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Atrial fibrillation...
Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
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Pulit, S. L. (author)
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Weng, L. C. (author)
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McArdle, P. F. (author)
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show more...
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Trinquart, L. (author)
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Choi, S. H. (author)
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Mitchell, B. D. (author)
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Rosand, J. (author)
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de Bakker, P. I. W. (author)
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Benjamin, E. J. (author)
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Ellinor, P. T. (author)
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Kittner, S. J. (author)
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Lubitz, S. A. (author)
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Anderson, C. D. (author)
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Christophersen, I. E. (author)
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Rienstra, M. (author)
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Roselli, C. (author)
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Yin, X. Y. (author)
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Geelhoed, B. (author)
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Barnard, J. (author)
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Lin, H. H. (author)
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Arking, D. E. (author)
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Smith, A. V. (author)
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Albert, C. M. (author)
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Chaffin, M. (author)
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Tucker, N. R. (author)
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Li, M. L. (author)
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Klarin, D. (author)
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Bihlmeyer, N. A. (author)
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Low, S. K. (author)
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Weeke, P. E. (author)
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Muller-Nurasyid, M. (author)
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Smith, J. G. (author)
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Brody, J. A. (author)
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Niemeijer, M. N. (author)
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Dorr, M. (author)
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Trompet, S. (author)
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Huffman, J. (author)
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Gustafsson, S. (author)
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Schurmann, C. (author)
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Kleber, M. E. (author)
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Lyytikainen, L. P. (author)
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Seppala, I. (author)
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Malik, R. (author)
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Horimoto, Arvr (author)
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Perez, M. (author)
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Sinisalo, J. (author)
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Aeschbacher, S. (author)
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Theriault, S. (author)
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Yao, J. (author)
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Radmanesh, F. (author)
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Weiss, S. (author)
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Teumer, A. (author)
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Clauss, S. (author)
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Deo, R. (author)
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Rader, D. J. (author)
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Shah, S. (author)
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Sun, A. (author)
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Hopewell, J. C. (author)
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Debette, S. (author)
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Chauhan, G. (author)
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Yang, Q. (author)
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Worrall, B. B. (author)
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Pare, G. (author)
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Kamatani, Y. (author)
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Hagemeijer, Y. P. (author)
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Verweij, N. (author)
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Siland, J. E. (author)
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Kubo, M. (author)
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Smith, J. D. (author)
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Van Wagoner, D. R. (author)
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Bis, J. C. (author)
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Perz, S. (author)
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Psaty, B. M. (author)
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Ridker, P. M. (author)
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Magnani, J. W. (author)
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Harris, T. B. (author)
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Launer, L. J. (author)
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Shoemaker, M. B. (author)
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Padmanabhan, S. (author)
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Haessler, J. (author)
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Bartz, T. M. (author)
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Waldenberger, M. (author)
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Lichtner, P. (author)
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Arendt, M. (author)
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Krieger, J. E. (author)
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Kahonen, M. (author)
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Risch, L. (author)
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Mansur, A. J. (author)
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Smith, B. H. (author)
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Lind, L. (author)
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Scott, S. A. (author)
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Lu, Y. C. (author)
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Bottinger, E. B. (author)
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Hernesniemi, J. (author)
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Lindgren, C. M. (author)
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Wong, J. A. (author)
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Huang, J. (author)
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Eskola, M. (author)
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Morris, A. P. (author)
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Ford, I. (author)
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Reiner, A. P. (author)
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Delgado, G. (author)
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Chen, L. Y. (author)
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Chen, Y. D. I. (author)
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Sandhu, R. K. (author)
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Li, M. (author)
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Boerwinkle, E. (author)
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Eisele, L. (author)
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Lannfelt, L. (author)
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Rost, N. (author)
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Taylor, K. D. (author)
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Campbell, A. (author)
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Magnusson, P. K. (author)
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Porteous, D. (author)
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Hocking, L. J. (author)
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Vlachopoulou, E. (author)
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Pedersen, N. L. (author)
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Nikus, K. (author)
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Orho-Melander, M. (author)
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Hamsten, A. (author)
