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Sökning: (WFRF:(Hermansen Kjeld)) srt2:(2020-2023) > (2022) > Nordic dietary patt...

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FältnamnIndikatorerMetadata
00006193naa a2200637 4500
001oai:DiVA.org:uu-494014
003SwePub
008230116s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4940142 URI
0247 a https://doi.org/10.1007/s00125-022-05760-z2 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Massara, Paraskevi4 aut
2451 0a Nordic dietary patterns and cardiometabolic outcomes :b a systematic review and meta-analysis of prospective cohort studies and randomised controlled trials
264 c 2022-08-26
264 1b Springer,c 2022
338 a electronic2 rdacarrier
520 a AIMS/HYPOTHESIS: Nordic dietary patterns that are high in healthy traditional Nordic foods may have a role in the prevention and management of diabetes. To inform the update of the EASD clinical practice guidelines for nutrition therapy, we conducted a systematic review and meta-analysis of Nordic dietary patterns and cardiometabolic outcomes.METHODS: We searched MEDLINE, EMBASE and The Cochrane Library from inception to 9 March 2021. We included prospective cohort studies and RCTs with a follow-up of ≥1 year and ≥3 weeks, respectively. Two independent reviewers extracted relevant data and assessed the risk of bias (Newcastle-Ottawa Scale and Cochrane risk of bias tool). The primary outcome was total CVD incidence in the prospective cohort studies and LDL-cholesterol in the RCTs. Secondary outcomes in the prospective cohort studies were CVD mortality, CHD incidence and mortality, stroke incidence and mortality, and type 2 diabetes incidence; in the RCTs, secondary outcomes were other established lipid targets (non-HDL-cholesterol, apolipoprotein B, HDL-cholesterol, triglycerides), markers of glycaemic control (HbA1c, fasting glucose, fasting insulin), adiposity (body weight, BMI, waist circumference) and inflammation (C-reactive protein), and blood pressure (systolic and diastolic blood pressure). The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of the evidence.RESULTS: We included 15 unique prospective cohort studies (n=1,057,176, with 41,708 cardiovascular events and 13,121 diabetes cases) of people with diabetes for the assessment of cardiovascular outcomes or people without diabetes for the assessment of diabetes incidence, and six RCTs (n=717) in people with one or more risk factor for diabetes. In the prospective cohort studies, higher adherence to Nordic dietary patterns was associated with 'small important' reductions in the primary outcome, total CVD incidence (RR for highest vs lowest adherence: 0.93 [95% CI 0.88, 0.99], p=0.01; substantial heterogeneity: I2=88%, pQ<0.001), and similar or greater reductions in the secondary outcomes of CVD mortality and incidence of CHD, stroke and type 2 diabetes (p<0.05). Inverse dose-response gradients were seen for total CVD incidence, CVD mortality and incidence of CHD, stroke and type 2 diabetes (p<0.05). No studies assessed CHD or stroke mortality. In the RCTs, there were small important reductions in LDL-cholesterol (mean difference [MD] -0.26 mmol/l [95% CI -0.52, -0.00], pMD=0.05; substantial heterogeneity: I2=89%, pQ<0.01), and 'small important' or greater reductions in the secondary outcomes of non-HDL-cholesterol, apolipoprotein B, insulin, body weight, BMI and systolic blood pressure (p<0.05). For the other outcomes there were 'trivial' reductions or no effect. The certainty of the evidence was low for total CVD incidence and LDL-cholesterol; moderate to high for CVD mortality, established lipid targets, adiposity markers, glycaemic control, blood pressure and inflammation; and low for all other outcomes, with evidence being downgraded mainly because of imprecision and inconsistency.CONCLUSIONS/INTERPRETATION: Adherence to Nordic dietary patterns is associated with generally small important reductions in the risk of major CVD outcomes and diabetes, which are supported by similar reductions in LDL-cholesterol and other intermediate cardiometabolic risk factors. The available evidence provides a generally good indication of the likely benefits of Nordic dietary patterns in people with or at risk for diabetes.REGISTRATION: ClinicalTrials.gov NCT04094194.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a Cardiovascular disease
653 a Meta-analysis
653 a Nordic diet
653 a Prospective cohort
653 a Randomised controlled trial
653 a Systematic review
653 a Nutrition
653 a Nutrition
7001 a Zurbau, Andreea4 aut
7001 a Glenn, Andrea J.4 aut
7001 a Chiavaroli, Laura4 aut
7001 a Khan, Tauseef A.4 aut
7001 a Viguiliouk, Effie4 aut
7001 a Blanco Mejia, Sonia4 aut
7001 a Comelli, Elena M.4 aut
7001 a Chen, Victoria4 aut
7001 a Schwab, Ursula4 aut
7001 a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
7001 a Uusitupa, Matti4 aut
7001 a Aas, Anne-Marie4 aut
7001 a Hermansen, Kjeld4 aut
7001 a Thorsdottir, Inga4 aut
7001 a Rahelić, Dario4 aut
7001 a Kahleová, Hana4 aut
7001 a Salas-Salvadó, Jordi4 aut
7001 a Kendall, Cyril W. C.4 aut
7001 a Sievenpiper, John L.4 aut
7102 a Uppsala universitetb Klinisk nutrition och metabolism4 org
7730 t Diabetologiad : Springerg 65:12, s. 2011-2031q 65:12<2011-2031x 0012-186Xx 1432-0428
8564 u https://doi.org/10.1007/s00125-022-05760-zy Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1727213/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-494014
8564 8u https://doi.org/10.1007/s00125-022-05760-z

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