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Dietary intake of f...
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Hedelin, M.Karolinska Institutet,Uppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset
(författare)
Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33 000 women from the general population
- Artikel/kapitelEngelska2010
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2010
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electronicrdacarrier
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LIBRIS-ID:oai:gup.ub.gu.se/124312
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https://gup.ub.gu.se/publication/124312URI
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https://doi.org/10.1186/1471-244X-10-38DOI
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https://research.chalmers.se/publication/124312URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-135682URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:120982960URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study among Swedish women. Methods: Dietary intake was estimated using a food frequency questionnaire among 33 623 women aged 30-49 years at enrolment (1991/92). Information on psychotic- like symptoms was derived from a follow-up questionnaire in the years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. The association between diet and psychotic- like symptoms was summarized in terms of relative risks (RR) and corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression. Results: 18 411 women were classified as having a low level of psychotic- like symptoms, 14 395 as middle and 817 as having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 times per week compared to women who never ate fish. The risk was also lower for women with a high intake of omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was 0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk of psychotic- like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic- like symptoms. Conclusion: Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and vitamin D have a lower rate of psychotic- like symptoms.
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Lof, M.Karolinska Institutet
(författare)
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Olsson, Marita,1965Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)marita
(författare)
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Lewander, TommyUppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset(Swepub:uu)tommlewa
(författare)
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Nilsson, B.Uppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset
(författare)
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Hultman, Christina M.Karolinska Institutet,Uppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset(Swepub:uu)chrihult
(författare)
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Weiderpass, E.Karolinska Institutet
(författare)
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Uppsala universitetPsykiatri, Ulleråker, Akademiska sjukhuset
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:BMC Psychiatry101471-244X
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