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Individual common v...
Individual common variants exert weak effects on the risk for autism spectrum disorders.
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Anney, Richard (author)
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Klei, Lambertus (author)
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Pinto, Dalila (author)
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show more...
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Almeida, Joana (author)
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Bacchelli, Elena (author)
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Baird, Gillian (author)
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Bolshakova, Nadia (author)
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Bölte, Sven (author)
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Bolton, Patrick F. (author)
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Bourgeron, Thomas (author)
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Brennan, Sean (author)
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Brian, Jessica (author)
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Casey, Jillian (author)
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Conroy, Judith (author)
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Correia, Catarina (author)
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Corsello, Christina (author)
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Crawford, Emily L (author)
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de Jonge, Maretha (author)
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Delorme, Richard (author)
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Duketis, Eftichia (author)
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Duque, Frederico (author)
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Estes, Annette (author)
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Farrar, Penny (author)
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Fernandez, Bridget A (author)
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Folstein, Susan E (author)
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Fombonne, Eric (author)
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Gilbert, John (author)
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- Gillberg, Christopher, 1950 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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Glessner, Joseph T (author)
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Green, Andrew (author)
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Green, Jonathan (author)
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Guter, Stephen J (author)
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Heron, Elizabeth A (author)
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Holt, Richard (author)
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Howe, Jennifer L (author)
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Hughes, Gillian (author)
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Hus, Vanessa (author)
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Igliozzi, Roberta (author)
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Jacob, Suma (author)
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Kenny, Graham P (author)
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Kim, Cecilia (author)
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Kolevzon, Alexander (author)
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Kustanovich, Vlad (author)
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Lajonchere, Clara M (author)
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Lamb, Janine A (author)
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Law-Smith, Miriam (author)
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Leboyer, Marion (author)
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Le Couteur, Ann (author)
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Leventhal, Bennett L (author)
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Liu, Xiao-Qing (author)
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Lombard, Frances (author)
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Lord, Catherine (author)
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Lotspeich, Linda (author)
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Lund, Sabata C (author)
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Magalhaes, Tiago R (author)
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Mantoulan, Carine (author)
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McDougle, Christopher J (author)
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Melhem, Nadine M (author)
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Merikangas, Alison (author)
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Minshew, Nancy J (author)
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Mirza, Ghazala K (author)
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Munson, Jeff (author)
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Noakes, Carolyn (author)
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- Nygren, Gudrun, 1957 (author)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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Papanikolaou, Katerina (author)
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Pagnamenta, Alistair T (author)
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Parrini, Barbara (author)
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Paton, Tara (author)
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Pickles, Andrew (author)
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Posey, David J (author)
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Poustka, Fritz (author)
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Ragoussis, Jiannis (author)
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Regan, Regina (author)
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Renshaw, Katy (author)
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Roberts, Wendy (author)
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Roeder, Kathryn (author)
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Roge, Bernadette (author)
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Rutter, Michael L (author)
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Schlitt, Sabine (author)
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Shah, Naisha (author)
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Sheffield, Val C (author)
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Soorya, Latha (author)
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Sousa, Inês (author)
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Stoppioni, Vera (author)
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Sykes, Nuala (author)
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Tancredi, Raffaella (author)
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Thompson, Ann P (author)
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Thomson, Susanne (author)
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Tryfon, Ana (author)
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Tsiantis, John (author)
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Van Engeland, Herman (author)
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Vincent, John B (author)
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Vorstman, Jas (author)
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Volkmar, Fred (author)
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Wallace, Simon (author)
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Wing, Kirsty (author)
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Wood, Shawn (author)
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Wittemeyer, Kerstin (author)
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Zurawiecki, Danielle (author)
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Zwaigenbaum, Lonnie (author)
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Bailey, Anthony J (author)
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Battaglia, Agatino (author)
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Cantor, Rita M (author)
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Coon, Hilary (author)
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Cuccaro, Michael L (author)
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Dawson, Geraldine (author)
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Ennis, Sean (author)
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Freitag, Christine M (author)
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Geschwind, Daniel H (author)
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Haines, Jonathan L (author)
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Klauck, Sabine M (author)
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McMahon, William M (author)
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Maestrini, Elena (author)
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Miller, Judith (author)
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Monaco, Anthony P (author)
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Nelson, Stanley F (author)
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Nurnberger, John I (author)
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Oliveira, Guiomar (author)
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Parr, Jeremy R (author)
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Pericak-Vance, Margaret A (author)
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Piven, Joseph (author)
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Schellenberg, Gerard D (author)
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Scherer, Stephen W (author)
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Vicente, Astrid M (author)
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Wassink, Thomas H (author)
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Wijsman, Ellen M (author)
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Betancur, Catalina (author)
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Buxbaum, Joseph D (author)
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Cook, Edwin H (author)
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Gallagher, Louise (author)
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Gill, Michael (author)
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Hallmayer, Joachim (author)
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Paterson, Andrew D (author)
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Sutcliffe, James S (author)
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Szatmari, Peter (author)
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Vieland, Veronica J (author)
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Hakonarson, Hakon (author)
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Devlin, Bernie (author)
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(creator_code:org_t)
- 2012-07-26
- 2012
- English.
