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Genome-wide associa...
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
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Berndt, Sonja I. (author)
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Skibola, Christine F. (author)
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Joseph, Vijai (author)
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show more...
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Camp, Nicola J. (author)
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Nieters, Alexandra (author)
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Wang, Zhaoming (author)
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Cozen, Wendy (author)
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Monnereau, Alain (author)
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Wang, Sophia S. (author)
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Kelly, Rachel S. (author)
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Lan, Qing (author)
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Teras, Lauren R. (author)
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Chatterjee, Nilanjan (author)
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Chung, Charles C. (author)
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Yeager, Meredith (author)
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Brooks-Wilson, Angela R. (author)
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Hartge, Patricia (author)
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Purdue, Mark P. (author)
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Birmann, Brenda M. (author)
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Armstrong, Bruce K. (author)
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Cocco, Pierluigi (author)
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Zhang, Yawei (author)
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Severi, Gianluca (author)
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Zeleniuch-Jacquotte, Anne (author)
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Lawrence, Charles (author)
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Burdette, Laurie (author)
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Yuenger, Jeffrey (author)
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Hutchinson, Amy (author)
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Jacobs, Kevin B. (author)
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Call, Timothy G. (author)
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Shanafelt, Tait D. (author)
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Novak, Anne J. (author)
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Kay, Neil E. (author)
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Liebow, Mark (author)
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Wang, Alice H. (author)
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- Smedby, Karin E. (author)
- Karolinska Institutet
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- Adami, Hans-Olov (author)
- Karolinska Institutet
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Melbye, Mads (author)
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Chang, Ellen T. (author)
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Glenn, Martha (author)
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Curtin, Karen (author)
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Cannon-Albright, Lisa A. (author)
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Jones, Brandt (author)
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Diver, W. Ryan (author)
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Link, Brian K. (author)
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Weiner, George J. (author)
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Conde, Lucia (author)
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Bracci, Paige M. (author)
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Riby, Jacques (author)
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Holly, Elizabeth A. (author)
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Smith, Martyn T. (author)
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Jackson, Rebecca D. (author)
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Tinker, Lesley F. (author)
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Benavente, Yolanda (author)
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Becker, Nikolaus (author)
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Boffetta, Paolo (author)
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Brennan, Paul (author)
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Foretova, Lenka (author)
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Maynadie, Marc (author)
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McKay, James (author)
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Staines, Anthony (author)
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Rabe, Kari G. (author)
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Achenbach, Sara J. (author)
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Vachon, Celine M. (author)
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Goldin, Lynn R. (author)
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Strom, Sara S. (author)
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Lanasa, Mark C. (author)
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Spector, Logan G. (author)
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Leis, Jose F. (author)
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Cunningham, Julie M. (author)
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Weinberg, J. Brice (author)
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Morrison, Vicki A. (author)
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Caporaso, Neil E. (author)
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Norman, Aaron D. (author)
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Linet, Martha S. (author)
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De Roos, Anneclaire J. (author)
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Morton, Lindsay M. (author)
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Severson, Richard K. (author)
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Riboli, Elio (author)
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Vineis, Paolo (author)
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Kaaks, Rudolph (author)
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Trichopoulos, Dimitrios (author)
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Masala, Giovanna (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Chirlaque, Mara-Dolores (author)
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Vermeulen, Roel C. H. (author)
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Travis, Ruth C. (author)
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Giles, Graham G. (author)
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Albanes, Demetrius (author)
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Virtamo, Jarmo (author)
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Weinstein, Stephanie (author)
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Clavel, Jacqueline (author)
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Zheng, Tongzhang (author)
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Holford, Theodore R. (author)
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Offit, Kenneth (author)
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Zelenetz, Andrew (author)
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Klein, Robert J. (author)
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Spinelli, John J. (author)
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Bertrand, Kimberly A. (author)
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Laden, Francine (author)
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Giovannucci, Edward (author)
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Kraft, Peter (author)
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Kricker, Anne (author)
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Turner, Jenny (author)
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Vajdic, Claire M. (author)
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Ennas, Maria Grazia (author)
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Ferri, Giovanni M. (author)
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Miligi, Lucia (author)
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Liang, Liming (author)
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Sampson, Joshua (author)
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Crouch, Simon (author)
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Park, Ju-Hyun (author)
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North, Kari E. (author)
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Cox, Angela (author)
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Snowden, John A. (author)
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Wright, Josh (author)
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Carracedo, Angel (author)
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Lopez-Otin, Carlos (author)
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Bea, Silvia (author)
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Salaverria, Itziar (author)
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Martin-Garcia, David (author)
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Campo, Elias (author)
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Fraumeni, Joseph F., Jr. (author)
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de Sanjose, Silvia (author)
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Hjalgrim, Henrik (author)
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Cerhan, James R. (author)
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Chanock, Stephen J. (author)
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Rothman, Nathaniel (author)
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Slager, Susan L. (author)
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(creator_code:org_t)
- 2013-06-16
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:8, s. 868-U202
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Berndt, Sonja I.
