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Elevated levels of ...
Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
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- Olsson, Sara K. (author)
- Karolinska Institutet,Karolinska Institute
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- Samuelsson, Martin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Saetre, Peter (author)
- Karolinska Institute and Hospital
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- Lindström, Leif (author)
- Uppsala universitet,Psykiatri, Ulleråker, Akademiska sjukhuset,Uppsala University
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- Jönsson, Erik G. (author)
- Karolinska Institutet,Karolinska Institute and Hospital
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- Nordin, Conny (author)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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- Engberg, Göran (author)
- Karolinska Institutet,Karolinska Institute
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- Erhardt, Sophie (author)
- Karolinska Institutet,Karolinska Institute
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Karolinska Institute
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(creator_code:org_t)
- 2010-05-01
- 2010
- English.
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In: Journal of Psychiatry & Neuroscience. - : CMA Joule Inc.. - 1180-4882 .- 1488-2434. ; 35:3, s. 195-199
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Abstract
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- Background: Patients with schizophrenia show elevated brain levels of the neuroactive tryptophan metabolite kynurenic acid (KYNA) This astrocyte] derived mediator acts as a neuroprotectant and modulates sensory gating and cognitive functiona We measured the levels of KYNA in the cerebrospinal fluid T vSyU of patients with bipolar disorder and healthy volunteers to investigate the putative involvement of KYNA in bipolar disorder. Methods: We obtained CSF by lumbar puncture from 23 healthy men and 31 euthymic men with bipolar disorder. We analyzed the samples using high] performance liquid chromatography. Results: Patients with bipolar disorder had increased levels of KYNA in their CSF compared with healthy volunteers (1.71 nM, standard error of the mean [SEM] cad, va dad, nM, SEM cacln p = 0.002. The levels of KYNA were positively correlated with age among bipolar patients but not healthy volunteersa Limitations: The influence of ongoing drug treatment among patients cannot be ruled outa We conducted our study during the euthymic phase of the diseasea Conclusion: Brain KYNA levels are increased in euthymic men with bipolar disorder. In addition, KYNA levels increased with age in these patientsa These findings indicate shared mechanisms between bipolar disorder and schizophrenia. Elevated levels of brain KYNA may provide further insight to the pathophysiology and progression of bipolar disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Olsson, Sara K.
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Samuelsson, Mart ...
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Saetre, Peter
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Lindström, Leif
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Jönsson, Erik G.
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Nordin, Conny
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show more...
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Engberg, Göran
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Erhardt, Sophie
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Landén, Mikael, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Journal of Psych ...
- By the university
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Uppsala University
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University of Gothenburg
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Karolinska Institutet
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Linköping University