(WFRF:(Jacobs P.))
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02499naa a2200325 4500 | |
| 001 | oai:lup.lub.lu.se:b57a0e47-0246-4160-819f-c51515400cfc | |
| 003 | SwePub | |
| 008 | 190911s1990 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/b57a0e47-0246-4160-819f-c51515400cfc2 URI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Wilson, C. A.u University of Washington4 aut |
| 245 | 1 0 | a IL-1β modulation of spontaneous autoimmune diabetes and thyroiditis in the BB rat |
| 264 | 1 | c 1990 |
| 520 | a Long term effects of in vivo treatment with human rIL-1β on diabetogenesis and thyroid disease were determined in the Biobreeding rat. Administration of high dose (10 μg/kg) IL-1β accelerated the onset of insulin-dependent diabetes mellitus compared to saline-injected controls. High dose treatment resulted in goiter development, pronounced LT, reduced serum T4 levels, and overall growth reduction. In contrast, low dose IL-1β (0.5 μg/kg) administration significantly reduced the frequency of insulin-dependent diabetes mellitus (48%) compared to placebo (86%) and high dose IL-1β (93%) treatment groups. Rats protected by low dose IL-1β had unaffected growth rates and minimal to no pancreatic and thyroid pathology. Our results demonstrate that exogenous administration of IL-1β modulates Biobreeding rat idiopathic autoimmune diabetes and thyroid disease in a dose-dependent manner. | |
| 700 | 1 | a Jacobs, C.u University of Washington4 aut |
| 700 | 1 | a Baker, P.u University of Washington4 aut |
| 700 | 1 | a Baskin, D. G.u University of Washington4 aut |
| 700 | 1 | a Dower, S.u University of Washington4 aut |
| 700 | 1 | a Lernmark, A.u Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine,University of Washington4 aut0 (Swepub:lu)endo-ale |
| 700 | 1 | a Toivola, B.u University of Washington4 aut |
| 700 | 1 | a Vertrees, S.u University of Washington4 aut |
| 700 | 1 | a Wilson, D.u University of Washington4 aut |
| 710 | 2 | a University of Washingtonb Institutionen för translationell medicin4 org |
| 773 | 0 | t Journal of Immunologyg 144:10, s. 3784-3788q 144:10<3784-3788x 0022-1767 |
| 856 | 4 | u https://www.jimmunol.org/content/jimmunol/144/10/3784.full.pdfy FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/b57a0e47-0246-4160-819f-c51515400cfc |
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