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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005827naa a2200697 4500
001oai:lup.lub.lu.se:1a160021-4075-4daa-992e-0fd35b63ce4d
003SwePub
008160401s2002 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/1093982 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme
2451 0a Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group.
264 1c 2002
520 a Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221 malignant soft tissue tumors with clonal chromosome aberrations were subdivided according to general karyotypic features, such as degree of complexity and ploidy level, and rearrangements of specific chromosomal regions. The cytogenetic variables were analyzed regarding clinical outcome, using time to metastasis as the end point. Selected variables were then compared with established clinicopathological predictors of metastasis development. When the entire material was considered, 167 of 268 investigated cytogenetic variables were associated with clinical outcome. Focusing on the subset of 151 patients with high-grade sarcoma, 17 variables were identified that, besides grade and size, were associated with increased risk of metastasis development. A final Cox regression analysis identified five independent cytogenetic predictors of adverse outcome; breakpoints in chromosome regions 1p1, 1q4, 14q1, and 17q2, and gain of regions 6p1/p2. An increasing effect on metastatic risk was seen with increasing involvement of the selected cytogenetic variables, even when different histopathological types were studied separately. We conclude that cytogenetic data provide independent prognostic information in soft tissue sarcomas. Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Soft Tissue Neoplasms : secondary
653 a Prognosis
653 a Sarcoma : genetics
653 a Soft Tissue Neoplasms : pathology
653 a Sarcoma : secondary
653 a Soft Tissue Neoplasms : genetics
653 a Adolescence
653 a Sarcoma : pathology
653 a Adult
653 a Child
653 a Preschool
653 a Female
653 a Chromosome Aberrations
653 a Follow-Up Studies
653 a Human
653 a Infant
653 a Middle Age
653 a Newborn
653 a Male
7001 a Strömberg, Ulfu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-ust
7001 a Mandahl, Nilsu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-nma
7001 a Cin, Paola Dal4 aut
7001 a De Wever, Ivo4 aut
7001 a Fletcher, Christopher D M4 aut
7001 a Mitelman, Felixu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fmi
7001 a Rosai, Juan4 aut
7001 a Rydholm, Andersu Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ary
7001 a Sciot, Raf4 aut
7001 a Tallini, Giovanni4 aut
7001 a Van Den Berghe, Herman4 aut
7001 a Vanni, Roberta4 aut
7001 a Willén, Helena4 aut
7102 a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org
7730 t Cancer Researchg 62:14, s. 3980-3984q 62:14<3980-3984x 1538-7445
8564 u http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12124330&dopt=Abstractx freey FULLTEXT
8564 u http://cancerres.aacrjournals.org/cgi/content/full/62/14/3980x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/109398

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