut |
700 | 1 | a Silbernagel, Günther4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Feitosa, Mary F4 aut |
700 | 1 | a Snitker, Soren4 aut |
700 | 1 | a Ruiz, Jonatan Ru Karolinska Institutet4 aut |
700 | 1 | a Metter, Jeffery4 aut |
700 | 1 | a Larrad, Maria Teresa Martinez4 aut |
700 | 1 | a Atalay, Mustafa4 aut |
700 | 1 | a Hakanen, Maarit4 aut |
700 | 1 | a Amin, Najaf4 aut |
700 | 1 | a Cavalcanti-Proença, Christine4 aut |
700 | 1 | a Grøntved, Anders4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Jansson, John-Olov,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xjanjo |
700 | 1 | a Kuusisto, Johanna4 aut |
700 | 1 | a Kähönen, Mika4 aut |
700 | 1 | a Lutsey, Pamela L4 aut |
700 | 1 | a Nolan, John J4 aut |
700 | 1 | a Palla, Luigi4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Pérusse, Louis4 aut |
700 | 1 | a Renström, Fridau Umeå universitet,Medicin4 aut0 (Swepub:umu)frre0001 |
700 | 1 | a Scott, Robert A4 aut |
700 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)dmsh0003 |
700 | 1 | a Sovio, Ulla4 aut |
700 | 1 | a Tammelin, Tuija H4 aut |
700 | 1 | a Rönnemaa, Tapani4 aut |
700 | 1 | a Lakka, Timo A4 aut |
700 | 1 | a Uusitupa, Matti4 aut |
700 | 1 | a Rios, Manuel Serrano4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Bouchard, Claude4 aut |
700 | 1 | a Meirhaeghe, Aline4 aut |
700 | 1 | a Fu, Mao4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Borecki, Ingrid B4 aut |
700 | 1 | a Dedoussis, George V4 aut |
700 | 1 | a Fritsche, Andreas4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Bandinelli, Stefania4 aut |
700 | 1 | a van Duijn, Cornelia M4 aut |
700 | 1 | a Ebrahim, Shah4 aut |
700 | 1 | a Lawlor, Debbie A4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Harris, Tamara B4 aut |
700 | 1 | a Sørensen, Thorkild I A4 aut |
700 | 1 | a Mohlke, Karen L4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Lehtimäki, Terho4 aut |
700 | 1 | a Raitakari, Olli4 aut |
700 | 1 | a Isomaa, Bo4 aut |
700 | 1 | a Njølstad, Pål R4 aut |
700 | 1 | a Florez, Jose C4 aut |
700 | 1 | a Liu, Simin4 aut |
700 | 1 | a Ness, Andy4 aut |
700 | 1 | a Spector, Timothy D4 aut |
700 | 1 | a Tai, E Shyong4 aut |
700 | 1 | a Froguel, Philippe4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a Marmot, Michael4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Power, Chris4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Chasman, Daniel4 aut |
700 | 1 | a Ridker, Paul4 aut |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Monda, Keri L4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Järvelin, Marjo-Riitta4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Hu, Frank B4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Ekelund, Ulf4 aut |
700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin4 aut0 (Swepub:umu)pafr0003 |
700 | 1 | a Loos, Ruth J F4 aut |
710 | 2 | a Institutionen för kliniska vetenskaper, Malmöb Medicinska fakulteten4 org |
773 | 0 | t PLoS medicined : Public Library of Science (PLoS)g 8:11q 8:11x 1549-1676x 1549-1277 |
856 | 4 | u https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1001116&type=printable |
856 | 4 | u https://portal.research.lu.se/files/2386162/2544341.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1371/journal.pmed.1001116y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/152191 |
856 | 4 8 | u https://doi.org/10.1371/journal.pmed.1001116 |
856 | 4 8 | u https://lup.lub.lu.se/record/2348174 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-51101 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:123902905 |
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