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Genetic predisposit...
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
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- Steinthorsdottir, V (author)
- deCODE Genetics
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McGinnis, R (author)
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Williams, NO (author)
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show more...
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Stefansdottir, L (author)
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Thorleifsson, G (author)
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- Shooter, S (author)
- Karolinska Institutet
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- Fadista, Joao (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Danish Serum Institute, Copenhagen
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- Sigurdsson, JK (author)
- Karolinska Institutet
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Auro, KM (author)
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Berezina, G (author)
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Borges, MC (author)
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Bumpstead, S (author)
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Bybjerg-Grauholm, J (author)
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Colgiu, I (author)
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Dolby, VA (author)
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Dudbridge, F (author)
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Engel, SM (author)
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Franklin, CS (author)
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- Frigge, ML (author)
- University of Nottingham
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Frisbaek, Y (author)
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Geirsson, RT (author)
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Geller, F (author)
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Gretarsdottir, S (author)
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Gudbjartsson, DF (author)
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Harmon, Q (author)
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Hougaard, DM (author)
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Hegay, T (author)
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Helgadottir, A (author)
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Hjartardottir, S (author)
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Jaaskelainen, T (author)
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Johannsdottir, H (author)
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Jonsdottir, I (author)
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Juliusdottir, T (author)
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Kalsheker, N (author)
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Kasimov, A (author)
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Kemp, JP (author)
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Kivinen, K (author)
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Klungsoyr, K (author)
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Lee, WK (author)
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Melbye, M (author)
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Miedzybrodska, Z (author)
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Moffett, A (author)
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Najmutdinova, D (author)
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Nishanova, F (author)
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Olafsdottir, T (author)
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Perola, M (author)
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Pipkin, FB (author)
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Poston, L (author)
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Prescott, G (author)
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- Saevarsdottir, S (author)
- Karolinska Institutet
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Salimbayeva, D (author)
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Scaife, PJ (author)
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Skotte, L (author)
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Staines-Urias, E (author)
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Stefansson, OA (author)
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Sorensen, KM (author)
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Thomsen, LCV (author)
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Tragante, V (author)
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Trogstad, L (author)
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Simpson, NAB (author)
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Laivuori, H (author)
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Morgan, L (author)
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Aripova, T (author)
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Casas, JP (author)
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Dominiczak, AF (author)
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Walker, JJ (author)
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Thorsteinsdottir, U (author)
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Iversen, AC (author)
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Feenstra, B (author)
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Lawlor, DA (author)
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Boyd, HA (author)
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Magnus, P (author)
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Laivuori, H (author)
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Zakhidova, N (author)
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Svyatova, G (author)
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Stefansson, K (author)
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Morgan, L (author)
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Laivuori, H (author)
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Heinonen, S (author)
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Kajantie, E (author)
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- Kere, J (author)
- Karolinska Institutet
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Kivinen, K (author)
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Pouta, A (author)
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Morgan, L (author)
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Pipkin, FB (author)
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Kalsheker, N (author)
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Walker, JJ (author)
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Macphail, S (author)
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Kilby, M (author)
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Habiba, M (author)
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Williamson, C (author)
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O'Shaughnessy, K (author)
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O'Brien, S (author)
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Cameron, A (author)
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Redman, CWG (author)
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Farrall, M (author)
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Caulfield, M (author)
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Dominiczak, AF (author)
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(creator_code:org_t)
- 2020-11-25
- 2020
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 5976-
- Related links:
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- blood
- body mass
- genome
- meta-analysis
- public health
- risk assessment
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Steinthorsdottir ...
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McGinnis, R
-
Williams, NO
-
Stefansdottir, L
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Thorleifsson, G
-
Shooter, S
-
show more...
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Fadista, Joao
-
Sigurdsson, JK
-
Auro, KM
-
Berezina, G
-
Borges, MC
-
Bumpstead, S
-
Bybjerg-Grauholm ...
-
Colgiu, I
-
Dolby, VA
-
Dudbridge, F
-
Engel, SM
-
Franklin, CS
-
Frigge, ML
-
Frisbaek, Y
-
Geirsson, RT
-
Geller, F
-
Gretarsdottir, S
-
Gudbjartsson, DF
-
Harmon, Q
-
Hougaard, DM
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Hegay, T
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Helgadottir, A
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Hjartardottir, S
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Jaaskelainen, T
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Johannsdottir, H
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Jonsdottir, I
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Juliusdottir, T
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Kalsheker, N
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Kasimov, A
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Kemp, JP
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Kivinen, K
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Klungsoyr, K
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Lee, WK
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Melbye, M
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Miedzybrodska, Z
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Moffett, A
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Najmutdinova, D
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Nishanova, F
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Olafsdottir, T
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Perola, M
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Pipkin, FB
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Poston, L
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Prescott, G
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Saevarsdottir, S
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Salimbayeva, D
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Scaife, PJ
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Skotte, L
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Staines-Urias, E
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Stefansson, OA
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Sorensen, KM
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Thomsen, LCV
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Tragante, V
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Trogstad, L
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Simpson, NAB
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Laivuori, H
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Morgan, L
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Aripova, T
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Casas, JP
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Dominiczak, AF
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Walker, JJ
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Thorsteinsdottir ...
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Iversen, AC
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Feenstra, B
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Lawlor, DA
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Boyd, HA
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Magnus, P
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Zakhidova, N
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Svyatova, G
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Stefansson, K
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Heinonen, S
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Kajantie, E
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Kere, J
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Pouta, A
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Macphail, S
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Kilby, M
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Habiba, M
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Williamson, C
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O'Shaughnessy, K
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O'Brien, S
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Cameron, A
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Redman, CWG
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Farrall, M
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Caulfield, M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Lund University