Sökning: (WFRF:(Hammarström Per)) srt2:(2015-2019) > C-11 and F-18 Radio...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 05507naa a2200649 4500 | |
001 | oai:DiVA.org:uu-296858 | |
003 | SwePub | |
008 | 160620s2016 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-122273 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2968582 URI |
024 | 7 | a https://doi.org/10.1021/acsmedchemlett.5b003092 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1222732 URI |
040 | a (SwePub)uud (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Nordeman, Patriku Uppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)patno435 |
245 | 1 0 | a C-11 and F-18 Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates |
264 | c 2016-02-25 | |
264 | 1 | b American Chemical Society (ACS),c 2016 |
338 | a print2 rdacarrier | |
500 | a Funding agencies: Swedish Research Council; Swedish Foundation for Strategic Research; LiU-Neuro; Ehrling-Persson Foundation; Goran-Gustafsson Foundation; ERC Starting Independent Researcher grant (Project: MUMID)Vid tiden för disputation förelåg publikationen som manuskript | |
520 | a Three oligothiophenes were evaluated as PET ligands for the study of local and systemic amyloidosis ex vivo using tissue from patients with amyloid deposits and in vivo using healthy animals and PET-CT. The ex vivo binding studies revealed that all three labeled compounds bound specifically to human amyloid deposits. Specific binding was found in the heart, kidney, liver, and spleen. To verify the specificity of the oligothiophenes toward amyloid deposits, tissue sections with amyloid pathology were stained using the fluorescence exhibited by the compounds and evaluated with multiphoton microscopy. Furthermore, a in vivo monkey PET-CT study showed very low uptake in the brain, pancreas, and heart of the healthy animal indicating low nonspecific binding to healthy tissue. The biological evaluations indicated that this is a promising group of compounds for the visualization of systemic and localized amyloidosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
650 | 7 | a NATURVETENSKAPx Kemi0 (SwePub)1042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Chemical Sciences0 (SwePub)1042 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a Positron emission tomography | |
653 | a amyloidosis | |
653 | a amyloid-beta | |
653 | a transthyretin | |
653 | a AL amyloidosis | |
653 | a oligothiophenes | |
653 | a Pathology | |
653 | a Patologi | |
700 | 1 | a Johansson, Leif B. G.u Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)leijo35 |
700 | 1 | a Bäck, Marcusu Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)marba90 |
700 | 1 | a Estrada, Sergiou Uppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.4 aut0 (Swepub:uu)seest517 |
700 | 1 | a Hall, Håkanu Uppsala universitet,Plattformen för Preklinisk PET-MRI,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.4 aut |
700 | 1 | a Sjölander, Danielu Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)dansj00 |
700 | 1 | a Westermark, Gunilla T.u Uppsala universitet,Institutionen för medicinsk cellbiologi,Department of Medicinal Cell Biology, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)gunwe105 |
700 | 1 | a Westermark, Peru Uppsala universitet,Klinisk och experimentell patologi,Per Westermark,Department of Immunology, Genetics and Pathology, Uppsala University, UppsalaSweden4 aut0 (Swepub:uu)perweste |
700 | 1 | a Nilsson, Larsu Univ Oslo, Dept Pharmacol, N-0316 Oslo, Norway.,Department of Pharmacology, University of Oslo, Oslo, Norway4 aut |
700 | 1 | a Hammarström, Peru Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)perha81 |
700 | 1 | a Nilsson, K. Peter R.u Linköpings universitet,Kemi,Tekniska fakulteten4 aut0 (Swepub:liu)petni61 |
700 | 1 | a Antoni, Gunnaru Uppsala universitet,Avdelningen för Molekylär Avbildning,Preclinical PET Platform, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)gunnarat |
710 | 2 | a Uppsala universitetb Avdelningen för Molekylär Avbildning4 org |
773 | 0 | t ACS Medicinal Chemistry Lettersd : American Chemical Society (ACS)g 7:4, s. 368-373q 7:4<368-373x 1948-5875 |
856 | 4 | u https://europepmc.org/articles/pmc4834648?pdf=render |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-296858 |
856 | 4 8 | u https://doi.org/10.1021/acsmedchemlett.5b00309 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-122273 |
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