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Heeringa, J. (author)
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Denny, J. C. (author)
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Kriebel, J. (author)
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Darbar, D. (author)
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Newton-Cheh, C. (author)
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Shaffer, C. (author)
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Macfarlane, P. W. (author)
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Heilmann, S. (author)
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Almgren, P. (author)
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Huang, P. L. (author)
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Sotoodehnia, N. (author)
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Soliman, E. Z. (author)
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Uitterlinden, A. G. (author)
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Hofman, A. (author)
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Franco, O. H. (author)
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Volker, U. (author)
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Jockel, K. H. (author)
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Sinner, M. F. (author)
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Lin, H. J. (author)
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Guo, X. Q. (author)
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Dichgans, M. (author)
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Ingelsson, E. (author)
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Kooperberg, C. (author)
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Melander, O. (author)
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Loos, R. J. F. (author)
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Laurikka, J. (author)
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Conen, D. (author)
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van der Harst, P. (author)
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Lokki, M. L. (author)
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Kathiresan, S. (author)
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Pereira, A. (author)
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Jukema, J. W. (author)
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Hayward, C. (author)
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Rotter, J. I. (author)
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Marz, W. (author)
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Lehtimaki, T. (author)
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Stricker, B. H. (author)
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Chung, M. K. (author)
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Felix, S. B. (author)
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Gudnason, V. (author)
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Heckbert, S. R. (author)
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Tanaka, T. (author)
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Lunetta, K. L. (author)
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Smoller, S. (author)
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Sorkin, J. (author)
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Wang, X. W. (author)
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Selim, M. (author)
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Pikula, A. (author)
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Wolf, P. (author)
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Seshadri, S. (author)
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de Bakker, P. (author)
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Chasman, D. (author)
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Rexrode, K. (author)
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Chen, I. (author)
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Rotter, J. (author)
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Luke, M. (author)
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Sale, M. (author)
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Lee, T. H. (author)
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Chang, K. C. (author)
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Elkind, M. (author)
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Goldstein, L. (author)
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James, M. L. (author)
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Breteler, M. (author)
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O'Donnell, C. (author)
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Leys, D. (author)
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Carty, C. (author)
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Kidwell, C. (author)
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Olesen, J. (author)
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Sharma, P. (author)
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Rich, S. (author)
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Tatlisumak, T. (author)
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Happola, O. (author)
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Bijlenga, P. (author)
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Soriano, C. (author)
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Giralt, E. (author)
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Roquer, J. (author)
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Jimenez-Conde, J. (author)
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Cotlarcius, I. (author)
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Hardy, J. (author)
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Korostynski, M. (author)
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Boncoraglio, G. (author)
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Ballabio, E. (author)
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Parati, E. (author)
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Mateusz, A. (author)
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Urbanik, A. (author)
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Dziedzic, T. (author)
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Jagiella, J. (author)
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Gasowski, J. (author)
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Wnuk, M. (author)
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Olszanecki, R. (author)
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Pera, J. (author)
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Slowik, A. (author)
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Juchniewicz, K. J. (author)
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Levi, C. (author)
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Nyquist, P. (author)
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Cendes, I. (author)
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Cabral, N. (author)
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Franca, P. (author)
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Goncalves, A. (author)
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Keller, L. (author)
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Crisby, M. (author)
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Kostulas, K. (author)
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Lemmens, R. (author)
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Ahmadi, K. (author)
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Opherk, C. (author)
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Duering, M. (author)
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Gonik, M. (author)
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Staals, J. (author)
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Burri, P. (author)
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Sadr-Nabavi, A. (author)
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Romero, J. (author)
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Biffi, A. (author)
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Anderson, C. (author)
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Falcone, G. (author)
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Brouwers, B. (author)
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Du, R. (author)
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Kourkoulis, C. (author)
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Battey, T. (author)
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Lubitz, S. (author)
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Mueller-Myhsok, B. (author)
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Meschia, J. (author)
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Brott, T. (author)
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Pichler, A. (author)
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Enzinger, C. (author)
