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Kumar, AbhinavInstitute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Elsevier BV,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-327974
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327974URI
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https://doi.org/10.1016/j.nano.2017.06.008DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141976URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Most inhaled nanomedicines in development are for the treatment of lung disease, yet little is known about their interaction with the respiratory tract lining fluids (RTLFs). Here we combined the use of nano-silica, as a protein concentrator, with label-free snapshot proteomics (LC-MS/MS; key findings confirmed by ELISA) to generate a quantitative profile of the RTLF proteome and provided insight into the evolved corona; information that may be used in future to improve drug targeting to the lungs by inhaled medicines. The asthmatic coronal proteome displayed a reduced contribution of surfactant proteins (SP-A and B) and a higher contribution of α1-antitrypsin. Pathway analysis suggested that asthmatic RTLFs may also be deficient in proteins related to metal handling (e.g. lactoferrin). This study demonstrates how the composition of the corona acquired by inhaled nanoparticles is modified in asthma and suggests depressed mucosal immunity even in mild airway disease.
Subject headings and genre
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Bicer, Elif MelisMRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
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Pfeffer, PaulMRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK,Pharmaceutical and Medical Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
(author)
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Monopoli, Marco PPharmaceutical and Medical Chemistry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.; Centre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
(author)
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Dawson, Kenneth ACentre for BioNano Interactions, University College Dublin, Dublin 4, Ireland
(author)
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Eriksson, JonnyUppsala universitet,Analytisk kemi,Edwards grupp(Swepub:uu)joeri841
(author)
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Edwards, KatarinaUppsala universitet,Analytisk kemi,Edwards grupp(Swepub:uu)kataedwa
(author)
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Lynham, StevenInstitute of Psychiatry, Psychology and Neuroscience, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
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Arno, MatthewGenomics Centre, Faculty of Life Sciences and Medicine, King's College, London
(author)
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Behndig, Annelie F.Umeå universitet,Lungmedicin,Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden(Swepub:umu)anbe0145
(author)
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Blomberg, AndersUmeå universitet,Lungmedicin,Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden(Swepub:umu)anbl0001
(author)
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Somers, GrahamGSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
(author)
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Hassall, DaveGSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK
(author)
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Dailey, Lea AnnInstitute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
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Forbes, BenInstitute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
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Mudway, IanMRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK
(author)
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Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College, London, UKMRC-PHE Centre for Environment and Health, Analytical & Environmental Sciences Division, Faculty of Life Sciences and Medicine, King's College, London, UK
(creator_code:org_t)
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In:Nanomedicine: Elsevier BV13:8, s. 2517-25211549-96341549-9642
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Kumar, Abhinav
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Bicer, Elif Meli ...
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Pfeffer, Paul
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Monopoli, Marco ...
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Dawson, Kenneth ...
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Eriksson, Jonny
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Edwards, Katarin ...
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Lynham, Steven
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Arno, Matthew
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Blomberg, Anders
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Somers, Graham
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Hassall, Dave
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Dailey, Lea Ann
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Forbes, Ben
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Mudway, Ian
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Nanomedicine
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Uppsala University
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Umeå University