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Illness severity an...
Illness severity and risk of mental morbidities among patients recovering from COVID-19: a cross-sectional study in the Icelandic population
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Saevarsdottir, KS (author)
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Hilmarsdottir, HY (author)
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Magnusdottir, I (author)
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Hauksdottir, A (author)
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Thordardottir, EB (author)
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Gudjonsdottir, AB (author)
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Tomasson, G (author)
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Runarsdottir, H (author)
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Jonsdottir, HL (author)
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Gudmundsdottir, B (author)
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Petursdottir, G (author)
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Petersen, PH (author)
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Kristinsson, SY (author)
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Love, TJ (author)
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Hansdottir, S (author)
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Hardardottir, H (author)
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Gudmundsson, G (author)
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Eythorsson, E (author)
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Gudmundsdottir, DG (author)
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Sigbjornsdottir, H (author)
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Haraldsdottir, S (author)
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Moller, AD (author)
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Palsson, R (author)
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Jakobsdottir, J (author)
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Aspelund, T (author)
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- Valdimarsdottir, U (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-07-23
- 2021
- English.
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:7, s. e049967-
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https://bmjopen.bmj....
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- To test if patients recovering from COVID-19 are at increased risk of mental morbidities and to what extent such risk is exacerbated by illness severity.DesignPopulation-based cross-sectional study.SettingIceland.ParticipantsA total of 22 861 individuals were recruited through invitations to existing nationwide cohorts and a social media campaign from 24 April to 22 July 2020, of which 373 were patients recovering from COVID-19.Main outcome measuresSymptoms of depression (Patient Health Questionnaire), anxiety (General Anxiety Disorder Scale) and posttraumatic stress disorder (PTSD; modified Primary Care PTSD Screen for DSM-5) above screening thresholds. Adjusting for multiple covariates and comorbidities, multivariable Poisson regression was used to assess the association between COVID-19 severity and mental morbidities.ResultsCompared with individuals without a diagnosis of COVID-19, patients recovering from COVID-19 had increased risk of depression (22.1% vs 16.2%; adjusted relative risk (aRR) 1.48, 95% CI 1.20 to 1.82) and PTSD (19.5% vs 15.6%; aRR 1.38, 95% CI 1.09 to 1.75) but not anxiety (13.1% vs 11.3%; aRR 1.24, 95% CI 0.93 to 1.64). Elevated relative risks were limited to patients recovering from COVID-19 that were 40 years or older and were particularly high among individuals with university education. Among patients recovering from COVID-19, symptoms of depression were particularly common among those in the highest, compared with the lowest tertile of influenza-like symptom burden (47.1% vs 5.8%; aRR 6.42, 95% CI 2.77 to 14.87), among patients confined to bed for 7 days or longer compared with those never confined to bed (33.3% vs 10.9%; aRR 3.67, 95% CI 1.97 to 6.86) and among patients hospitalised for COVID-19 compared with those never admitted to hospital (48.1% vs 19.9%; aRR 2.72, 95% CI 1.67 to 4.44).ConclusionsSevere disease course is associated with increased risk of depression and PTSD among patients recovering from COVID-19.
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BMJ open
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Saevarsdottir, K ...
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Hilmarsdottir, H ...
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Magnusdottir, I
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Hauksdottir, A
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Thordardottir, E ...
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Gudjonsdottir, A ...
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show more...
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Tomasson, G
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Runarsdottir, H
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Jonsdottir, HL
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Gudmundsdottir, ...
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Petursdottir, G
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Petersen, PH
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Kristinsson, SY
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Love, TJ
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Hansdottir, S
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Hardardottir, H
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Gudmundsson, G
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Eythorsson, E
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Gudmundsdottir, ...
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Sigbjornsdottir, ...
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Haraldsdottir, S
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Moller, AD
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Palsson, R
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Jakobsdottir, J
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Aspelund, T
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Valdimarsdottir, ...
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show less...
- Articles in the publication
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BMJ open
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Karolinska Institutet