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Schmidt, H. (author)
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Schmidt, R. (author)
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Seiler, S. (author)
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Blanton, S. (author)
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Yamada, Y. (author)
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Bersano, A. (author)
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Rundek, T. (author)
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Sacco, R. (author)
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Chan, Y. F. Y. (author)
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Gschwendtner, A. (author)
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Launer, L. (author)
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Le, K. E. (author)
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Lee, W. L. (author)
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Tan, E. K. (author)
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Olugbodi, A. (author)
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Rothwell, P. (author)
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Mok, V. (author)
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Lebedeva, E. (author)
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Jern, C. (author)
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Olsson, S. (author)
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Kilarski, L. (author)
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Sheu, W. (author)
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Chern, J. (author)
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Giraldo, E. (author)
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Taqi, M. (author)
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Jain, V. (author)
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Lam, O. (author)
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Howard, G. (author)
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Woo, D. (author)
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Kittner, S. (author)
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Mitchell, B. (author)
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Cole, J. (author)
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O'Connell, J. (author)
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Milewicz, D. (author)
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Worrall, B. (author)
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Karaszewski, B. (author)
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Werring, D. (author)
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Smalley, J. (author)
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Silliman, S. (author)
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McDonough, C. (author)
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Walters, M. (author)
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- Pedersen, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine
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Nakagawa, K. (author)
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Chang, C. (author)
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Dobbins, M. (author)
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McArdle, P. (author)
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Chang, Y. C. (author)
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Brown, R. (author)
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Brown, D. (author)
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Holliday, E. (author)
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Kalaria, R. (author)
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Maguire, J. (author)
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Attia, J. (author)
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Farrall, M. (author)
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Giese, A. K. (author)
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Fornage, M. (author)
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Majersik, J. (author)
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Cushman, M. (author)
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Keene, K. (author)
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Bennett, S. (author)
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Tirschwell, D. (author)
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Psaty, B. (author)
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Reiner, A. (author)
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Longstreth, W. (author)
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Spence, D. (author)
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Montaner, J. (author)
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Fernandez-Cadenas, I. (author)
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Langefeld, C. (author)
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Bushnell, C. (author)
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Heitsch, L. (author)
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Lee, J. M. (author)
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Sheth, K. (author)
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Atrial Fibrillation Genetics Conso; Int Stroke Genetics, Consortium (author)
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(creator_code:org_t)
- 2018-12-03
- 2018
- English.
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In: Neurology-Genetics. - : Ovid Technologies (Wolters Kluwer Health). - 2376-7839. ; 4:6
- Related links:
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https://ng.neurology...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p < 4.4 x 10(-4) in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio [OR] per SD = 1.40, p = 1.45 x 10(-48)), explaining similar to 20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07,p = 0.004), but no other primary stroke subtypes (all p > 0.1). Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- ischemic-stroke
- causative classification
- lifetime risk
- epidemiology
- association
- prevention
- variants
- aspirin
- burden
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pulit, S. L.
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Weng, L. C.
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McArdle, P. F.
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Trinquart, L.
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Choi, S. H.
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Mitchell, B. D.
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show more...
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Rosand, J.
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de Bakker, P. I. ...
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Benjamin, E. J.
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Ellinor, P. T.
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Kittner, S. J.
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Lubitz, S. A.
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Anderson, C. D.
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Christophersen, ...
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Rienstra, M.
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Roselli, C.
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Yin, X. Y.
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Geelhoed, B.
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Barnard, J.
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Lin, H. H.
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Arking, D. E.
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Smith, A. V.
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Albert, C. M.
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Chaffin, M.
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Tucker, N. R.
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Li, M. L.
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Klarin, D.
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Bihlmeyer, N. A.
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Low, S. K.
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Weeke, P. E.
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Muller-Nurasyid, ...
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Smith, J. G.
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Brody, J. A.
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Niemeijer, M. N.
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Dorr, M.
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Trompet, S.
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Huffman, J.
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Gustafsson, S.
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Schurmann, C.
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Kleber, M. E.
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Lyytikainen, L. ...
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Seppala, I.
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Malik, R.
