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Quadrivalent vaccin...
Quadrivalent vaccine against human papillomavirus to prevent high-grade cervical lesions
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Villa, Luisa L. (author)
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Perez, Gonzalo (author)
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Kjaer, Susanne K. (author)
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show more...
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Paavonen, Jorma (author)
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Lehtinen, Matti (author)
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Munoz, Nubia (author)
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Sigurdsson, Kristjan (author)
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Hernandez-Avila, Mauricio (author)
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Skjeldestad, Finn Egil (author)
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Thoresen, Steinar (author)
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Garcia, Patricia (author)
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Majewski, Slawomir (author)
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- Dillner, Joakim (author)
- Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Olsson, Sven-Eric (author)
- Karolinska Institutet
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Tay, Eng Hseon (author)
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Bosch, F. Xavier (author)
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Ault, Kevin A. (author)
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Brown, Darron R. (author)
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Ferris, Daron G. (author)
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Koutsky, Laura A. (author)
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Kurman, Robert J. (author)
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Myers, Evan R. (author)
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Barr, Eliav (author)
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Boslego, John (author)
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Bryan, Janine (author)
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Esser, Mark T. (author)
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Gause, Christine K. (author)
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Hesley, Teresa M. (author)
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Lupinacci, Lisa C. (author)
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Sings, Heather L. (author)
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Taddeo, Frank J. (author)
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Thornton, Annemarie R. (author)
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Boulos, M. (author)
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Cox, J. T. (author)
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Langmark, F. (author)
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Modlin, J. (author)
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Munoz, A. (author)
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Odlind, V. (author)
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Wilkinson, E. (author)
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Ferenczy, A. (author)
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Kurman, R. (author)
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Ronett, B. (author)
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Stoler, M. (author)
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Andreoni, G. (author)
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Bahamondes, L. (author)
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Camargos, A. (author)
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Costa, R. (author)
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De Andrade, R. (author)
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Fedrizzi, E. (author)
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Ferriani, R. (author)
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Goncalves, M. (author)
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Laginha, F. (author)
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Mendonca, J. (author)
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Moreira, E., Jr. (author)
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Nonnenmacher, B. (author)
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Taborda, W. (author)
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Zanetta, D. (author)
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Ardila, J. (author)
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Balcazar, N. (author)
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Maldonado, I. (author)
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Revollo, F. (author)
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Ruiz, A. (author)
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Andersen, E. S. (author)
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Djursing, H. (author)
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Hansen, T. (author)
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Jorgensen, J. J. (author)
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Nilas, L. (author)
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Ottesen, B. (author)
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Petersen, L. K. (author)
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Thomsen, S. G. (author)
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Toftager-Larsen, K. (author)
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Apter, D. (author)
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Kekki, M. (author)
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Kuortti, M. (author)
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Lahti, L. (author)
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Lindroos, Y. (author)
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Lunnas, T. (author)
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Paavonen, J. (author)
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Palmroth, J. (author)
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Sigurdsson, K. (author)
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Lazcano, E. (author)
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Zertuche, J. (author)
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Dalaker, K. (author)
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Eriksen, B. (author)
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Erno, L. E. (author)
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Fiane, B. (author)
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Hesla, K. (author)
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Isachsen, M. Myhre (author)
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Iversen, O. E. (author)
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Kasin, K. (author)
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Kristoffersen, M. (author)
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Lunde, T. (author)
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Nordmark, P. T. (author)
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Nygaard, T. (author)
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Onsrud, M. (author)
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Riis-Johannessen, G. (author)
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Schiotz, H. (author)
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Skjeldestad, F. E. (author)
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Sundhagen, H. (author)
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Sviggum, O. (author)
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Trosterud, K. A. (author)
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Garcia, P. (author)
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Penny, M. (author)
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Vivar, A. (author)
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Basta, A. (author)
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Czajkowski, K. (author)
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Knapp, P. (author)
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Spaczynski, M. (author)
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Barnes, R. (author)
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Tay, E. H. (author)
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Elfgren, K. (author)
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Hardmeier, E. (author)
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Hellsten, C. (author)
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Hofte, C. (author)
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Jensen, P. (author)
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Johannisson, G. (author)
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Loewhagen, G. -B. (author)
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Olsson, S. -E. (author)
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Steinwall, M. (author)
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Tamsen, L. (author)
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Varnauskas, T. (author)
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- Wikstroem, A. (author)
- Karolinska Institutet
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Crawford, G. (author)
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Allen, B. (author)
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Ault, K. (author)
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Brown, D. (author)
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Edwards, R. (author)
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Comerci, J. (author)
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Giuliano, A. (author)
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Greer, S. (author)
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Hatch, K. (author)
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Kriesel, J. (author)
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Lalezari, J. (author)
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Partridge, E. (author)
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Sperling, R. (author)
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Spruance, S. (author)
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Stapleton, J. (author)
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Wright, P. (author)
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Zedler, P. (author)
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McCarroll, K. (author)
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Zhang, L. (author)
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Zhou, H. (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 356:19, s. 1915-1927
- Related links:
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http://dx.doi.org/10...