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:21, s. 4781-92
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASD), the contribution of common variation to ASD risk is less clear. To produce a more comprehensive picture, we report Stage 2 of the Autism Genome Project genome-wide association study, adding 1301 ASD families and bringing the total to 2705 families analysed (Stages 1 and 2). In addition to evaluating association of individual SNPs, we also sought evidence that common variants, en masse, might affect risk. Despite genotyping over a million SNPs covering the genome, no single SNP shows significant association with ASD or selected phenotypes at a genome-wide level. The SNP that achieves the smallest p-value from secondary analyses is rs1718101. It falls in CNTNAP2, a gene previously implicated in susceptibility for ASD. This SNP also shows modest association with age of word/phrase acquisition in ASD subjects, of interest because features of language development are also associated with other variation in CNTNAP2. By contrast, allele-scores derived from the transmission of common alleles to Stage 1 cases significantly predict case-status in the independent Stage 2 sample. Despite being significant, the variance explained by these allele scores was small (Vm< 1%). Based on results from individual SNPs and their en masse effect on risk, as inferred from the allele-score results, it is reasonable to conclude that common variants affect ASD risk but their individual effects are modest.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Anney, Richard
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Klei, Lambertus
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Pinto, Dalila
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Almeida, Joana
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Bacchelli, Elena
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Baird, Gillian
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show more...
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Bolshakova, Nadi ...
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Bölte, Sven
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Bolton, Patrick ...
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Bourgeron, Thoma ...
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Brennan, Sean
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Brian, Jessica
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Casey, Jillian
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Conroy, Judith
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Correia, Catarin ...
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Corsello, Christ ...
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Crawford, Emily ...
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de Jonge, Mareth ...
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Delorme, Richard
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Duketis, Eftichi ...
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Duque, Frederico
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Estes, Annette
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Farrar, Penny
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Fernandez, Bridg ...
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Folstein, Susan ...
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Fombonne, Eric
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Gilbert, John
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Gillberg, Christ ...
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Glessner, Joseph ...
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Green, Andrew
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Green, Jonathan
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Guter, Stephen J
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Heron, Elizabeth ...
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Holt, Richard
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Howe, Jennifer L
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Hughes, Gillian
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Hus, Vanessa
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Igliozzi, Robert ...
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Jacob, Suma
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Kenny, Graham P
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Kim, Cecilia
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Kolevzon, Alexan ...
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Kustanovich, Vla ...
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Lajonchere, Clar ...
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Lamb, Janine A
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Law-Smith, Miria ...
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Leboyer, Marion
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Le Couteur, Ann
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Leventhal, Benne ...
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Liu, Xiao-Qing
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Lombard, Frances
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Lord, Catherine
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Lotspeich, Linda
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Lund, Sabata C
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Magalhaes, Tiago ...
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Mantoulan, Carin ...
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McDougle, Christ ...
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Melhem, Nadine M
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Merikangas, Alis ...
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Minshew, Nancy J
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Mirza, Ghazala K
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Munson, Jeff
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Noakes, Carolyn
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Nygren, Gudrun, ...
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Papanikolaou, Ka ...
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Pagnamenta, Alis ...
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Parrini, Barbara
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Paton, Tara
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Pickles, Andrew
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Posey, David J
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Poustka, Fritz
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Ragoussis, Jiann ...
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Regan, Regina
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Renshaw, Katy
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Roberts, Wendy
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Roeder, Kathryn
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Roge, Bernadette
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Rutter, Michael ...
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Schlitt, Sabine
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Shah, Naisha
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Sheffield, Val C
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Soorya, Latha
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Sousa, Inês
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Stoppioni, Vera
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Sykes, Nuala
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Tancredi, Raffae ...
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Thompson, Ann P
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Thomson, Susanne
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Tryfon, Ana
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Tsiantis, John
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Van Engeland, He ...
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Vincent, John B
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Vorstman, Jas
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Volkmar, Fred
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Wallace, Simon
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Wing, Kirsty
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Wood, Shawn
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Wittemeyer, Kers ...
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Zurawiecki, Dani ...
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Zwaigenbaum, Lon ...
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Bailey, Anthony ...
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Battaglia, Agati ...
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Cantor, Rita M
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Coon, Hilary
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Cuccaro, Michael ...
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Dawson, Geraldin ...
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Ennis, Sean
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Freitag, Christi ...
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Geschwind, Danie ...
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Haines, Jonathan ...
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Klauck, Sabine M
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McMahon, William ...
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Maestrini, Elena
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Miller, Judith
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Monaco, Anthony ...
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Nelson, Stanley ...
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Nurnberger, John ...
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Oliveira, Guioma ...
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Parr, Jeremy R
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Pericak-Vance, M ...
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Piven, Joseph
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Schellenberg, Ge ...
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Scherer, Stephen ...
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Vicente, Astrid ...
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Wassink, Thomas ...
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Wijsman, Ellen M
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Betancur, Catali ...
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Buxbaum, Joseph ...
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Cook, Edwin H
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Gallagher, Louis ...
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Gill, Michael
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Hallmayer, Joach ...
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Paterson, Andrew ...
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Sutcliffe, James ...
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Szatmari, Peter
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Vieland, Veronic ...
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Hakonarson, Hako ...
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Devlin, Bernie
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Human Molecular ...
- By the university
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University of Gothenburg