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Antibody Responses ...
Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer
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Butt, Julia (author)
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Jenab, Mazda (author)
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Pawlita, Michael (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Boutron-Ruault, Marie-Christine (author)
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Carbonnel, Franck (author)
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Mancini, Francesca Romana (author)
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Kaaks, Rudolf (author)
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Kühn, Tilman (author)
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Boeing, Heiner (author)
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Trichopoulou, Antonia (author)
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Karakatsani, Anna (author)
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Palli, Domenico (author)
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Pala, Valeria Maria (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, Bas (author)
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van Gils, Carla H. (author)
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Vermeulen, Roel C. H. (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Quiros, Jose Ramon (author)
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Duell, Eric Jeffrey (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Maria Huerta, Jose (author)
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Ardanaz, Eva (author)
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- van Guelpen, Bethany (author)
- Umeå universitet,Onkologi
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- Harlid, Sophia, 1978- (author)
- Umeå universitet,Onkologi
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Perez-Cornago, Aurora (author)
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Gunter, Marc J. (author)
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Murphy, Neil (author)
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Freisling, Heinz (author)
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Aune, Dagfinn (author)
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Waterboer, Tim (author)
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Hughes, David J. (author)
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(creator_code:org_t)
- American Association for Cancer Research, 2019
- 2019
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 28:9, s. 1552-1555
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: There is a lack of prospective data on the potential association of Fusobacterium nucleatum (F. nucleatum) and colorectal cancer risk. In this study, we assessed whether antibody responses to F. nucleatum are associated with colorectal cancer risk in prediagnostic serum samples in the European Prospective Investigation into Nutrition and Cancer (EPIC) cohort.Methods: We applied a multiplex serology assay to simultaneously measure antibody responses to 11 F. nucleatum antigens in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI).Results: We observed neither a statistically significant colorectal cancer risk association for antibodies to individual F. nucleatum proteins nor for combined positivity to any of the 11 proteins (OR, 0.81; 95% CI, 0.62–1.06).Conclusions: Antibody responses to F. nucleatum proteins in prediagnostic serum samples from a subset of colorectal cancer cases and matched controls within the EPIC study were not associated with colorectal cancer risk.Impact: Our findings in prospectively ascertained serum samples contradict the existing literature on the association of F. nucleatum with colorectal cancer risk. Future prospective studies, specifically detecting F. nucleatum in stool or tissue biopsies, are needed to complement our findings.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Butt, Julia
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Jenab, Mazda
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Pawlita, Michael
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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show more...
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Boutron-Ruault, ...
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Carbonnel, Franc ...
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Mancini, Frances ...
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Kaaks, Rudolf
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Kühn, Tilman
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Boeing, Heiner
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Trichopoulou, An ...
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Karakatsani, Ann ...
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Palli, Domenico
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Pala, Valeria Ma ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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van Gils, Carla ...
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Vermeulen, Roel ...
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Weiderpass, Elis ...
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Quiros, Jose Ram ...
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Duell, Eric Jeff ...
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Maria Huerta, Jo ...
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Ardanaz, Eva
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van Guelpen, Bet ...
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Harlid, Sophia, ...
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Perez-Cornago, A ...
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Gunter, Marc J.
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Murphy, Neil
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Freisling, Heinz
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Aune, Dagfinn
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Waterboer, Tim
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Hughes, David J.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Karolinska Institutet