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Traumatic Brain Inj...
Traumatic Brain Injury and Alzheimer's Disease: The Cerebrovascular Link
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Ramos-Cejudo, J. (author)
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Wisniewski, T. (author)
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Marmar, C. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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de Leon, M. J. (author)
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Fossati, S. (author)
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 28, s. 21-30
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http://www.thelancet...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological disorders, whose complex relationship is not completely understood. Cerebrovascular pathology, a key element in both conditions, could represent amechanistic link between A beta/tau deposition after TBI and the development of post concussive syndrome, dementia and chronic traumatic encephalopathy (CTE). In addition to debilitating acute effects, TBI-induced neurovascular injuries accelerate amyloid beta (A beta) production and perivascular accumulation, arterial stiffness, tau hyperphosphorylation and tau/A beta-induced blood brain barrier damage, giving rise to a deleterious feed-forward loop. We postulate that TBI can initiate cerebrovascular pathology, which is causally involved in the development of multiple forms of neurodegeneration including AD-like dementias. In this review, we will explore hownovel biomarkers, animal and human studies with a focus on cerebrovascular dysfunction are contributing to the understanding of the consequences of TBI on the development of AD-like pathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Traumatic brain injury
- Alzheimer's disease
- Cerebrovascular pathology
- Biomarkers
- A beta
- Tau
- white-matter damage
- cerebral amyloid angiopathy
- endothelial
- nitric-oxide
- total tau
- cerebrospinal-fluid
- blood biomarkers
- murine
- model
- mouse model
- cognitive impairment
- neurovascular unit
- General & Internal Medicine
- Research & Experimental Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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