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Skibola, Christi ...
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Joseph, Vijai
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Camp, Nicola J.
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Nieters, Alexand ...
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Wang, Zhaoming
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show more...
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Cozen, Wendy
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Monnereau, Alain
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Wang, Sophia S.
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Kelly, Rachel S.
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Lan, Qing
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Teras, Lauren R.
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Chatterjee, Nila ...
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Chung, Charles C ...
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Yeager, Meredith
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Brooks-Wilson, A ...
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Hartge, Patricia
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Purdue, Mark P.
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Birmann, Brenda ...
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Armstrong, Bruce ...
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Cocco, Pierluigi
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Zhang, Yawei
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Severi, Gianluca
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Zeleniuch-Jacquo ...
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Lawrence, Charle ...
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Burdette, Laurie
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Yuenger, Jeffrey
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Hutchinson, Amy
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Jacobs, Kevin B.
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Call, Timothy G.
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Shanafelt, Tait ...
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Novak, Anne J.
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Kay, Neil E.
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Liebow, Mark
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Wang, Alice H.
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Smedby, Karin E.
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Adami, Hans-Olov
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Melbye, Mads
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Glimelius, Bengt
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Chang, Ellen T.
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Glenn, Martha
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Curtin, Karen
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Cannon-Albright, ...
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Jones, Brandt
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Diver, W. Ryan
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Link, Brian K.
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Weiner, George J ...
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Conde, Lucia
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Bracci, Paige M.
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Riby, Jacques
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Holly, Elizabeth ...
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Smith, Martyn T.
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Jackson, Rebecca ...
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Tinker, Lesley F ...
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Benavente, Yolan ...
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Becker, Nikolaus
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Boffetta, Paolo
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Brennan, Paul
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Foretova, Lenka
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Maynadie, Marc
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McKay, James
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Staines, Anthony
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Rabe, Kari G.
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Achenbach, Sara ...
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Vachon, Celine M ...
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Goldin, Lynn R.
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Strom, Sara S.
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Lanasa, Mark C.
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Spector, Logan G ...
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Leis, Jose F.
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Cunningham, Juli ...
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Weinberg, J. Bri ...
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Morrison, Vicki ...
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Caporaso, Neil E ...
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Norman, Aaron D.
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Linet, Martha S.
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De Roos, Annecla ...
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Morton, Lindsay ...
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Severson, Richar ...
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Riboli, Elio
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Vineis, Paolo
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Kaaks, Rudolph
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Trichopoulos, Di ...
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Masala, Giovanna
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Weiderpass, Elis ...
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Chirlaque, Mara- ...
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Vermeulen, Roel ...
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Travis, Ruth C.
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Giles, Graham G.
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Albanes, Demetri ...
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Virtamo, Jarmo
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Weinstein, Steph ...
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Clavel, Jacqueli ...
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Zheng, Tongzhang
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Holford, Theodor ...
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Offit, Kenneth
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Zelenetz, Andrew
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Klein, Robert J.
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Spinelli, John J ...
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Bertrand, Kimber ...
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Laden, Francine
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Giovannucci, Edw ...
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Kraft, Peter
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Kricker, Anne
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Turner, Jenny
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Vajdic, Claire M ...
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Ennas, Maria Gra ...
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Ferri, Giovanni ...
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Miligi, Lucia
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Liang, Liming
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Sampson, Joshua
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Crouch, Simon
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Park, Ju-Hyun
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North, Kari E.
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Cox, Angela
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Snowden, John A.
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Wright, Josh
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Carracedo, Angel
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Lopez-Otin, Carl ...
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Bea, Silvia
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Salaverria, Itzi ...
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Martin-Garcia, D ...
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Campo, Elias
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Fraumeni, Joseph ...
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de Sanjose, Silv ...
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Hjalgrim, Henrik
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Cerhan, James R.
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Chanock, Stephen ...
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Rothman, Nathani ...
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Slager, Susan L.
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show less...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Karolinska Institutet