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No evidence that GA...
No evidence that GATA3 rs570613 SNP modifies breast cancer risk
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Johnatty, S. E. (author)
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Couch, F. J. (author)
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Fredericksen, Z. (author)
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show more...
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Tarrell, R. (author)
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- Bergman, Annika, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics,The Swedish BRCA1 and BRCA2 Study, Lund University Hospital, Lund, Sweden, and Karolinska University Hospital, Stockholm, Sweden
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Beesley, J. (author)
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Chen, X. (author)
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Gschwantler-Kaulich, D. (author)
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Singer, C. F. (author)
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Fuerhauser, C. (author)
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Fink-Retter, A. (author)
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Domchek, S. M. (author)
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Nathanson, K. L. (author)
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Pankratz, V. S. (author)
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- Nordling, Margareta, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Godwin, A. K. (author)
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Caligo, M. A. (author)
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Hopper, J. (author)
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Southey, M. C. (author)
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Giles, G. G. (author)
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Justenhoven, C. (author)
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Brauch, H. (author)
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Hamann, U. (author)
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Ko, Y. -D (author)
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Heikkinen, T. (author)
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Aaltonen, K. (author)
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Aittomäki, K. (author)
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- Blomqvist, C. (author)
- Uppsala universitet,Enheten för onkologi
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Nevanlinna, H. (author)
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- Hall, P. (author)
- Karolinska Institutet
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- Czene, K. (author)
- Karolinska Institutet
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Liu, J. (author)
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Peock, S. (author)
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Cook, M. (author)
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Platte, R. (author)
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Gareth Evans, D. (author)
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Lalloo, F. (author)
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Eeles, R. (author)
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Pichert, G. (author)
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Eccles, D. (author)
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Davidson, R. (author)
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Cole, T. (author)
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Cook, J. (author)
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Douglas, F. (author)
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Chu, C. (author)
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Hodgson, S. (author)
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Paterson, J. (author)
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Hogervorst, F. B. L. (author)
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Rookus, M. A. (author)
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Seynaeve, C. (author)
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Wijnen, J. (author)
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Vreeswijk, M. (author)
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Ligtenberg, M. (author)
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Van Der Luijt, R. B. (author)
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Van Os, T. A. M. (author)
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Gille, H. J. P. (author)
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Blok, M. J. (author)
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Issacs, C. (author)
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Humphreys, M. K. (author)
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McGuffog, L. (author)
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Healey, S. (author)
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Sinilnikova, O. (author)
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Antoniou, A. C. (author)
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Easton, D. F. (author)
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Chenevix-Trench, G. (author)
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- Bergman, Annika (contributor)
- The Swedish BRCA1 and BRCA2 Study, Lund University Hospital, Lund, Sweden, and Karolinska University Hospital, Stockholm, Sweden
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- Einbeigi, Zakaria, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Gomez-Garcia, E. (author)
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Spurdle, Amanda (author)
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Lindor, Noralane (author)
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show less...
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(creator_code:org_t)
- 2008-12-11
- 2009
- English.
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In: Breast Cancer Research and Treatment. - : Springer. - 0167-6806 .- 1573-7217. ; 117:2, s. 371-379
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- GATA-binding protein 3 (GATA3) is a transcription factor that is crucial to mammary gland morphogenesis and differentiation of progenitor cells, and has been suggested to have a tumor suppressor function. The rs570613 single nucleotide polymorphism (SNP) in intron 4 of GATA3 was previously found to be associated with a reduction in breast cancer risk in the Cancer Genetic Markers of Susceptibility project and in pooled analysis of two case-control studies from Norway and Poland (P trend = 0.004), with some evidence for a stronger association with estrogen receptor (ER) negative tumours [Garcia-Closas M et al. (2007) Cancer Epidemiol Biomarkers Prev 16:2269-2275]. We genotyped GATA3 rs570613 in 6,388 cases and 4,995 controls from the Breast Cancer Association Consortium (BCAC) and 5,617 BRCA1 and BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). We found no association between this SNP and breast cancer risk in BCAC cases overall (ORper-allele = 1.00, 95% CI 0.94-1.05), in ER negative BCAC cases (ORper-allele = 1.02, 95% CI 0.91-1.13), in BRCA1 mutation carriers RRper-allele = 0.99, 95% CI 0.90-1.09) or BRCA2 mutation carriers (RRper-allele = 0.93, 95% CI 0.80-1.07). We conclude that there is no evidence that either GATA3 rs570613, or any variant in strong linkage disequilibrium with it, is associated with breast cancer risk in women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- BRCA1 and BRCA2
- Breast cancer
- GATA3
- Polymorphism
- Risk
- estrogen receptor
- transcription factor GATA 3
- adult
- allele
- article
- BRCA2 oncogene
- cancer risk
- cell differentiation
- controlled study
- female
- GATA3 gene
- gene linkage disequilibrium
- genetic association
- genetic marker
- genotype
- human
- intron
- major clinical study
- mammary gland
- morphogenesis
- Norway
- oncogene
- Poland
- priority journal
- risk reduction
- single nucleotide polymorphism
- stem cell
- Breast Neoplasms
- GATA3 Transcription Factor
- Genes
- BRCA1
- Genes
- BRCA2
- Genetic Predisposition to Disease
- Humans
- Linkage Disequilibrium
- Mutation
- Polymorphism
- Single Nucleotide
- Risk Factors
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Johnatty, S. E.
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Couch, F. J.
-
Fredericksen, Z.
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Tarrell, R.
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Bergman, Annika, ...
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Beesley, J.
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show more...
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Chen, X.
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Gschwantler-Kaul ...
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Singer, C. F.
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Fuerhauser, C.
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Fink-Retter, A.
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Domchek, S. M.
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Nathanson, K. L.
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Pankratz, V. S.
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Nordling, Margar ...
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Godwin, A. K.
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Caligo, M. A.
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Hopper, J.
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Southey, M. C.
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Giles, G. G.
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Justenhoven, C.
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Brauch, H.
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Hamann, U.
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Ko, Y. -D
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Heikkinen, T.
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Aaltonen, K.
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Aittomäki, K.
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Blomqvist, C.
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Nevanlinna, H.
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Hall, P.
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Czene, K.
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Liu, J.
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Peock, S.
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Cook, M.
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Platte, R.
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Gareth Evans, D.
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Lalloo, F.
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Eeles, R.
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Pichert, G.
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Eccles, D.
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Davidson, R.
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Cole, T.
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Cook, J.
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Douglas, F.
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Chu, C.
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Hodgson, S.
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Paterson, J.
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Hogervorst, F. B ...
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Rookus, M. A.
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Seynaeve, C.
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Wijnen, J.
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Vreeswijk, M.
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Ligtenberg, M.
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Van Der Luijt, R ...
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Van Os, T. A. M.
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Gille, H. J. P.
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Blok, M. J.
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Issacs, C.
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Humphreys, M. K.
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McGuffog, L.
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Healey, S.
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Sinilnikova, O.
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Antoniou, A. C.
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Easton, D. F.
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Chenevix-Trench, ...
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Bergman, Annika
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Einbeigi, Zakari ...
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Gomez-Garcia, E.
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Spurdle, Amanda
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Lindor, Noralane
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Breast Cancer Re ...
- By the university
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Jönköping University
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University of Gothenburg
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Uppsala University
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Karolinska Institutet