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show more...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
Close
- BACKGROUND: Human papillomavirus types 16 (HPV-16) and 18 (HPV-18) cause approximately 70% of cervical cancers worldwide. A phase 3 trial was conducted to evaluate a quadrivalent vaccine against HPV types 6, 11, 16, and 18 (HPV-6/11/16/18) for the prevention of high-grade cervical lesions associated with HPV-16 and HPV-18. METHODS: In this randomized, double-blind trial, we assigned 12,167 women between the ages of 15 and 26 years to receive three doses of either HPV-6/11/16/18 vaccine or placebo, administered at day 1, month 2, and month 6. The primary analysis was performed for a per-protocol susceptible population that included 5305 women in the vaccine group and 5260 in the placebo group who had no virologic evidence of infection with HPV-16 or HPV-18 through 1 month after the third dose (month 7). The primary composite end point was cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ, or cervical cancer related to HPV-16 or HPV-18. RESULTS: Subjects were followed for an average of 3 years after receiving the first dose of vaccine or placebo. Vaccine efficacy for the prevention of the primary composite end point was 98% (95.89% confidence interval [CI], 86 to 100) in the per-protocol susceptible population and 44% (95% CI, 26 to 58) in an intention-to-treat population of all women who had undergone randomization (those with or without previous infection). The estimated vaccine efficacy against all high-grade cervical lesions, regardless of causal HPV type, in this intention-to-treat population was 17% (95% CI, 1 to 31). CONCLUSIONS: In young women who had not been previously infected with HPV-16 or HPV-18, those in the vaccine group had a significantly lower occurrence of high-grade cervical intraepithelial neoplasia related to HPV-16 or HPV-18 than did those in the placebo group.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Villa, Luisa L.
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Perez, Gonzalo
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Kjaer, Susanne K ...
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Paavonen, Jorma
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Lehtinen, Matti
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Munoz, Nubia
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show more...
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Sigurdsson, Kris ...
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Hernandez-Avila, ...
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Skjeldestad, Fin ...
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Thoresen, Steina ...
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Garcia, Patricia
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Majewski, Slawom ...
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Dillner, Joakim
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Olsson, Sven-Eri ...
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Tay, Eng Hseon
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Bosch, F. Xavier
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Ault, Kevin A.
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Brown, Darron R.
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Ferris, Daron G.
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Koutsky, Laura A ...
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Kurman, Robert J ...
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Myers, Evan R.
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Barr, Eliav
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Boslego, John
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Bryan, Janine
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Esser, Mark T.
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Gause, Christine ...
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Hesley, Teresa M ...
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Lupinacci, Lisa ...
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Sings, Heather L ...
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Taddeo, Frank J.
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Thornton, Annema ...
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Boulos, M.
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Cox, J. T.
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Langmark, F.
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Modlin, J.
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Munoz, A.
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Odlind, V.
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Wilkinson, E.
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Ferenczy, A.
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Kurman, R.
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Ronett, B.
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Stoler, M.
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Andreoni, G.
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Bahamondes, L.
-
Camargos, A.
-
Costa, R.
-
De Andrade, R.
-
Fedrizzi, E.
-
Ferriani, R.
-
Goncalves, M.
-
Laginha, F.
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Mendonca, J.
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Moreira, E., Jr.
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Nonnenmacher, B.
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Taborda, W.
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Zanetta, D.
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Ardila, J.
-
Balcazar, N.
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Maldonado, I.
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Revollo, F.
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Ruiz, A.
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Andersen, E. S.
-
Djursing, H.
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Hansen, T.
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Jorgensen, J. J.
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Nilas, L.
-
Ottesen, B.
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Petersen, L. K.
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Thomsen, S. G.
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Toftager-Larsen, ...
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Apter, D.
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Kekki, M.
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Kuortti, M.
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Lahti, L.
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Lindroos, Y.
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Lunnas, T.
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Paavonen, J.
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Palmroth, J.
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Sigurdsson, K.
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Lazcano, E.
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Zertuche, J.
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Dalaker, K.
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Eriksen, B.
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Erno, L. E.
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Fiane, B.
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Hesla, K.
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Isachsen, M. Myh ...
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Iversen, O. E.
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Kasin, K.
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Kristoffersen, M ...
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Lunde, T.
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Nordmark, P. T.
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Nygaard, T.
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Onsrud, M.
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Riis-Johannessen ...
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Schiotz, H.
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Skjeldestad, F. ...
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Sundhagen, H.
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Sviggum, O.
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Trosterud, K. A.
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Garcia, P.
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Penny, M.
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Vivar, A.
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Basta, A.
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Czajkowski, K.
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Knapp, P.
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Spaczynski, M.
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Barnes, R.
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Tay, E. H.
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Elfgren, K.
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Hardmeier, E.
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Hellsten, C.
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Hofte, C.
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Jensen, P.
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Johannisson, G.
-
Loewhagen, G. -B ...
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Olsson, S. -E.
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Steinwall, M.
-
Tamsen, L.
-
Varnauskas, T.
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Wikstroem, A.
-
Crawford, G.
-
Allen, B.
-
Ault, K.
-
Brown, D.
-
Edwards, R.
-
Comerci, J.
-
Giuliano, A.
-
Greer, S.
-
Hatch, K.
-
Kriesel, J.
-
Lalezari, J.
-
Partridge, E.
-
Sperling, R.
-
Spruance, S.
-
Stapleton, J.
-
Wright, P.
-
Zedler, P.
-
McCarroll, K.
-
Zhang, L.
-
Zhou, H.
-
show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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New England Jour ...
- By the university
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Lund University
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Karolinska Institutet