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C-11 and F-18 Radio...
C-11 and F-18 Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates
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- Nordeman, Patrik (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
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- Johansson, Leif B. G. (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Bäck, Marcus (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Estrada, Sergio (author)
- Uppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
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- Hall, Håkan (author)
- Uppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
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- Sjölander, Daniel (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Westermark, Gunilla T. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Department of Medicinal Cell Biology, Uppsala University, Uppsala, Sweden
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- Westermark, Per (author)
- Uppsala universitet,Klinisk och experimentell patologi,Per Westermark,Department of Immunology, Genetics and Pathology, Uppsala University, UppsalaSweden
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- Nilsson, Lars (author)
- Univ Oslo, Dept Pharmacol, N-0316 Oslo, Norway.,Department of Pharmacology, University of Oslo, Oslo, Norway
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- Hammarström, Per (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Nilsson, K. Peter R. (author)
- Linköpings universitet,Kemi,Tekniska fakulteten
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- Antoni, Gunnar (author)
- Uppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2016-02-25
- 2016
- English.
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In: ACS Medicinal Chemistry Letters. - : American Chemical Society (ACS). - 1948-5875. ; 7:4, s. 368-373
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Three oligothiophenes were evaluated as PET ligands for the study of local and systemic amyloidosis ex vivo using tissue from patients with amyloid deposits and in vivo using healthy animals and PET-CT. The ex vivo binding studies revealed that all three labeled compounds bound specifically to human amyloid deposits. Specific binding was found in the heart, kidney, liver, and spleen. To verify the specificity of the oligothiophenes toward amyloid deposits, tissue sections with amyloid pathology were stained using the fluorescence exhibited by the compounds and evaluated with multiphoton microscopy. Furthermore, a in vivo monkey PET-CT study showed very low uptake in the brain, pancreas, and heart of the healthy animal indicating low nonspecific binding to healthy tissue. The biological evaluations indicated that this is a promising group of compounds for the visualization of systemic and localized amyloidosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- Positron emission tomography
- amyloidosis
- amyloid-beta
- transthyretin
- AL amyloidosis
- oligothiophenes
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nordeman, Patrik
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Johansson, Leif ...
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Bäck, Marcus
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Estrada, Sergio
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Hall, Håkan
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Sjölander, Danie ...
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Westermark, Guni ...
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Westermark, Per
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Nilsson, Lars
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Hammarström, Per
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Nilsson, K. Pete ...
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Antoni, Gunnar
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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ACS Medicinal Ch ...
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Uppsala University
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Linköping University