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Genome-wide meta-an...
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
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Klein, Alison P. (author)
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Wolpin, Brian M. (author)
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Risch, Harvey A. (author)
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show more...
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Stolzenberg-Solomon, Rachael Z. (author)
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Mocci, Evelina (author)
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Zhang, Mingfeng (author)
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Canzian, Federico (author)
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Childs, Erica J. (author)
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Hoskins, Jason W. (author)
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Jermusyk, Ashley (author)
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Zhong, Jun (author)
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Chen, Fei (author)
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Albanes, Demetrius (author)
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Andreotti, Gabriella (author)
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Arslan, Alan A. (author)
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Babic, Ana (author)
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Bamlet, William R. (author)
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Beane-Freeman, Laura (author)
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Berndt, Sonja I. (author)
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Blackford, Amanda (author)
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Borges, Michael (author)
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Borgida, Ayelet (author)
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Bracci, Paige M. (author)
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Brais, Lauren (author)
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Brennan, Paul (author)
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Brenner, Hermann (author)
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Bueno-de-Mesquita, Bas (author)
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Buring, Julie (author)
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Campa, Daniele (author)
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Capurso, Gabriele (author)
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Cavestro, Giulia Martina (author)
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Chaffee, Kari G. (author)
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Chung, Charles C. (author)
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Cleary, Sean (author)
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Cotterchio, Michelle (author)
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Dijk, Frederike (author)
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Duell, Eric J. (author)
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Foretova, Lenka (author)
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Fuchs, Charles (author)
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Funel, Niccola (author)
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Gallinger, Steven (author)
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Gaziano, J. Michael M. (author)
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Gazouli, Maria (author)
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Giles, Graham G. (author)
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Giovannucci, Edward (author)
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Goggins, Michael (author)
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Goodman, Gary E. (author)
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Goodman, Phyllis J. (author)
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Hackert, Thilo (author)
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Haiman, Christopher (author)
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Hartge, Patricia (author)
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Hasan, Manal (author)
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Hegyi, Peter (author)
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Helzlsouer, Kathy J. (author)
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Herman, Joseph (author)
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Holcatova, Ivana (author)
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Holly, Elizabeth A. (author)
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Hoover, Robert (author)
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Hung, Rayjean J. (author)
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Jacobs, Eric J. (author)
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Jamroziak, Krzysztof (author)
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Janout, Vladimir (author)
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Kaaks, Rudolf (author)
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Khaw, Kay-Tee (author)
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Klein, Eric A. (author)
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Kogevinas, Manolis (author)
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Kooperberg, Charles (author)
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Kulke, Matthew H. (author)
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Kupcinskas, Juozas (author)
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Kurtz, Robert J. (author)
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Laheru, Daniel (author)
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Landi, Stefano (author)
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Lawlor, Rita T. (author)
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Lee, I. -Min (author)
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LeMarchand, Loic (author)
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Lu, Lingeng (author)
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Malats, Nuria (author)
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Mambrini, Andrea (author)
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Mannisto, Satu (author)
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Milne, Roger L. (author)
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Mohelnikova-Duchonova, Beatrice (author)
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Neale, Rachel E. (author)
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Neoptolemos, John P. (author)
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Oberg, Ann L. (author)
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Olson, Sara H. (author)
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Orlow, Irene (author)
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Pasquali, Claudio (author)
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Patel, Alpa V. (author)
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Peters, Ulrike (author)
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Pezzilli, Raffaele (author)
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Porta, Miquel (author)
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Real, Francisco X. (author)
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Rothman, Nathaniel (author)
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Scelo, Ghislaine (author)
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Sesso, Howard D. (author)
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Severi, Gianluca (author)
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Shu, Xiao-Ou (author)
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Silverman, Debra (author)
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Smith, Jill P. (author)
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Soucek, Pavel (author)
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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Talar-Wojnarowska, Renata (author)
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Tavano, Francesca (author)
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Thornquist, Mark D. (author)
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Tobias, Geoffrey S. (author)
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Van Den Eeden, Stephen K. (author)
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Vashist, Yogesh (author)
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Visvanathan, Kala (author)
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Vodicka, Pavel (author)
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Wactawski-Wende, Jean (author)
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Wang, Zhaoming (author)
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Wentzensen, Nicolas (author)
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White, Emily (author)
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Yu, Herbert (author)
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Yu, Kai (author)
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Zeleniuch-Jacquotte, Anne (author)
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Zheng, Wei (author)
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Kraft, Peter (author)
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Li, Donghui (author)
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Chanock, Stephen (author)
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Obazee, Ofure (author)
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Petersen, Gloria M. (author)
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Amundadottir, Laufey T. (author)
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(creator_code:org_t)
- 2018-02-08
- 2018
- English.
