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The onset of circul...
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition
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- Azzoni, Emanuele (author)
- University of Oxford
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- Frontera, Vincent (author)
- University of Oxford
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- Anselmi, Giorgio (author)
- University of Oxford
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- Rode, Christina (author)
- University of Oxford
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- James, Chela (author)
- UCL Cancer Institute
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- Deltcheva, Elitza M. (author)
- UCL Cancer Institute
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- Demian, Atanasiu S. (author)
- University of Oxford
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- Brown, John (author)
- UCL Cancer Institute
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- Barone, Cristiana (author)
- University of Milano-Bicocca
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- Patelli, Arianna (author)
- University of Milano-Bicocca
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- Harman, Joe R. (author)
- University of Oxford
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- Nicholls, Matthew (author)
- University of Oxford
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- Conway, Simon J. (author)
- Indiana University
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- Morrissey, Edward (author)
- University of Oxford
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- Jacobsen, Sten Eirik W. (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,University of Oxford
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- Sparrow, Duncan B. (author)
- University of Oxford
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- Harris, Adrian L. (author)
- University of Oxford
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- Enver, Tariq (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,UCL Cancer Institute
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- de Bruijn, Marella F.T.R. (author)
- University of Oxford
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 37:11
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Abstract
Subject headings
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- Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1−/− mouse embryos devoid of circulation the HSC lineage develops until the phenotypic pro-HSC stage. However, these cells reside in an abnormal microenvironment, fail to activate the hematopoietic program downstream of Runx1, and are functionally impaired. Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1−/− cells fail to undergo a glycolysis to oxidative phosphorylation metabolic switch present in wild-type cells. Interestingly, experimental activation of glycolysis results in decreased intraembryonic hematopoiesis. Our results suggest that the onset of circulation triggers metabolic changes that allow HSC generation to proceed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Azzoni, Emanuele
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Frontera, Vincen ...
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Anselmi, Giorgio
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Rode, Christina
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James, Chela
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Deltcheva, Elitz ...
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show more...
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Demian, Atanasiu ...
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Brown, John
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Barone, Cristian ...
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Patelli, Arianna
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Harman, Joe R.
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Nicholls, Matthe ...
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Conway, Simon J.
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Morrissey, Edwar ...
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Jacobsen, Sten E ...
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Sparrow, Duncan ...
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Harris, Adrian L ...
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Enver, Tariq
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de Bruijn, Marel ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Lund University
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Karolinska Institutet