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Measures of adheren...
Measures of adherence in patients with severe asthma prescribed systemic steroids in the U-BIOPRED cohort
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Alahmadi, Fahad (author)
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Simpson, Andrew (author)
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Gomez, Christina (author)
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Wheelock, Craig (author)
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Shaw, Dominick (author)
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Fleming, Louise (author)
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Roberts, Graham (author)
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Riley, John (author)
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Bates, Stewart (author)
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Sousa, Ana R. (author)
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Knowles, Richard (author)
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Bansal, Aruna (author)
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Corfield, Julie (author)
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Pandis, Ioannis (author)
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Sun, Kai (author)
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Bakke, Per (author)
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Caruso, Massimo (author)
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Chanez, Pascal (author)
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Dahlen, Babro (author)
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Horvath, Ildiko (author)
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Krug, Norbert (author)
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Montuschi, Paolo (author)
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- Sandström, Thomas, 1957- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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Singer, Florian (author)
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Wagers, Scott (author)
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Adcock, Ian (author)
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Djukanovic, Ratko (author)
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Chung, Kian (author)
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Sterk, Peter J. (author)
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Dahlen, Sven-Erik (author)
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Fowler, Stephen J. (author)
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- English.
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In: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Introduction: Rates of sub-optimal adherence to medications in asthma range up to 70%; the impact in severe asthma is likely to be particularly high. We measured self-reported adherence in participants in the U-BIOPRED cohort prescribed daily prednisolone using the Medication Adherence Response Scale (MARS), and compared to measured urinary prednisolone and metabolites in order to determine: 1. the prevalence of suboptimal adherence by each method; 2. the ability of MARS to predict urinary steroid detection.Methods: Participants completed the MARS, and/or provided urine samples (analysed for prednisolone and metabolites by LCMS). The performance characteristics of the MARS predicting undetected urinary steroid were calculated in the subgroup having both tests.Results: 181 participants currently taking regular oral corticosteroids were included, 59% female, mean (SD) age 54(12)yrs, FEV1 64.7(20.4)% predicted. Sub-optimal adherence (MARS score < 4.5) was reported in 62 participants, and 76 did not have detectable urinary prednisolone or metabolites. Good adherence by both methods was detected in only 52 participants (34%, see table). There was no difference in daily prednisolone dose between detectable and undetectable metabolites groups (p=0.848).Conclusion: Low levels of adherence to treatment in severe asthma is a common problem, when measured either directly or self-reported. There was very poor agreement (48% concordance) between these two methods, and we suggest that, for now both approaches should be used.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- vet (subject category)
- art (subject category)
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- By the author/editor
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Alahmadi, Fahad
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Simpson, Andrew
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Gomez, Christina
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Wheelock, Craig
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Shaw, Dominick
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Fleming, Louise
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show more...
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Roberts, Graham
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Riley, John
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Bates, Stewart
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Sousa, Ana R.
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Knowles, Richard
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Bansal, Aruna
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Corfield, Julie
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Pandis, Ioannis
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Sun, Kai
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Bakke, Per
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Caruso, Massimo
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Chanez, Pascal
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Dahlen, Babro
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Horvath, Ildiko
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Krug, Norbert
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Montuschi, Paolo
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Sandström, Thoma ...
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Singer, Florian
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Wagers, Scott
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Adcock, Ian
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Djukanovic, Ratk ...
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Chung, Kian
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Sterk, Peter J.
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Dahlen, Sven-Eri ...
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Fowler, Stephen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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European Respira ...
- By the university
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Umeå University
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Karolinska Institutet