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Horimoto, Arvr
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Perez, M.
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Sinisalo, J.
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Aeschbacher, S.
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Theriault, S.
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Yao, J.
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Radmanesh, F.
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Weiss, S.
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Teumer, A.
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Clauss, S.
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Deo, R.
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Rader, D. J.
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Shah, S.
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Sun, A.
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Hopewell, J. C.
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Debette, S.
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Chauhan, G.
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Yang, Q.
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Worrall, B. B.
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Pare, G.
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Kamatani, Y.
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Hagemeijer, Y. P ...
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Verweij, N.
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Siland, J. E.
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Kubo, M.
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Smith, J. D.
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Van Wagoner, D. ...
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Bis, J. C.
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Perz, S.
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Psaty, B. M.
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Ridker, P. M.
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Magnani, J. W.
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Harris, T. B.
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Launer, L. J.
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Shoemaker, M. B.
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Padmanabhan, S.
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Haessler, J.
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Bartz, T. M.
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Waldenberger, M.
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Lichtner, P.
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Arendt, M.
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Krieger, J. E.
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Kahonen, M.
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Risch, L.
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Mansur, A. J.
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Peters, A.
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Smith, B. H.
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Lind, L.
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Scott, S. A.
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Lu, Y. C.
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Bottinger, E. B.
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Hernesniemi, J.
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Lindgren, C. M.
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Wong, J. A.
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Huang, J.
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Eskola, M.
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Morris, A. P.
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Ford, I.
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Reiner, A. P.
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Delgado, G.
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Chen, L. Y.
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Chen, Y. D. I.
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Sandhu, R. K.
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Li, M.
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Boerwinkle, E.
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Eisele, L.
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Lannfelt, L.
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Rost, N.
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Taylor, K. D.
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Campbell, A.
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Magnusson, P. K.
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Porteous, D.
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Hocking, L. J.
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Vlachopoulou, E.
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Pedersen, N. L.
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Nikus, K.
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Orho-Melander, M ...
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Hamsten, A.
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Heeringa, J.
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Denny, J. C.
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Kriebel, J.
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Darbar, D.
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Newton-Cheh, C.
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Shaffer, C.
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Macfarlane, P. W ...
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Heilmann, S.
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Almgren, P.
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Huang, P. L.
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Sotoodehnia, N.
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Soliman, E. Z.
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Uitterlinden, A. ...
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Hofman, A.
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Franco, O. H.
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Volker, U.
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Jockel, K. H.
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Sinner, M. F.
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Lin, H. J.
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Guo, X. Q.
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Dichgans, M.
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Ingelsson, E.
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Kooperberg, C.
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Melander, O.
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Loos, R. J. F.
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Laurikka, J.
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Conen, D.
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van der Harst, P ...
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Lokki, M. L.
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Kathiresan, S.
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Pereira, A.
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Jukema, J. W.
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Hayward, C.
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Rotter, J. I.
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Marz, W.
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Lehtimaki, T.
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Stricker, B. H.
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Chung, M. K.
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Felix, S. B.
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Gudnason, V.
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Alonso, A.
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Roden, D. M.
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Kaab, S.
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Chasman, D. I.
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Heckbert, S. R.
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Tanaka, T.
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Lunetta, K. L.
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Smoller, S.
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Sorkin, J.
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Wang, X. W.
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Selim, M.
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Pikula, A.
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Wolf, P.
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Seshadri, S.
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de Bakker, P.
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Chasman, D.
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Rexrode, K.
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Chen, I.
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Rotter, J.
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Luke, M.
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Sale, M.
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Lee, T. H.
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Chang, K. C.
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Elkind, M.
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Goldstein, L.
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James, M. L.
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Breteler, M.
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O'Donnell, C.
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Leys, D.
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Carty, C.
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Kidwell, C.
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Olesen, J.
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Sharma, P.
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Rich, S.
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Tatlisumak, T.
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Happola, O.
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Bijlenga, P.
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Soriano, C.
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Giralt, E.
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Roquer, J.
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Jimenez-Conde, J ...
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Cotlarcius, I.
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