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Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis.
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- Braun, Attila (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Aszodi, Attila (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
- Hellebrand, Heide (author)
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- Berna, Alejandro (author)
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- (creator_code:org_t)
- 2002
- 2002
- English.
- In: Gene. - 1879-0038. ; 283:1-2, s. 219-225
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Profilins are small, widely expressed actin binding proteins, thought to be key regulators of actin dynamics in living cells. So far, three profilin-genes have been described: profilin-I (PFN1), profilin-II (PFN2) with two splice variants and the recently identified profilin-III (PFN3). Here we describe the genomic organization of the genes encoding human and mouse profilin-III. Both are single exon genes and lie in close vicinity to the renal sodium-phosphate transport gene 2 (SLC34A1, NPT2) which is highly expressed in kidney. Northern hybridization to rat tissues has previously demonstrated expression of an approximately 4.5 kb long profilin-III mRNA transcript in kidney and a mRNA transcript of approximately 1 kb in length in testis. Here we show that mouse profilin-III expression is restricted to testis and that the 4.2 kb profilin-III mRNA in kidney is the result of a slc34a1 transcript which includes the antisense profilin-III open reading frame in its 3prime prime or minute-untranslated region. Finally, we demonstrate by in situ hybridization that profilin-III mRNA is localized to cells in the late stage of spermatogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- In Situ Hybridization
- Human
- Gene Expression
- Kidney : metabolism
- Mice
- Male
- Mice Inbred Strains
- Microfilament Proteins : genetics
- Molecular Sequence Data
- Protein Isoforms : genetics
- RNA Messenger : genetics : metabolism
- Rats
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Alignment
- Sequence Homology Amino Acid
- Sequence Analysis DNA
- Transcription Genetic
- Testis : metabolism
- DNA : chemistry : genetics
- DNA Complementary : chemistry : genetics
- Blotting Northern
- Base Sequence
- Animal
- Amino Acid Sequence
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- art (subject category)
- ref (subject category)
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