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In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 x 10(-8)). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PAN-DoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 x 10(-14)), rs2941471 at 8q21.11 (HNF4G, P = 6.60 x 10(-10)), rs4795218 at 17q12 (HNF1B, P = 1.32 x 10(-8)), and rs1517037 at 18q21.32 (GRP, P = 3.28 x 10(-8)). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Klein, Alison P.
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Wolpin, Brian M.
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Risch, Harvey A.
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Stolzenberg-Solo ...
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Mocci, Evelina
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Zhang, Mingfeng
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show more...
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Canzian, Federic ...
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Childs, Erica J.
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Hoskins, Jason W ...
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Jermusyk, Ashley
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Zhong, Jun
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Chen, Fei
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Albanes, Demetri ...
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Andreotti, Gabri ...
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Arslan, Alan A.
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Babic, Ana
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Bamlet, William ...
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Beane-Freeman, L ...
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Berndt, Sonja I.
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Blackford, Amand ...
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Borges, Michael
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Borgida, Ayelet
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Bracci, Paige M.
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Brais, Lauren
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Brennan, Paul
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Brenner, Hermann
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Bueno-de-Mesquit ...
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Buring, Julie
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Campa, Daniele
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Capurso, Gabriel ...
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Cavestro, Giulia ...
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Chaffee, Kari G.
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Chung, Charles C ...
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Cleary, Sean
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Cotterchio, Mich ...
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Dijk, Frederike
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Duell, Eric J.
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Foretova, Lenka
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Fuchs, Charles
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Funel, Niccola
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Gallinger, Steve ...
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Gaziano, J. Mich ...
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Gazouli, Maria
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Giles, Graham G.
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Giovannucci, Edw ...
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Goggins, Michael
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Goodman, Gary E.
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Goodman, Phyllis ...
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Hackert, Thilo
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Haiman, Christop ...
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Hartge, Patricia
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Hasan, Manal
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Hegyi, Peter
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Helzlsouer, Kath ...
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Herman, Joseph
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Holcatova, Ivana
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Holly, Elizabeth ...
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Hoover, Robert
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Hung, Rayjean J.
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Jacobs, Eric J.
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Jamroziak, Krzys ...
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Janout, Vladimir
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Kaaks, Rudolf
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Khaw, Kay-Tee
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Klein, Eric A.
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Kogevinas, Manol ...
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Kooperberg, Char ...
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Kulke, Matthew H ...
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Kupcinskas, Juoz ...
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Kurtz, Robert J.
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Laheru, Daniel
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Landi, Stefano
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Lawlor, Rita T.
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Lee, I. -Min
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LeMarchand, Loic
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Lu, Lingeng
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Malats, Nuria
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Mambrini, Andrea
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Mannisto, Satu
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Milne, Roger L.
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Mohelnikova-Duch ...
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Neale, Rachel E.
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Neoptolemos, Joh ...
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Oberg, Ann L.
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Olson, Sara H.
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Orlow, Irene
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Pasquali, Claudi ...
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Patel, Alpa V.
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Peters, Ulrike
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Pezzilli, Raffae ...
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Porta, Miquel
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Real, Francisco ...
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Rothman, Nathani ...
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Scelo, Ghislaine
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Sesso, Howard D.
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Severi, Gianluca
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Shu, Xiao-Ou
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Silverman, Debra
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Smith, Jill P.
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Soucek, Pavel
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Sund, Malin
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Talar-Wojnarowsk ...
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Tavano, Francesc ...
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Thornquist, Mark ...
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Tobias, Geoffrey ...
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Van Den Eeden, S ...
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Vashist, Yogesh
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Visvanathan, Kal ...
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Vodicka, Pavel
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Wactawski-Wende, ...
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Wang, Zhaoming
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Wentzensen, Nico ...
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White, Emily
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Yu, Herbert
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Yu, Kai
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Zeleniuch-Jacquo ...
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Zheng, Wei
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Kraft, Peter
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Li, Donghui
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Chanock, Stephen
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Obazee, Ofure
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Petersen, Gloria ...
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Amundadottir, La ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Umeå University