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Sökning: (WFRF:(Mehran Roxana)) conttype:(refereed) > (2016) > Genetic risk, adher...

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FältnamnIndikatorerMetadata
00005311naa a2200469 4500
001oai:lup.lub.lu.se:325b6596-f603-40ba-919a-c4567101a4b4
003SwePub
008161228s2016 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/325b6596-f603-40ba-919a-c4567101a4b42 URI
0247 a https://doi.org/10.1056/NEJMoa16050862 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Khera, Amit V.u Helsinki University Central Hospital4 aut
2451 0a Genetic risk, adherence to a healthy lifestyle, and coronary disease
264 1c 2016
300 a 10 s.
520 a BACKGROUND Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. METHODS Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts - 7814 participants in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women's Genome Health Study (WGHS), and 22,389 in the Malmö Diet and Cancer Study (MDCS) - And in 4260 participants in the cross-sectional BioImage Study for whom genotype and covariate data were available. We also determined adherence to a healthy lifestyle among the participants using a scoring system consisting of four factors: no current smoking, no obesity, regular physical activity, and a healthy diet. RESULTS The relative risk of incident coronary events was 91% higher among participants at high genetic risk (top quintile of polygenic scores) than among those at low genetic risk (bottom quintile of polygenic scores) (hazard ratio, 1.91; 95% confidence interval [CI], 1.75 to 2.09). A favorable lifestyle (defined as at least three of the four healthy lifestyle factors) was associated with a substantially lower risk of coronary events than an unfavorable lifestyle (defined as no or only one healthy lifestyle factor), regardless of the genetic risk category. Among participants at high genetic risk, a favorable lifestyle was associated with a 46% lower relative risk of coronary events than an unfavorable lifestyle (hazard ratio, 0.54; 95% CI, 0.47 to 0.63). This finding corresponded to a reduction in the standardized 10-year incidence of coronary events from 10.7% for an unfavorable lifestyle to 5.1% for a favorable lifestyle in ARIC, from 4.6% to 2.0% in WGHS, and from 8.2% to 5.3% in MDCS. In the BioImage Study, a favorable lifestyle was associated with significantly less coronary-artery calcification within each genetic risk category. CONCLUSIONS Across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease. Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Emdin, Connor A.u Helsinki University Central Hospital4 aut
7001 a Drake, Isabelu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)med-ihm
7001 a Natarajan, Pradeepu Massachusetts General Hospital4 aut
7001 a Bick, Alexander G.u Helsinki University Central Hospital4 aut
7001 a Cook, Nancy R.u Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Chasman, Daniel I.u Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Baber, Usmanu Icahn School of Medicine at Mount Sinai4 aut
7001 a Mehran, Roxanau Icahn School of Medicine at Mount Sinai4 aut
7001 a Rader, Daniel J.u University of Pennsylvania4 aut
7001 a Fuster, Valentinu Icahn School of Medicine at Mount Sinai4 aut
7001 a Boerwinkle, Ericu Massachusetts General Hospital4 aut
7001 a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
7001 a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
7001 a Ridker, Paul M.u Brigham and Women's Hospital / Harvard Medical School4 aut
7001 a Kathiresan, Sekaru Helsinki University Central Hospital4 aut
7102 a Helsinki University Central Hospitalb Diabetes - kardiovaskulär sjukdom4 org
7730 t New England Journal of Medicineg 375:24, s. 2349-2358q 375:24<2349-2358x 0028-4793
8564 u http://dx.doi.org/10.1056/NEJMoa1605086y FULLTEXT
8564 8u https://lup.lub.lu.se/record/325b6596-f603-40ba-919a-c4567101a4b4
8564 8u https://doi.org/10.1056/NEJMoa1605086

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