Search: (WFRF:(Krogh Vittorio)) pers:(Agudo Antonio) pers:(Olsen Anja) pers:(Khaw Kay Tee) >
Body iron status an...
Body iron status and gastric cancer risk in the EURGAST study.
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Fonseca-Nunes, Ana (author)
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Agudo, Antonio (author)
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Aranda, Núria (author)
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Arija, Victoria (author)
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Cross, Amanda J (author)
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Molina, Esther (author)
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Sanchez, Maria Jose (author)
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Bueno-de-Mesquita, Bas (author)
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Siersema, Peter (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Krogh, Vittorio (author)
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Mattiello, Amalia (author)
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Tumino, Rosario (author)
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Saieva, Calogero (author)
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Naccarati, Alessio (author)
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups
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Boutron-Ruault, Marie-Christine (author)
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Cadeau, Claire (author)
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Fagherazzi, Guy (author)
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Boeing, Heiner (author)
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Steffen, Annika (author)
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Kühn, Tilman (author)
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Katzke, Verena (author)
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Tjønneland, Anne (author)
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Olsen, Anja (author)
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Key, Tim (author)
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- Lu, Yunxia (author)
- Karolinska Institutet
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Riboli, Elio (author)
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Peeters, Petra H (author)
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Gavrila, Diana (author)
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Dorronsoro, Miren (author)
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Quirós, José Ramón (author)
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Barricarte, Aurelio (author)
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Jenab, Mazda (author)
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Zamora-Ros, Raúl (author)
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Freisling, Heinz (author)
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Trichopoulou, Antonia (author)
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Lagiou, Pagona (author)
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Bamia, Christina (author)
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Jakszyn, Paula (author)
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(creator_code:org_t)
- 2015-07-16
- 2015
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 137:12, s. 2904-2914
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Although it appears biologically plausible for iron to be associated with gastric carcinogenesis, the evidence is insufficient to lead to any conclusions. To further investigate the relationship between body iron status and gastric cancer risk, we conducted a nested case-control study in the multicentric European Prospective Investigation into Cancer and Nutrition (EPIC) study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured prediagnostic serum iron, ferritin, transferrin and C-reactive protein, and further estimated total iron-binding capacity (TIBC) and transferrin saturation (TS). Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by iron metrics were estimated from multivariable conditional logistic regression models. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and ferritin and TS indices (ORlog2 = 0.80, 95% CI = 0.72-0.88; OR10%increment = 0.87, 95% CI = 0.78-0.97, respectively). These associations appear to be restricted to noncardia gastric cancer (ferritin showed a p for heterogeneity = 0.04 and TS had a p for heterogeneity = 0.02), and no differences were found by histological type. TIBC increased risk of overall gastric cancer (OR50 µg/dl = 1.13, 95% CI = 1.02-1.2) and also with noncardia gastric cancer (p for heterogeneity = 0.04). Additional analysis suggests that time between blood draw and gastric cancer diagnosis could modify these findings. In conclusion, our results showed a decreased risk of gastric cancer related to higher body iron stores as measured by serum iron and ferritin. Further investigation is needed to clarify the role of iron in gastric carcinogenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Fonseca-Nunes, A ...
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Agudo, Antonio
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Aranda, Núria
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Arija, Victoria
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Cross, Amanda J
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Molina, Esther
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show more...
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Sanchez, Maria J ...
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Bueno-de-Mesquit ...
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Siersema, Peter
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Weiderpass, Elis ...
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Krogh, Vittorio
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Mattiello, Amali ...
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Tumino, Rosario
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Saieva, Calogero
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Naccarati, Aless ...
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Ohlsson, Bodil
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Sjöberg, Klas
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Boutron-Ruault, ...
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Cadeau, Claire
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Fagherazzi, Guy
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Boeing, Heiner
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Steffen, Annika
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Kühn, Tilman
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Katzke, Verena
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Tjønneland, Anne
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Olsen, Anja
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Khaw, Kay-Tee
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Wareham, Nick
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Key, Tim
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Lu, Yunxia
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Riboli, Elio
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Peeters, Petra H
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Gavrila, Diana
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Dorronsoro, Mire ...
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Quirós, José Ram ...
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Barricarte, Aure ...
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Jenab, Mazda
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Zamora-Ros, Raúl
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Freisling, Heinz
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Trichopoulou, An ...
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Lagiou, Pagona
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Bamia, Christina
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Jakszyn, Paula
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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International Jo ...
- By the university
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Lund University
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Karolinska Institutet