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Searching for Explanations for Cryptogenic Stroke in the Young : Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design
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- Putaala, Jukka (författare)
- Helsinki University Central Hospital
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- Martinez-Majander, Nicolas (författare)
- Helsinki University Central Hospital
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- Saeed, Sahrai (författare)
- University of Bergen
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- Yesilot, Nilufer (författare)
- Istanbul University
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- Jäkälä, Pekka (författare)
- Kuopio University Hospital
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- Nerg, Ossi (författare)
- Kuopio University Hospital
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- Tsivgoulis, Georgios (författare)
- National and Kapodistrian University of Athens,Attikon University Hospital
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- Numminen, Heikki (författare)
- Tampere University Hospital
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- Gordin, Daniel (författare)
- Folkhälsan Research Center,University of Helsinki
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- von Sarnowski, Bettina (författare)
- University of Greifswald
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- Waje-Andreassen, Ulrike (författare)
- Haukeland University Hospital
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- Ylikotila, Pauli (författare)
- Turku University Hospital,University of Turku
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- Roine, Risto O. (författare)
- Turku University Hospital,University of Turku
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- Zedde, Marialuisa (författare)
- Arcispedale Santa Maria Nuova
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- Huhtakangas, Juha (författare)
- Oulu University Hospital
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- Fonseca, Catarina (författare)
- Santa Maria Hospital, Lisbon,University of Lisbon
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- Redfors, Petra (författare)
- University of Gothenburg,Sahlgrenska University Hospital
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- de Leeuw, Frank Erik (författare)
- Radboud University Medical Center
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- Pezzini, Alessandro (författare)
- University of Brescia
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- Kõrv, Janika (författare)
- University of Tartu
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- Schneider, Siim (författare)
- North Estonia Medical Centre
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- Tanislav, Christian (författare)
- Justus Liebig University Giessen
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- Enzinger, Christian (författare)
- Medical University of Graz
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- Jatuzis, Dalius (författare)
- Vilnius University
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- Siegerink, Bob (författare)
- Charité - University Medicine Berlin
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- Martínez-Sánchez, Patricia (författare)
- Autonomous University of Madrid,University Hospital La Paz
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- Grau, Armin J. (författare)
- Klinikum Ludwigshafen
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- Palm, Frederick (författare)
- Klinikum Ludwigshafen
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- Groop, Per Henrik (författare)
- University of Helsinki,Folkhälsan Research Center
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- Lanthier, Sylvain (författare)
- University Of Montreal Health Center (CRCHUM)
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- Ten Cate, Hugo (författare)
- Maastricht University
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- Pussinen, Pirkko (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Paju, Susanna (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Sinisalo, Juha (författare)
- Helsinki University Central Hospital
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- Lehto, Mika (författare)
- Helsinki University Central Hospital
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- Lindgren, Arne (författare)
- Lund University,Lunds universitet,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Clinical Stroke Research Group,Lund University Research Groups,Skåne University Hospital
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- Ferro, José (författare)
- University of Lisbon,Santa Maria Hospital, Lisbon
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- Kittner, Steven (författare)
- Baltimore Veterans Administration Medical Center,University of Maryland
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- Fazekas, Franz (författare)
- Medical University of Graz
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- Gerdts, Eva (författare)
- University of Bergen
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- Tatlisumak, Turgut (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Helsinki University Central Hospital,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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(creator_code:org_t)
- 2017-04-04
- 2017
- Engelska 10 s.
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Ingår i: European Stroke Journal. - : SAGE Publications. - 2396-9873 .- 2396-9881. ; 2:2, s. 116-125
- Relaterad länk:
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http://dx.doi.org/10...
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https://journals.sag...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- Background: Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of these early-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions with poorly documented causality like patent foramen ovale and coagulopathies. Key hypotheses/aims: (1) Investigate transient triggers and clinical/sub-clinical chronic risk factors associated with cryptogenic IS in the young; (2) use cardiac imaging methods exceeding state-of-the-art to reveal novel sources for embolism; (3) search for covert thrombosis and haemostasis abnormalities; (4) discover new disease pathways using next-generation sequencing and RNA gene expression studies; (5) determine patient prognosis by use of phenotypic and genetic data; and (6) adapt systems medicine approach to investigate complex risk-factor interactions. Design: Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome (SECRETO; NCT01934725) is a prospective multi-centre case–control study enrolling patients aged 18–49 years hospitalised due to first-ever imaging-proven IS of undetermined etiology. Patients are examined according to a standardised protocol and followed up for 10 years. Patients are 1:1 age- and sex-matched to stroke-free controls. Key study elements include centralised reading of echocardiography, electrocardiography, and neurovascular imaging, as well as blood samples for genetic, gene-expression, thrombosis and haemostasis and biomarker analysis. We aim to have 600 patient–control pairs enrolled by the end of 2018. Summary: SECRETO is aiming to establish novel mechanisms and prognosis of cryptogenic IS in the young and will provide new directions for therapy development for these patients. First results are anticipated in 2019.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Brain infarction
- echocardiography
- electrocardiography
- embolism
- middle aged
- paradoxical embolism
- patent foramen ovale
- prognosis
- risk factors
- stroke
- thrombosis
- young adult
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Putaala, Jukka
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Martinez-Majande ...
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Saeed, Sahrai
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Yesilot, Nilufer
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Jäkälä, Pekka
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Nerg, Ossi
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visa fler...
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Tsivgoulis, Geor ...
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Numminen, Heikki
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Gordin, Daniel
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von Sarnowski, B ...
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Waje-Andreassen, ...
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Ylikotila, Pauli
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Roine, Risto O.
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Zedde, Marialuis ...
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Huhtakangas, Juh ...
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Fonseca, Catarin ...
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Redfors, Petra
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de Leeuw, Frank ...
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Pezzini, Alessan ...
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Kõrv, Janika
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Schneider, Siim
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Tanislav, Christ ...
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Enzinger, Christ ...
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Jatuzis, Dalius
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Siegerink, Bob
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Martínez-Sánchez ...
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Grau, Armin J.
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Palm, Frederick
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Groop, Per Henri ...
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Lanthier, Sylvai ...
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Ten Cate, Hugo
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Pussinen, Pirkko
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Paju, Susanna
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Sinisalo, Juha
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Lehto, Mika
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Lindgren, Arne
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Ferro, José
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Kittner, Steven
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Fazekas, Franz
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Gerdts, Eva
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Tatlisumak, Turg ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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European Stroke ...
- Av lärosätet
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Lunds universitet
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Göteborgs universitet